DegronMD

Uniprot ID: Q16625

Source protein: Occludin

Source gene: OCLN

Class: DEG_COP1_1

Location: 339:350

E3 ligase: COP1

DEGRON score: 0.9911

ASA_SCORE: 92.4917

COIL: 0.8807

CONS_SCORE: 0.5141

DSS_SCORE: 0.5021

HELIX: 0.1008

FCONS_SCORE: 1.1555

RIG_SCORE: 0.6964

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P346L	TCGA-B7-A5TI	STAD	TCGA	ESSYKSTPVPEV	DEG_COP1_1	0.6471
p.S358L	TCGA-D3-A8GC	SKCM	TCGA	ESSYKSTPVPEV	DEG_COP1_1	0.5556
p.S358L	TCGA-FS-A4FC	SKCM	TCGA	ESSYKSTPVPEV	DEG_COP1_1	0.5556
p.S358L	DO37762	SKCM	ICGC	ESSYKSTPVPEV	DEG_COP1_1	0.5556
p.S358L	DO50281	SKCM	ICGC	ESSYKSTPVPEV	DEG_COP1_1	0.5556
p.S341F	TCGA-D3-A8GI	SKCM	TCGA	ESSYKSTPVPEV	DEG_COP1_1	0.9093
p.S341F	TCGA-EB-A44P	SKCM	TCGA	ESSYKSTPVPEV	DEG_COP1_1	0.9093
p.P355S	TCGA-FW-A3R5	SKCM	TCGA	ESSYKSTPVPEV	DEG_COP1_1	0.1944
p.P355S	DO37406	SKCM	ICGC	ESSYKSTPVPEV	DEG_COP1_1	0.1944
p.T345M	SIDM01307	Colorectal Carcinoma	GDSC	ESSYKSTPVPEV	DEG_COP1_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16625	Occludin	DEG_COP1_1	339:350	ESSYKSTPVPEV	COP1	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons