DegronMD

Uniprot ID: Q16625

Source protein: Occludin

Source gene: OCLN

Class: DEG_COP1_1

Location: 302:311

E3 ligase: COP1

DEGRON score: 0.9288

ASA_SCORE: 79.51

COIL: 0.8883

CONS_SCORE: 0.4331

DSS_SCORE: 0.5757

HELIX: 0.0414

FCONS_SCORE: 0.7077

RIG_SCORE: 0.6441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R318I	TCGA-DA-A1I5	SKCM	TCGA	SAGTQDVPSP	DEG_COP1_1	0.1389
p.V294I	TCGA-DY-A0XA	READ	TCGA	SAGTQDVPSP	DEG_COP1_1	0.1111
p.P292T	TCGA-E2-A14Z	BRCA	TCGA	SAGTQDVPSP	DEG_COP1_1	0.0556
p.P292T	DO4221	BRCA	ICGC	SAGTQDVPSP	DEG_COP1_1	0.0556
p.V316A	TCGA-E6-A1LX	UCEC	TCGA	SAGTQDVPSP	DEG_COP1_1	0.1944
p.D307N	TCGA-FR-A8YC	SKCM	TCGA	SAGTQDVPSP	DEG_COP1_1	0.5821
p.D307N	DO50301	SKCM	ICGC	SAGTQDVPSP	DEG_COP1_1	0.5821
p.W297L	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	SAGTQDVPSP	DEG_COP1_1	0.1944
p.W297L	NCI-H358	lung	COSMIC	SAGTQDVPSP	DEG_COP1_1	0.1944
p.V308M	NCI-H810	lung	COSMIC	SAGTQDVPSP	DEG_COP1_1	0.7208
p.V308M	NB5	autonomic_ganglia	COSMIC	SAGTQDVPSP	DEG_COP1_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16625	Occludin	DEG_COP1_1	302:311	SAGTQDVPSP	COP1	0.9288	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons