DegronMD

Uniprot ID: Q9Y6N7

Source protein: Roundabout homolog 1

Source gene: ROBO1

Class: DEG_APCC_DBOX_1

Location: 960:968

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.977

ASA_SCORE: 61.0778

COIL: 0.7582

CONS_SCORE: 0.2828

DSS_SCORE: 0.5175

HELIX: 0.0606

FCONS_SCORE: 0.8955

RIG_SCORE: 0.7077

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A972V	TCGA-AA-3837	COAD	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.A972V	TCGA-VR-AA4D	ESCA	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.A972V	SIDM00817	Kidney Carcinoma	GDSC	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.A972V	ACH-002191	Kidney Cancer	CCLE	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.A972V	RCC-JW	kidney	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.R961M	TCGA-AP-A1DH	UCEC	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	0.8632
p.E954K	TCGA-BG-A18B	UCEC	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	0.1667
p.A972T	TCGA-C8-A8HR	BRCA	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.A972T	SIDM01942	Colorectal Carcinoma	GDSC	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.G952E	TCGA-D8-A1JA	BRCA	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	0.1111
p.G960E	TCGA-EB-A3XB	SKCM	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	0.6087
p.P967Q	DO50341	ESAD	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	0.7035
p.N956I	DO234377	ESAD	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.Q977H	DO233239	GACA	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	0.0833
p.I971L	DO228487	LICA	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	0.25
p.S959R	DO229045	LICA	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	0.3056
p.I971V	DO23290	LINC	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	0.25
p.D975G	DO23146	LINC	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	0.1389
p.D975G	DO45071	LINC	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	0.1389
p.R966C	DO36394	READ	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	0.8301
p.A972S	DO47853	STAD	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.V956A	SIDM00537	Colorectal Carcinoma	GDSC	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.V956A	ACH-000982	Colon/Colorectal Cancer	CCLE	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.V956A	ACH-001345	Colon/Colorectal Cancer	CCLE	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.V956A	GP5d	large_intestine	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	0.2222
p.Q973R	SIDM00534	Colorectal Carcinoma	GDSC	GRPGLLNIS	DEG_APCC_DBOX_1	0.1944
p.Q973R	ACH-000986	Colon/Colorectal Cancer	CCLE	GRPGLLNIS	DEG_APCC_DBOX_1	0.1944
p.Q973R	HT-115	large_intestine	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	0.1944
p.D958N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	0.2778
p.N965S	SW684	soft_tissue	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	0.7069
p.S965I	22RV1	prostate	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	0.7341
p.L963P	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	0.7582
p.N959S	SW684	soft_tissue	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	0.3056
p.L957P	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	0.25
p.S971I	22RV1	prostate	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRPGLLNIS

Degron related mutations and impact score

Drug responses associated with ROBO1 mutations

All proteins holding degron of GRPGLLNIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6N7	Roundabout homolog 1	DEG_APCC_DBOX_1	960:968	GRPGLLNIS	APC,CDC20,FZR1	0.977	More...