DegronMD

Uniprot ID: Q9Y6N7

Source protein: Roundabout homolog 1

Source gene: ROBO1

Class: DEG_Kelch_Keap1_1

Location: 1091:1096

E3 ligase: KEAP1

DEGRON score: 0.9173

ASA_SCORE: 74.0167

COIL: 0.8642

CONS_SCORE: 0.2027

DSS_SCORE: 0.6956

HELIX: 0.1

FCONS_SCORE: 0.6853

RIG_SCORE: 0.5567

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1103R	TCGA-18-5595	LUSC	TCGA	SGDSGE	DEG_Kelch_Keap1_1	0.1389
p.P1101S	TCGA-5M-AAT6	COAD	TCGA	SGDSGE	DEG_Kelch_Keap1_1	0.1944
p.Q1105R	TCGA-BR-A4QM	STAD	TCGA	SGDSGE	DEG_Kelch_Keap1_1	0.0833
p.Q1105H	TCGA-CC-A7IH	LIHC	TCGA	SGDSGE	DEG_Kelch_Keap1_1	0.0833
p.A1083T	DO230343	COCA	ICGC	SGDSGE	DEG_Kelch_Keap1_1	0.1111
p.Q1101K	DO229019	LICA	ICGC	SGDSGE	DEG_Kelch_Keap1_1	0.1944
p.P1094T	DO229019	LICA	ICGC	SGDSGE	DEG_Kelch_Keap1_1	0.7031
p.A1089E	DO229019	LICA	ICGC	SGDSGE	DEG_Kelch_Keap1_1	0.2778
p.A1089E	DO229034	LICA	ICGC	SGDSGE	DEG_Kelch_Keap1_1	0.2778
p.N1081K	DO229037	LICA	ICGC	SGDSGE	DEG_Kelch_Keap1_1	0.0556
p.S1104P	DO45139	LIRI	ICGC	SGDSGE	DEG_Kelch_Keap1_1	0.1111
p.A1083S	DO231204	LUSC	ICGC	SGDSGE	DEG_Kelch_Keap1_1	0.1111
p.Y1093H	DO26587	LUSC	ICGC	SGDSGE	DEG_Kelch_Keap1_1	0.7229
p.P1088L	DO47625	SKCM	ICGC	SGDSGE	DEG_Kelch_Keap1_1	0.25
p.L1083M	DO41235	UCEC	ICGC	SGDSGE	DEG_Kelch_Keap1_1	0.1111
p.S1091I	SIDM00499	Prostate Carcinoma	GDSC	SGDSGE	DEG_Kelch_Keap1_1	0.7341
p.S1091I	22RV1	prostate	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	0.7341
p.N1085S	SIDM01175	Other Sarcomas	GDSC	SGDSGE	DEG_Kelch_Keap1_1	0.1667
p.N1085S	ACH-002309	Sarcoma	CCLE	SGDSGE	DEG_Kelch_Keap1_1	0.1667
p.N1085S	SW684	soft_tissue	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	0.1667
p.L1083P	ACH-002256	Leukemia	CCLE	SGDSGE	DEG_Kelch_Keap1_1	0.1111
p.L1083P	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	0.1111
p.V1098M	PSN1	pancreas	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	0.2778
p.V1098M	OVKATE	ovary	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	0.2778
p.V1092M	PSN1	pancreas	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	0.7208
p.V1092M	OVKATE	ovary	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	0.7208
p.N1094K	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	0.6918
p.Y1102C	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	0.1667
p.Y1082C	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SGDSGE

Degron related mutations and impact score

Drug responses associated with ROBO1 mutations

All proteins holding degron of SGDSGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6N7	Roundabout homolog 1	DEG_Kelch_Keap1_1	1091:1096	SGDSGE	KEAP1	0.9173	More...