DegronMD

Uniprot ID: P98175

Source protein: RNA-binding protein 10

Source gene: RBM10

Class: DEG_COP1_1

Location: 559:569

E3 ligase: COP1

DEGRON score: 0.9862

ASA_SCORE: 69.6182

COIL: 0.7928

CONS_SCORE: 0.263

DSS_SCORE: 0.5622

HELIX: 0.0758

FCONS_SCORE: 0.9265

RIG_SCORE: 0.6998

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V569I	TCGA-06-0119	GBM	TCGA	ESYSQYPVPDV	DEG_COP1_1	0.5965
p.S570Y	TCGA-A5-A1OF	UCEC	TCGA	ESYSQYPVPDV	DEG_COP1_1	0.3056
p.D575V	TCGA-AP-A054	UCEC	TCGA	ESYSQYPVPDV	DEG_COP1_1	0.1667
p.D568N	TCGA-AZ-4615	COAD	TCGA	ESYSQYPVPDV	DEG_COP1_1	0.6932
p.D568N	TCGA-BR-8680	STAD	TCGA	ESYSQYPVPDV	DEG_COP1_1	0.6932
p.Y564F	TCGA-DD-AAVV	LIHC	TCGA	ESYSQYPVPDV	DEG_COP1_1	0.6417
p.T556S	TCGA-EE-A2MQ	SKCM	TCGA	ESYSQYPVPDV	DEG_COP1_1	0.6944
p.P565T	TCGA-EO-A3AU	UCEC	TCGA	ESYSQYPVPDV	DEG_COP1_1	0.5919
p.G579S	TCGA-G4-6302	COAD	TCGA	ESYSQYPVPDV	DEG_COP1_1	0.0556
p.S555L	DO28621	OV	ICGC	ESYSQYPVPDV	DEG_COP1_1	0.2222
p.R579L	DO49075	PACA	ICGC	ESYSQYPVPDV	DEG_COP1_1	0.0556
p.E578K	DO37535	SKCM	ICGC	ESYSQYPVPDV	DEG_COP1_1	0.0833
p.E560K	DO219482	SKCM	ICGC	ESYSQYPVPDV	DEG_COP1_1	0.7022
p.A574T	DO47769	STAD	ICGC	ESYSQYPVPDV	DEG_COP1_1	0.1944
p.D576G	DO229257	THCA	ICGC	ESYSQYPVPDV	DEG_COP1_1	0.1389
p.E557D	DO41847	UCEC	ICGC	ESYSQYPVPDV	DEG_COP1_1	0.2778
p.G571V	SIDM00210	Ovarian Carcinoma	GDSC	ESYSQYPVPDV	DEG_COP1_1	0.2778
p.G571V	A2780	ovary	COSMIC	ESYSQYPVPDV	DEG_COP1_1	0.2778
p.S562N	ACH-000880	Gastric Cancer	CCLE	ESYSQYPVPDV	DEG_COP1_1	0.7069
p.S562N	AGS	stomach	COSMIC	ESYSQYPVPDV	DEG_COP1_1	0.7069
p.A552V	ACH-000912	Lung Cancer	CCLE	ESYSQYPVPDV	DEG_COP1_1	0.1389
p.D575G	ACH-000982	Colon/Colorectal Cancer	CCLE	ESYSQYPVPDV	DEG_COP1_1	0.1667
p.D575G	ACH-001345	Colon/Colorectal Cancer	CCLE	ESYSQYPVPDV	DEG_COP1_1	0.1667
p.D575G	GP5d	large_intestine	COSMIC	ESYSQYPVPDV	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98175	RNA-binding protein 10	DEG_COP1_1	559:569	ESYSQYPVPDV	COP1	0.9862	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons