DegronMD

Uniprot ID: Q9Y6N7

Source protein: Roundabout homolog 1

Source gene: ROBO1

Class: DEG_SCF_FBW7_1

Location: 1070:1075

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 53.05

COIL: 0.6767

CONS_SCORE: 0.3871

DSS_SCORE: 0.626

HELIX: 0.0472

FCONS_SCORE: 1.264

RIG_SCORE: 0.719

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1062H	TCGA-13-1491	OV	TCGA	PTPYAT	DEG_SCF_FBW7_1	0.1111
p.R1062H	TCGA-HW-8322	LGG	TCGA	PTPYAT	DEG_SCF_FBW7_1	0.1111
p.G1068R	TCGA-24-1426	OV	TCGA	PTPYAT	DEG_SCF_FBW7_1	0.2778
p.A1074S	TCGA-86-7713	LUAD	TCGA	PTPYAT	DEG_SCF_FBW7_1	0.6477
p.R1062C	TCGA-A5-A0G2	UCEC	TCGA	PTPYAT	DEG_SCF_FBW7_1	0.1111
p.R1062C	TCGA-AX-A3FT	UCEC	TCGA	PTPYAT	DEG_SCF_FBW7_1	0.1111
p.A1074V	TCGA-DM-A28F	COAD	TCGA	PTPYAT	DEG_SCF_FBW7_1	0.5825
p.G1068W	TCGA-EE-A2GN	SKCM	TCGA	PTPYAT	DEG_SCF_FBW7_1	0.2778
p.V1064G	TCGA-FD-A6TG	BLCA	TCGA	PTPYAT	DEG_SCF_FBW7_1	0.1667
p.A1083T	DO230343	COCA	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.1111
p.G1064E	DO234191	ESAD	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.1667
p.N1081K	DO229037	LICA	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.1667
p.Q1060H	DO52181	LIHC	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.0556
p.A1083S	DO231204	LUSC	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.1111
p.G1064R	DO27373	LUSC	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.1667
p.Q1074H	DO46366	OV	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.7582
p.G1061W	DO38623	STAD	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.0833
p.Q1060R	DO47871	STAD	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.0556
p.N1075S	DO42977	UCEC	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.7069
p.G1061V	DO41999	UCEC	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.0833
p.L1083M	DO41235	UCEC	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.1111
p.Q1063K	DO41373	UCEC	ICGC	PTPYAT	DEG_SCF_FBW7_1	0.1389
p.N1085S	SIDM01175	Other Sarcomas	GDSC	PTPYAT	DEG_SCF_FBW7_1	0.0556
p.N1085S	ACH-002309	Sarcoma	CCLE	PTPYAT	DEG_SCF_FBW7_1	0.0556
p.N1085S	SW684	soft_tissue	COSMIC	PTPYAT	DEG_SCF_FBW7_1	0.0556
p.D1060V	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PTPYAT	DEG_SCF_FBW7_1	0.0556
p.D1060V	NCI-H1703	lung	COSMIC	PTPYAT	DEG_SCF_FBW7_1	0.0556
p.D1060Y	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PTPYAT	DEG_SCF_FBW7_1	0.0556
p.D1060Y	ACH-000747	Lung Cancer	CCLE	PTPYAT	DEG_SCF_FBW7_1	0.0556
p.D1060Y	NCI-H1703	lung	COSMIC	PTPYAT	DEG_SCF_FBW7_1	0.0556
p.D1060F	ACH-000747	Lung Cancer	CCLE	PTPYAT	DEG_SCF_FBW7_1	0.0556
p.P1070S	ACH-000941	Endometrial/Uterine Cancer	CCLE	PTPYAT	DEG_SCF_FBW7_1	0.6752
p.L1083P	ACH-002256	Leukemia	CCLE	PTPYAT	DEG_SCF_FBW7_1	0.1111
p.L1083P	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PTPYAT	DEG_SCF_FBW7_1	0.1111
p.V1064M	RL95-2	endometrium	COSMIC	PTPYAT	DEG_SCF_FBW7_1	0.1667
p.Y1082C	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PTPYAT	DEG_SCF_FBW7_1	0.1389
p.Y1076C	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PTPYAT	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPYAT

Degron related mutations and impact score

Drug responses associated with ROBO1 mutations

All proteins holding degron of PTPYAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6N7	Roundabout homolog 1	DEG_SCF_FBW7_1	1070:1075	PTPYAT	FBXW7	0.993	More...