DegronMD - Q16625(OCLN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P346L	TCGA-B7-A5TI	STAD	TCGA	ESSYKSTPVPEV	DEG_COP1_1	339:350	Mutation altering degron motif	0.6471
p.P9S	TCGA-BR-8591	STAD	TCGA	PPPY	ITCH	9:12	Mutation altering degron motif	0.6752
p.P9S	DO47973	STAD	ICGC	PPPY	ITCH	9:12	Mutation altering degron motif	0.6752
p.S358L	TCGA-D3-A8GC	SKCM	TCGA	ESSYKSTPVPEV	DEG_COP1_1	339:350	Mutation blocking phosphorylation signal	0.5556
p.S358L	TCGA-FS-A4FC	SKCM	TCGA	ESSYKSTPVPEV	DEG_COP1_1	339:350	Mutation blocking phosphorylation signal	0.5556
p.S358L	DO37762	SKCM	ICGC	ESSYKSTPVPEV	DEG_COP1_1	339:350	Mutation blocking phosphorylation signal	0.5556
p.S358L	DO50281	SKCM	ICGC	ESSYKSTPVPEV	DEG_COP1_1	339:350	Mutation blocking phosphorylation signal	0.5556
p.S341F	TCGA-D3-A8GI	SKCM	TCGA	ESSYKSTPVPEV	DEG_COP1_1	339:350	Mutation altering degron motif	0.9093
p.S341F	TCGA-EB-A44P	SKCM	TCGA	ESSYKSTPVPEV	DEG_COP1_1	339:350	Mutation altering degron motif	0.9093
p.S3C	TCGA-D8-A27G	BRCA	TCGA	PPPY	ITCH	9:12	Mutation rewiring degron network	0.1667
p.R318I	TCGA-DA-A1I5	SKCM	TCGA	SAGTQDVPSP	DEG_COP1_1	302:311	Mutation rewiring degron network	0.1389
p.V294I	TCGA-DY-A0XA	READ	TCGA	SAGTQDVPSP	DEG_COP1_1	302:311	Mutation rewiring degron network	0.1111
p.P292T	TCGA-E2-A14Z	BRCA	TCGA	SAGTQDVPSP	DEG_COP1_1	302:311	Mutation rewiring degron network	0.0556
p.P292T	DO4221	BRCA	ICGC	SAGTQDVPSP	DEG_COP1_1	302:311	Mutation rewiring degron network	0.0556
p.V316A	TCGA-E6-A1LX	UCEC	TCGA	SAGTQDVPSP	DEG_COP1_1	302:311	Mutation rewiring degron network	0.1944
p.P14H	TCGA-EE-A20F	SKCM	TCGA	PPPY	ITCH	9:12	Mutation rewiring degron network	0.2778
p.P14S	TCGA-FI-A2D5	UCEC	TCGA	PPPY	ITCH	9:12	Mutation rewiring degron network	0.2778
p.P14S	DO41331	UCEC	ICGC	PPPY	ITCH	9:12	Mutation rewiring degron network	0.2778
p.D307N	TCGA-FR-A8YC	SKCM	TCGA	SAGTQDVPSP	DEG_COP1_1	302:311	Mutation altering degron motif	0.5821
p.D307N	DO50301	SKCM	ICGC	SAGTQDVPSP	DEG_COP1_1	302:311	Mutation altering degron motif	0.5821
p.E16K	TCGA-FW-A3R5	SKCM	TCGA	PPPY	ITCH	9:12	Mutation rewiring degron network	0.2222
p.E16K	DO37406	SKCM	ICGC	PPPY	ITCH	9:12	Mutation rewiring degron network	0.2222
p.P355S	TCGA-FW-A3R5	SKCM	TCGA	ESSYKSTPVPEV	DEG_COP1_1	339:350	Mutation rewiring degron network	0.1944
p.P355S	DO37406	SKCM	ICGC	ESSYKSTPVPEV	DEG_COP1_1	339:350	Mutation rewiring degron network	0.1944
p.H21R	DO23242	LINC	ICGC	PPPY	ITCH	9:12	Mutation rewiring degron network	0.0833
p.L6F	DO222749	MELA	ICGC	PPPY	ITCH	9:12	Mutation rewiring degron network	0.25
p.S19F	DO50284	SKCM	ICGC	PPPY	ITCH	9:12	Mutation rewiring degron network	0.1389
p.S19F	DO47525	SKCM	ICGC	PPPY	ITCH	9:12	Mutation rewiring degron network	0.1389
p.S5F	DO38123	SKCM	ICGC	PPPY	ITCH	9:12	Mutation rewiring degron network	0.2222
p.D21G	DO38579	STAD	ICGC	PPPY	ITCH	9:12	Mutation rewiring degron network	0.0833
p.T345M	SIDM01307	Colorectal Carcinoma	GDSC	ESSYKSTPVPEV	DEG_COP1_1	339:350	Mutation altering degron motif	0.7423
p.W297L	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	SAGTQDVPSP	DEG_COP1_1	302:311	Mutation rewiring degron network	0.1944
p.W297L	NCI-H358	lung	COSMIC	SAGTQDVPSP	DEG_COP1_1	302:311	Mutation rewiring degron network	0.1944
p.P11H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	9:12	Mutation altering degron motif	0.6583
p.P19L	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	9:12	Mutation rewiring degron network	0.1389
p.P19L	ACH-000937	Leukemia	CCLE	PPPY	ITCH	9:12	Mutation rewiring degron network	0.1389
p.P19L	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	9:12	Mutation rewiring degron network	0.1389
p.R459C	ACH-000624	Breast Cancer	CCLE	DYR	CBL_MET	466:468	Mutation rewiring degron network	0.1389
p.V308M	NCI-H810	lung	COSMIC	SAGTQDVPSP	DEG_COP1_1	302:311	Mutation altering degron motif	0.7208
p.V308M	NB5	autonomic ganglia	COSMIC	SAGTQDVPSP	DEG_COP1_1	302:311	Mutation altering degron motif	0.7208
p.F11L	H3118	upper aerodigestive tract	COSMIC	PPPY	ITCH	9:12	Mutation altering degron motif	0.6981

Kaplan plot for OCLN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OCLN

UniProt ID: Q16625

Entrez ID: 100506658

Protein name: Occludin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OCLN in