DegronMD - P98175(RBM10)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V569I	TCGA-06-0119	GBM	TCGA	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation altering degron motif	0.5965
p.V333I	TCGA-19-5956	GBM	TCGA	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2222
p.V333I	TCGA-AA-3811	COAD	TCGA	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2222
p.V333I	ACH-000920	Leukemia	CCLE	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2222
p.V333I	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2222
p.E118D	TCGA-2G-AALF	TGCT	TCGA	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.0556
p.E118D	TCGA-HU-A4GT	STAD	TCGA	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.0556
p.E118D	DO48020	STAD	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.0556
p.E110D	TCGA-60-2695	LUSC	TCGA	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1389
p.E110D	TCGA-60-2695	LUSC	TCGA	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.2778
p.E110D	TCGA-AX-A2HC	UCEC	TCGA	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1389
p.E110D	TCGA-AX-A2HC	UCEC	TCGA	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.2778
p.E110D	DO26665	LUSC	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1389
p.E110D	DO26665	LUSC	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.2778
p.E110D	DO41572	UCEC	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1389
p.E110D	DO41572	UCEC	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.2778
p.G49S	TCGA-78-7220	LUAD	TCGA	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.1389
p.G49S	DO24409	LUAD	ICGC	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.1389
p.R30C	TCGA-A5-A0G2	UCEC	TCGA	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.1944
p.R30C	TCGA-A5-A0G2	UCEC	TCGA	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.0556
p.R30C	DO41235	UCEC	ICGC	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.1944
p.R30C	DO41235	UCEC	ICGC	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.0556
p.S570Y	TCGA-A5-A1OF	UCEC	TCGA	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.3056
p.D35N	TCGA-AN-A046	BRCA	TCGA	DYR	CBL_MET	35:37	Mutation altering degron motif	0.6932
p.D35N	DO1285	BRCA	ICGC	DYR	CBL_MET	35:37	Mutation altering degron motif	0.6932
p.D575V	TCGA-AP-A054	UCEC	TCGA	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.1667
p.R30H	TCGA-AP-A1DV	UCEC	TCGA	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.1944
p.R30H	TCGA-AP-A1DV	UCEC	TCGA	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.0556
p.R30H	TCGA-EO-A22U	UCEC	TCGA	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.1944
p.R30H	TCGA-EO-A22U	UCEC	TCGA	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.0556
p.R30H	DO233884	GACA	ICGC	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.1944
p.R30H	DO233884	GACA	ICGC	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.0556
p.R30H	DO43186	UCEC	ICGC	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.1944
p.R30H	DO43186	UCEC	ICGC	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.0556
p.R30H	DO43755	UCEC	ICGC	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.1944
p.R30H	DO43755	UCEC	ICGC	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.0556
p.D336G	TCGA-AP-A1DV	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1389
p.G100S	TCGA-AX-A06F	UCEC	TCGA	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.3056
p.G100S	TCGA-AX-A06F	UCEC	TCGA	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.1667
p.G100S	DO41752	UCEC	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.3056
p.G100S	DO41752	UCEC	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.1667
p.A319V	TCGA-AX-A3G8	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1667
p.D568N	TCGA-AZ-4615	COAD	TCGA	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation altering degron motif	0.6932
p.D568N	TCGA-BR-8680	STAD	TCGA	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation altering degron motif	0.6932
p.R46H	TCGA-C8-A3M8	BRCA	TCGA	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.0833
p.R46H	TCGA-C8-A3M8	BRCA	TCGA	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.2222
p.R46H	DO44117	BRCA	ICGC	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.0833
p.R46H	DO44117	BRCA	ICGC	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.2222
p.R108Q	TCGA-CG-5721	STAD	TCGA	DYR	CBL_MET	106:108	Mutation altering degron motif	0.7329
p.R108Q	DO38192	STAD	ICGC	DYR	CBL_MET	106:108	Mutation altering degron motif	0.7329
p.Y564F	TCGA-DD-AAVV	LIHC	TCGA	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation altering degron motif	0.6417
p.D25G	TCGA-DI-A1BU	UCEC	TCGA	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.0556
p.D25G	DO42023	UCEC	ICGC	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.0556
p.S315F	TCGA-EE-A2GL	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.0556
p.T556S	TCGA-EE-A2MQ	SKCM	TCGA	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation blocking phosphorylation signal	0.6944
p.P565T	TCGA-EO-A3AU	UCEC	TCGA	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation altering degron motif	0.5919
p.G579S	TCGA-G4-6302	COAD	TCGA	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.0556
p.P97L	DO225213	BRCA	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.2222
p.P97L	DO225213	BRCA	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.0833
p.P97L	DO227529	BRCA	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.2222
p.P97L	DO227529	BRCA	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.0833
p.A321V	DO9010	COAD	ICGC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2222
p.R42S	DO233207	GACA	ICGC	DYR	CBL_MET	40:42	Mutation altering degron motif	0.7427
p.R37W	DO233864	GACA	ICGC	DYR	CBL_MET	35:37	Mutation altering degron motif	0.8634
p.M39I	DO229019	LICA	ICGC	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.2778
p.M39I	DO229019	LICA	ICGC	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.3056
p.M111I	DO229031	LICA	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1111
p.M111I	DO229031	LICA	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.25
p.A107S	DO229038	LICA	ICGC	DYR	CBL_MET	106:108	Mutation altering degron motif	0.7588
p.G112E	DO229052	LICA	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.0833
p.G112E	DO229052	LICA	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.2222
p.G91V	DO229009	LICA	ICGC	DYR	CBL_MET	101:103	Mutation blocking phosphorylation signal	0.5
p.I319V	DO231583	LINC	ICGC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1667
p.H116Y	DO23450	LINC	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.1111
p.Q338L	DO24297	LUAD	ICGC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.0833
p.E116D	DO50674	ORCA	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.1111
p.S555L	DO28621	OV	ICGC	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.2222
p.R318H	DO46657	PAAD	ICGC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1389
p.R318H	DO43578	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1389
p.R318H	LS-411N	large intestine	COSMIC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1389
p.V99D	DO49145	PACA	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.2778
p.V99D	DO49145	PACA	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.1389
p.R579L	DO49075	PACA	ICGC	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.0556
p.I336F	DO35138	PACA	ICGC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1389
p.W110C	DO51532	PACA	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1389
p.W110C	DO51532	PACA	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.2778
p.E578K	DO37535	SKCM	ICGC	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.0833
p.R94W	DO37839	SKCM	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1389
p.R94W	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1389
p.E560K	DO219482	SKCM	ICGC	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation altering degron motif	0.7022
p.A574T	DO47769	STAD	ICGC	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.1944
p.D576G	DO229257	THCA	ICGC	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.1389
p.E100K	DO50076	UCEC	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.3056
p.E100K	DO50076	UCEC	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.1667
p.E100K	DO41020	UCEC	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.3056
p.E100K	DO41020	UCEC	ICGC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.1667
p.R318C	DO43306	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1389
p.S323Y	DO41572	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2778
p.E557D	DO41847	UCEC	ICGC	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.2778
p.G571V	SIDM00210	Ovarian Carcinoma	GDSC	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.2778
p.G571V	A2780	ovary	COSMIC	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.2778
p.P336T	SIDM00820	Kidney Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1389
p.P336T	RCC-ER	kidney	COSMIC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1389
p.P336L	SIDM00820	Kidney Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1389
p.P336L	RCC-ER	kidney	COSMIC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1389
p.Y101F	SIDM01113	Other Sarcomas	GDSC	DYR	CBL_MET	101:103	Mutation altering degron motif	0.7528
p.Y101F	SK-UT-1	soft tissue	COSMIC	DYR	CBL_MET	101:103	Mutation altering degron motif	0.7528
p.P110L	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1389
p.P110L	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.2778
p.P110L	NCI-H1437	lung	COSMIC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1389
p.P110L	NCI-H1437	lung	COSMIC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.2778
p.G41E	SIDM00438	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	40:42	Mutation altering degron motif	0.7199
p.G41E	MN-60	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	40:42	Mutation altering degron motif	0.7199
p.R332L	ACH-000314	Lung Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.25
p.P45L	ACH-000589	Lung Cancer	CCLE	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.1111
p.P45L	ACH-000589	Lung Cancer	CCLE	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.25
p.P45L	NCI-H1437	lung	COSMIC	DYR	CBL_MET	35:37	Mutation rewiring degron network	0.1111
p.P45L	NCI-H1437	lung	COSMIC	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.25
p.S562N	ACH-000880	Gastric Cancer	CCLE	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation altering degron motif	0.7069
p.S562N	AGS	stomach	COSMIC	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation altering degron motif	0.7069
p.A552V	ACH-000912	Lung Cancer	CCLE	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.1389
p.Y36F	ACH-000939	Sarcoma	CCLE	DYR	CBL_MET	35:37	Mutation altering degron motif	0.8639
p.Y36F	SK-UT-1	soft tissue	COSMIC	DYR	CBL_MET	35:37	Mutation altering degron motif	0.8639
p.D575G	ACH-000982	Colon/Colorectal Cancer	CCLE	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.1667
p.D575G	ACH-001345	Colon/Colorectal Cancer	CCLE	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.1667
p.D575G	GP5d	large intestine	COSMIC	ESYSQYPVPDV	DEG_COP1_1	559:569	Mutation rewiring degron network	0.1667
p.R42H	ACH-001518	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	40:42	Mutation altering degron motif	0.8244
p.R103W	ACH-001786	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	101:103	Mutation altering degron motif	0.8634
p.N315S	HAL-01	haematopoietic and lymphoid tissue	COSMIC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.0556
p.N315S	ASH-3	thyroid	COSMIC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.0556
p.N315S	SNU-407	large intestine	COSMIC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.0556
p.N315S	CMK	haematopoietic and lymphoid tissue	COSMIC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.0556
p.N315S	KMH-2	thyroid	COSMIC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.0556
p.A331V	MFE-319	endometrium	COSMIC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2778
p.A332V	MFE-319	endometrium	COSMIC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.25
p.R319H	LS-411N	large intestine	COSMIC	VLSSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1667
p.S117F	Mewo	skin	COSMIC	DYR	CBL_MET	106:108	Mutation rewiring degron network	0.0833
p.R94Q	NCI-H1435	lung	COSMIC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1389
p.R51Q	NCI-H630	large intestine	COSMIC	DYR	CBL_MET	40:42	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM10

UniProt ID: P98175

Entrez ID: 8241

Protein name: RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM10 in