DegronMD - P08581(MET)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V13L	TCGA-A6-4105	COAD	TCGA	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation altering degron motif	0.5654
p.V13L	DO10670	COAD	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation altering degron motif	0.5654
p.V13L	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation altering degron motif	0.5654
p.V13L	ACH-000733	Lung Cancer	CCLE	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation altering degron motif	0.5654
p.V13L	NCI-H1838	lung	COSMIC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation altering degron motif	0.5654
p.R992T	TCGA-AC-A23H	BRCA	TCGA	DYR	CBL_MET	1002:1004	Mutation blocking phosphorylation signal	0.5
p.R21M	TCGA-AP-A0LM	UCEC	TCGA	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation rewiring degron network	0.25
p.R21M	DO43306	UCEC	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation rewiring degron network	0.25
p.K2N	TCGA-AX-A3G3	UCEC	TCGA	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation substituting flanking lysine	0.3056
p.K2N	DO41050	UCEC	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation substituting flanking lysine	0.3056
p.A3V	TCGA-BG-A222	UCEC	TCGA	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation substituting flanking lysine	0.3333
p.A3V	DO42977	UCEC	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation substituting flanking lysine	0.3333
p.V1014I	TCGA-D3-A2JN	SKCM	TCGA	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.0556
p.E1012K	TCGA-EE-A2GM	SKCM	TCGA	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.1111
p.R1000M	TCGA-EY-A215	UCEC	TCGA	DYR	CBL_MET	1002:1004	Mutation blocking phosphorylation signal	0.7222
p.S22I	TCGA-RC-A7SK	LIHC	TCGA	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation rewiring degron network	0.2222
p.S22I	DO52314	LIHC	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation rewiring degron network	0.2222
p.E28V	DO225339	BRCA	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation rewiring degron network	0.0556
p.D1002N	DO224685	COCA	ICGC	DYR	CBL_MET	1002:1004	Mutation altering degron motif	0.6932
p.M995I	DO52450	COCA	ICGC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.1389
p.M995I	DO35747	PBCA	ICGC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.1389
p.A5T	DO233864	GACA	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation rewiring degron network	0.2778
p.G24V	DO228978	LICA	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation rewiring degron network	0.1667
p.G10V	DO229034	LICA	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation altering degron motif	0.6421
p.E994K	DO220855	MELA	ICGC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.1111
p.E994K	DO37555	SKCM	ICGC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.1111
p.P1008S	DO222557	MELA	ICGC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.2222
p.D1002G	DO49203	PACA	ICGC	DYR	CBL_MET	1002:1004	Mutation altering degron motif	0.7198
p.R1004Q	DO232630	PBCA	ICGC	DYR	CBL_MET	1002:1004	Mutation altering degron motif	0.7329
p.R1004Q	DO43106	UCEC	ICGC	DYR	CBL_MET	1002:1004	Mutation altering degron motif	0.7329
p.N1014S	DO37018	READ	ICGC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.0556
p.P1013S	DO37487	SKCM	ICGC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.0833
p.V996I	DO47590	SKCM	ICGC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.1667
p.V1007I	SIDM00477	Esophageal Carcinoma	GDSC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.25
p.V1007I	ACH-000383	Esophageal Cancer	CCLE	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.25
p.V1007I	TE-9	oesophagus	COSMIC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.25
p.V1007I	OE33	oesophagus	COSMIC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.25
p.T17I	SIDM01087	Melanoma	GDSC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation altering degron motif	0.7078
p.T17I	ACH-000348	Skin Cancer	CCLE	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation altering degron motif	0.7078
p.T17I	RPMI-7951	skin	COSMIC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation altering degron motif	0.7078
p.G24E	SIDM00254	Neuroblastoma	GDSC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation rewiring degron network	0.1667
p.G24E	SIDM01173	Rhabdomyosarcoma	GDSC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation rewiring degron network	0.1667
p.G24E	SIDM01409	Bladder Carcinoma	GDSC	LAPGILVLLFTL	DEG_ODPH_VHL_1	7:18	Mutation rewiring degron network	0.1667
p.P1009S	SIDM00279	Gastric Carcinoma	GDSC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.1944
p.P1009S	ACH-000225	Gastric Cancer	CCLE	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.1944
p.P1009S	ECC12	stomach	COSMIC	DYR	CBL_MET	1002:1004	Mutation rewiring degron network	0.1944

Kaplan plot for MET in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MET

UniProt ID: P08581

Entrez ID: 4233

Protein name: Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MET in