DegronMD

Uniprot ID: P08581

Source protein: Hepatocyte growth factor receptor

Source gene: MET

Class: DEG_ODPH_VHL_1

Location: 7:18

E3 ligase: VHL

DEGRON score: 0.7514

ASA_SCORE: 55.7417

COIL: 0.0359

CONS_SCORE: 0.4279

DSS_SCORE: 0.0398

HELIX: 0.9614

FCONS_SCORE: 1.1902

RIG_SCORE: 0.9164

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V13L	TCGA-A6-4105	COAD	TCGA	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.5654
p.V13L	DO10670	COAD	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.5654
p.V13L	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.5654
p.V13L	ACH-000733	Lung Cancer	CCLE	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.5654
p.V13L	NCI-H1838	lung	COSMIC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.5654
p.R21M	TCGA-AP-A0LM	UCEC	TCGA	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.25
p.R21M	DO43306	UCEC	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.25
p.K2N	TCGA-AX-A3G3	UCEC	TCGA	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.3056
p.K2N	DO41050	UCEC	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.3056
p.A3V	TCGA-BG-A222	UCEC	TCGA	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.3333
p.A3V	DO42977	UCEC	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.3333
p.S22I	TCGA-RC-A7SK	LIHC	TCGA	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.2222
p.S22I	DO52314	LIHC	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.2222
p.E28V	DO225339	BRCA	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.0556
p.A5T	DO233864	GACA	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.2778
p.G24V	DO228978	LICA	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.1667
p.G10V	DO229034	LICA	ICGC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.6421
p.T17I	SIDM01087	Melanoma	GDSC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.7078
p.T17I	ACH-000348	Skin Cancer	CCLE	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.7078
p.T17I	RPMI-7951	skin	COSMIC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.7078
p.G24E	SIDM00254	Neuroblastoma	GDSC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.1667
p.G24E	SIDM01173	Rhabdomyosarcoma	GDSC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.1667
p.G24E	SIDM01409	Bladder Carcinoma	GDSC	LAPGILVLLFTL	DEG_ODPH_VHL_1	0.1667

Drug responses associated with MET mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000348	Skin Cancer	p.T17I (Yes)	CCLE	PHA-665752	8
ACH-000348	Skin Cancer	p.T17I (Yes)	CCLE	PF2341066	4.2529
ACH-000007	Colon/Colorectal Cancer	p.E34K (No)	CCLE	PHA-665752	8
ACH-000007	Colon/Colorectal Cancer	p.E34K (No)	CCLE	PF2341066	7.2532
ACH-000985	Colon/Colorectal Cancer	p.T86I (No)	CCLE	PHA-665752	8
ACH-000985	Colon/Colorectal Cancer	p.T86I (No)	CCLE	PF2341066	8
ACH-000988	Endometrial/Uterine Cancer	p.S135N (No)	CCLE	PHA-665752	8
ACH-000988	Endometrial/Uterine Cancer	p.S135N (No)	CCLE	PF2341066	8
ACH-000995	Leukemia	p.H159R (No)	CCLE	PHA-665752	4.2212
ACH-000995	Leukemia	p.H159R (No)	CCLE	PF2341066	1.6869
ACH-000953	Leukemia	p.R191W (No)	CCLE	PHA-665752	8
ACH-000953	Leukemia	p.R191W (No)	CCLE	PF2341066	8
ACH-000652	Pancreatic Cancer	p.T200A (No)	CCLE	PHA-665752	7.3654
ACH-000652	Pancreatic Cancer	p.T200A (No)	CCLE	PF2341066	8
ACH-000971	Colon/Colorectal Cancer	p.V237fs (No)	CCLE	PHA-665752	8
ACH-000971	Colon/Colorectal Cancer	p.V237fs (No)	CCLE	PF2341066	7.0497
ACH-001021	Liver Cancer	p.S244Y (No)	CCLE	PHA-665752	8
ACH-001021	Liver Cancer	p.S244Y (No)	CCLE	PF2341066	8
ACH-000253	Colon/Colorectal Cancer	p.I333L (No)	CCLE	PHA-665752	8
ACH-000253	Colon/Colorectal Cancer	p.I333L (No)	CCLE	PF2341066	5.8932
ACH-001039	Colon/Colorectal Cancer	p.I333L (No)	CCLE	PHA-665752	8
ACH-001039	Colon/Colorectal Cancer	p.I333L (No)	CCLE	PF2341066	3.6586
ACH-000940	Endometrial/Uterine Cancer	p.G344R (No)	CCLE	PHA-665752	8
ACH-000940	Endometrial/Uterine Cancer	p.G344R (No)	CCLE	PF2341066	8
ACH-001187	Fibroblast	p.E355K (No)	CCLE	PHA-665752	8
ACH-001187	Fibroblast	p.E355K (No)	CCLE	PF2341066	8
ACH-000987	Skin Cancer	p.P366S (No)	CCLE	PHA-665752	8
ACH-000987	Skin Cancer	p.P366S (No)	CCLE	PF2341066	8
ACH-001306	Thyroid Cancer	p.PDTSEKF401fs (No)	CCLE	PHA-665752	8
ACH-001306	Thyroid Cancer	p.PDTSEKF401fs (No)	CCLE	PF2341066	6.2365
ACH-000758	Gastric Cancer	p.G456fs (No)	CCLE	PHA-665752	8
ACH-000758	Gastric Cancer	p.G456fs (No)	CCLE	PF2341066	8
ACH-000931	Skin Cancer	p.P472S (No)	CCLE	PHA-665752	8
ACH-000931	Skin Cancer	p.P472S (No)	CCLE	PF2341066	7.9873
ACH-000931	Skin Cancer	p.E493K (No)	CCLE	PHA-665752	8
ACH-000931	Skin Cancer	p.E493K (No)	CCLE	PF2341066	7.9873
ACH-001024	Skin Cancer	p.E493K (No)	CCLE	PHA-665752	8
ACH-001024	Skin Cancer	p.E493K (No)	CCLE	PF2341066	8
ACH-000583	Lymphoma	p.L530V (No)	CCLE	PHA-665752	8
ACH-000583	Lymphoma	p.L530V (No)	CCLE	PF2341066	8
ACH-000353	Esophageal Cancer	p.K595T (No)	CCLE	PHA-665752	8
ACH-000353	Esophageal Cancer	p.K595T (No)	CCLE	PF2341066	8
ACH-000118	Pancreatic Cancer	p.M636V (No)	CCLE	PHA-665752	8
ACH-000118	Pancreatic Cancer	p.M636V (No)	CCLE	PF2341066	8
ACH-000996	Endometrial/Uterine Cancer	p.F753C (No)	CCLE	PHA-665752	8
ACH-000996	Endometrial/Uterine Cancer	p.F753C (No)	CCLE	PF2341066	8
ACH-001024	Skin Cancer	p.P761S (No)	CCLE	PHA-665752	8
ACH-001024	Skin Cancer	p.P761S (No)	CCLE	PF2341066	8
ACH-000408	Esophageal Cancer	p.E815D (No)	CCLE	PHA-665752	8
ACH-000408	Esophageal Cancer	p.E815D (No)	CCLE	PF2341066	8
ACH-000978	Endometrial/Uterine Cancer	p.G843R (No)	CCLE	PHA-665752	8
ACH-000978	Endometrial/Uterine Cancer	p.G843R (No)	CCLE	PF2341066	8
ACH-000921	Lung Cancer	p.I852F (No)	CCLE	PHA-665752	8
ACH-000921	Lung Cancer	p.I852F (No)	CCLE	PF2341066	8
ACH-000876	Breast Cancer	p.D946H (No)	CCLE	PHA-665752	8
ACH-000876	Breast Cancer	p.D946H (No)	CCLE	PF2341066	8
ACH-000973	Bladder Cancer	p.L967F (No)	CCLE	PHA-665752	8
ACH-000973	Bladder Cancer	p.L967F (No)	CCLE	PF2341066	5.6625
ACH-000988	Endometrial/Uterine Cancer	p.K980K (No)	CCLE	PHA-665752	8
ACH-000988	Endometrial/Uterine Cancer	p.K980K (No)	CCLE	PF2341066	8
ACH-000894	Lung Cancer	p.Y989C (No)	CCLE	PHA-665752	8
ACH-000894	Lung Cancer	p.Y989C (No)	CCLE	PF2341066	8
ACH-000847	Gastric Cancer	p.Y989* (No)	CCLE	PHA-665752	8
ACH-000847	Gastric Cancer	p.Y989* (No)	CCLE	PF2341066	3.3069
ACH-000383	Esophageal Cancer	p.V1007I (No)	CCLE	PHA-665752	8
ACH-000383	Esophageal Cancer	p.V1007I (No)	CCLE	PF2341066	0.8948
ACH-000878	Lung Cancer	p.L1158F (No)	CCLE	PHA-665752	8
ACH-000878	Lung Cancer	p.L1158F (No)	CCLE	PF2341066	8
ACH-000967	Colon/Colorectal Cancer	p.R1166* (No)	CCLE	PHA-665752	8
ACH-000967	Colon/Colorectal Cancer	p.R1166* (No)	CCLE	PF2341066	8
ACH-001199	Colon/Colorectal Cancer	p.R1166* (No)	CCLE	PHA-665752	8
ACH-001199	Colon/Colorectal Cancer	p.R1166* (No)	CCLE	PF2341066	8
ACH-000980	Lung Cancer	p.L1230L (No)	CCLE	PHA-665752	8
ACH-000980	Lung Cancer	p.L1230L (No)	CCLE	PF2341066	2.5806
ACH-000889	Myeloma	p.D1240N (No)	CCLE	PHA-665752	0.7209
ACH-000889	Myeloma	p.D1240N (No)	CCLE	PF2341066	3.7147
ACH-000995	Leukemia	p.D1328fs (No)	CCLE	PHA-665752	4.2212
ACH-000995	Leukemia	p.D1328fs (No)	CCLE	PF2341066	1.6869
ACH-000851	Lung Cancer	p.A1357V (No)	CCLE	PHA-665752	8
ACH-000851	Lung Cancer	p.A1357V (No)	CCLE	PF2341066	8
ACH-000954	Endometrial/Uterine Cancer	p.V1368D (No)	CCLE	PHA-665752	8
ACH-000954	Endometrial/Uterine Cancer	p.V1368D (No)	CCLE	PF2341066	8
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	PHA-665752	17.2441
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	Crizotinib	7.6781
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	Cabozantinib	4.4868
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	JNJ38877605	169.2053
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	SU11274	6.9338
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	Foretinib	0.3712
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	AZD6094	6.7751
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	Crizotinib	6.5122
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	Savolitinib	1.191
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	Foretinib	4.5486
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	PHA-665752	43.8301
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	Crizotinib	17.4096
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	Cabozantinib	57.8143
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	JNJ38877605	82.0185
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	SU11274	50.4066
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	Foretinib	3.9915
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	AZD6094	43.896
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	Crizotinib	34.001
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	Savolitinib	84.671
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	Foretinib	10.275
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	Cabozantinib	7.227
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	JNJ38877605	151.0574
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	SU11274	19.8908
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	Foretinib	0.3838
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	AZD6094	14.2737
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	Crizotinib	2.3355
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	Savolitinib	8.7656
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	Foretinib	1.7066
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	Cabozantinib	54.0325
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	JNJ38877605	81.898
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	SU11274	77.1018
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	Foretinib	4.3302
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	AZD6094	23.4378
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	Crizotinib	136.77
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	Savolitinib	10.24
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	Foretinib	45.124
SIDM00534	COREAD\|large_intestine	p.R1188* (No)	GDSC	Cabozantinib	34.719
SIDM00534	COREAD\|large_intestine	p.R1188* (No)	GDSC	JNJ38877605	98.2251
SIDM00534	COREAD\|large_intestine	p.R1188* (No)	GDSC	SU11274	24.7074
SIDM00534	COREAD\|large_intestine	p.R1188* (No)	GDSC	Foretinib	4.5289
SIDM00534	COREAD\|large_intestine	p.R1188* (No)	GDSC	AZD6094	29.3711
SIDM00534	COREAD\|large_intestine	p.R1188* (No)	GDSC	Crizotinib	3.2086
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	Cabozantinib	5.3227
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	JNJ38877605	97.274
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	SU11274	41.8516
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	Foretinib	0.3147
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	AZD6094	9.6424
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	Crizotinib	25.914
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	Savolitinib	3.1951
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	Foretinib	0.8175
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	PHA-665752	18.2154
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	Crizotinib	8.5771
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	Cabozantinib	3.9297
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	JNJ38877605	162.9635
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	SU11274	85.6621
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	Foretinib	0.1434
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	AZD6094	15.3475
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	Crizotinib	12.867
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	Savolitinib	5.0299
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	Foretinib	0.7641
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	PHA-665752	12.3737
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	Crizotinib	9.1451
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	Cabozantinib	4.964
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	JNJ38877605	42.4686
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	SU11274	7.8059
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	Foretinib	0.724
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	AZD6094	8.0594
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	Crizotinib	1.3568
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	Savolitinib	3.4106
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	Foretinib	2.773
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	Cabozantinib	6.895
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	JNJ38877605	26.4521
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	SU11274	30.3242
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	Foretinib	0.2756
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	AZD6094	18.9843
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	Crizotinib	38.845
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	Savolitinib	18.894
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	Foretinib	0.7175
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	Cabozantinib	10.0937
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	JNJ38877605	14.6691
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	SU11274	150.8069
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	Foretinib	1.1163
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	AZD6094	41.521
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	Crizotinib	9.505
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	Savolitinib	16.428
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	Foretinib	6.3346
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	Cabozantinib	100.7682
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	JNJ38877605	194.7582
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	SU11274	102.5621
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	Foretinib	23.5981
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	AZD6094	43.5956
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	Crizotinib	106.09
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	Savolitinib	15.218
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	Foretinib	2.6383
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	Cabozantinib	3.8227
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	JNJ38877605	197.2173
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	SU11274	9.0882
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	Foretinib	0.3922
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	AZD6094	21.3644
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	Crizotinib	46.901
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	Savolitinib	21.387
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	Foretinib	3.3402
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	Cabozantinib	3.8227
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	JNJ38877605	197.2173
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	SU11274	9.0882
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	Foretinib	0.3922
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	AZD6094	21.3644
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	Crizotinib	46.901
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	Savolitinib	21.387
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	Foretinib	3.3402
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	Cabozantinib	3.8227
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	JNJ38877605	197.2173
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	SU11274	9.0882
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	Foretinib	0.3922
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	AZD6094	21.3644
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	Crizotinib	46.901
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	Savolitinib	21.387
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	Foretinib	3.3402
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	PHA-665752	31.5811
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	Crizotinib	30.7228
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	Cabozantinib	13.5506
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	JNJ38877605	230.8433
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	SU11274	22.421
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	Foretinib	1.5327
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	AZD6094	35.5626
SIDM01164	LGG\|glioma	p.T1010I (No)	GDSC	Cabozantinib	14.4553
SIDM01164	LGG\|glioma	p.T1010I (No)	GDSC	JNJ38877605	40.9317
SIDM01164	LGG\|glioma	p.T1010I (No)	GDSC	SU11274	12.0738
SIDM01164	LGG\|glioma	p.T1010I (No)	GDSC	Foretinib	0.7951
SIDM01164	LGG\|glioma	p.T1010I (No)	GDSC	AZD6094	10.8726
SIDM01164	LGG\|glioma	p.T1010I (No)	GDSC	Savolitinib	16.793
SIDM01164	LGG\|glioma	p.T1010I (No)	GDSC	Foretinib	2.177
SIDM00325	ESCA\|oesophagus	p.V1007I (No)	GDSC	PHA-665752	30.7225
SIDM00325	ESCA\|oesophagus	p.V1007I (No)	GDSC	Crizotinib	29.6672
SIDM00325	ESCA\|oesophagus	p.V1007I (No)	GDSC	Cabozantinib	58.5084
SIDM00325	ESCA\|oesophagus	p.V1007I (No)	GDSC	JNJ38877605	82.6947
SIDM00325	ESCA\|oesophagus	p.V1007I (No)	GDSC	SU11274	51.9675
SIDM00325	ESCA\|oesophagus	p.V1007I (No)	GDSC	Foretinib	5.5256
SIDM00325	ESCA\|oesophagus	p.V1007I (No)	GDSC	AZD6094	7.3676
SIDM00325	ESCA\|oesophagus	p.V1007I (No)	GDSC	Crizotinib	29.866
SIDM00325	ESCA\|oesophagus	p.V1007I (No)	GDSC	Savolitinib	18.265
SIDM00325	ESCA\|oesophagus	p.V1007I (No)	GDSC	Foretinib	1.8367
SIDM00776	COREAD\|large_intestine	p.T1010I (No)	GDSC	PHA-665752	30.8511
SIDM00776	COREAD\|large_intestine	p.T1010I (No)	GDSC	Crizotinib	62.9203
SIDM00776	COREAD\|large_intestine	p.T1010I (No)	GDSC	Cabozantinib	19.4088
SIDM00776	COREAD\|large_intestine	p.T1010I (No)	GDSC	JNJ38877605	139.9312
SIDM00776	COREAD\|large_intestine	p.T1010I (No)	GDSC	SU11274	148.9845
SIDM00776	COREAD\|large_intestine	p.T1010I (No)	GDSC	Foretinib	5.5441
SIDM00776	COREAD\|large_intestine	p.T1010I (No)	GDSC	AZD6094	69.2874
SIDM00776	COREAD\|large_intestine	p.T1010I (No)	GDSC	Crizotinib	11.092
SIDM00776	COREAD\|large_intestine	p.T1010I (No)	GDSC	Savolitinib	69.952
SIDM00776	COREAD\|large_intestine	p.T1010I (No)	GDSC	Foretinib	4.6565
SIDM00941	KIRC\|kidney	p.V1238I (No)	GDSC	Cabozantinib	14.2225
SIDM00941	KIRC\|kidney	p.V1238I (No)	GDSC	JNJ38877605	26.2341
SIDM00941	KIRC\|kidney	p.V1238I (No)	GDSC	SU11274	50.0633
SIDM00941	KIRC\|kidney	p.V1238I (No)	GDSC	Foretinib	0.4501
SIDM00941	KIRC\|kidney	p.V1238I (No)	GDSC	AZD6094	36.6842
SIDM00678	BLCA\|bladder	p.T1010I (No)	GDSC	Cabozantinib	112.6655
SIDM00678	BLCA\|bladder	p.T1010I (No)	GDSC	JNJ38877605	53.7581
SIDM00678	BLCA\|bladder	p.T1010I (No)	GDSC	SU11274	108.8966
SIDM00678	BLCA\|bladder	p.T1010I (No)	GDSC	Foretinib	112.701
SIDM00678	BLCA\|bladder	p.T1010I (No)	GDSC	AZD6094	40.7749
SIDM00678	BLCA\|bladder	p.T1010I (No)	GDSC	Crizotinib	172.82
SIDM00678	BLCA\|bladder	p.T1010I (No)	GDSC	Savolitinib	91.158
SIDM00678	BLCA\|bladder	p.T1010I (No)	GDSC	Foretinib	17.139
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	Cabozantinib	13.4877
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	JNJ38877605	62.4457
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	SU11274	53.9688
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	Foretinib	1.2467
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	AZD6094	15.9232
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	Crizotinib	2.4905
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	Savolitinib	15.272
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	Foretinib	0.8531
SIDM01184	BLCA\|bladder	p.T1010I (No)	GDSC	Cabozantinib	22.2417
SIDM01184	BLCA\|bladder	p.T1010I (No)	GDSC	JNJ38877605	38.6669
SIDM01184	BLCA\|bladder	p.T1010I (No)	GDSC	SU11274	63.5032
SIDM01184	BLCA\|bladder	p.T1010I (No)	GDSC	Foretinib	2.6857
SIDM01184	BLCA\|bladder	p.T1010I (No)	GDSC	AZD6094	31.0364
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (No)	GDSC	PHA-665752	5.3858
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (No)	GDSC	Cabozantinib	10.4373
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (No)	GDSC	JNJ38877605	66.0368
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (No)	GDSC	SU11274	4.8221
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (No)	GDSC	Foretinib	0.3157
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (No)	GDSC	AZD6094	11.7421
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (No)	GDSC	Crizotinib	8.707
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (No)	GDSC	Savolitinib	8.9828
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (No)	GDSC	Foretinib	0.7013
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	PHA-665752	13.2447
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	Crizotinib	1.8356
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	Cabozantinib	10.7335
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	JNJ38877605	31.5874
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	SU11274	3.4637
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	Foretinib	0.9615
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	AZD6094	13.4189
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (No)	GDSC	PHA-665752	5.717
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (No)	GDSC	Crizotinib	1.648
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (No)	GDSC	Cabozantinib	2.6324
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (No)	GDSC	JNJ38877605	49.9928
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (No)	GDSC	SU11274	4.0892
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (No)	GDSC	Foretinib	0.2939
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (No)	GDSC	AZD6094	9.3463
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (No)	GDSC	Crizotinib	1.1106
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (No)	GDSC	Savolitinib	8.1805
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (No)	GDSC	Foretinib	0.3906
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	PHA-665752	14.9238
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	Crizotinib	22.2565
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	Cabozantinib	9.9083
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	JNJ38877605	40.747
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	SU11274	25.6952
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	Foretinib	5.9943
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	AZD6094	35.4035
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	Crizotinib	10.13
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	Savolitinib	23.513
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	Foretinib	4.473
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	PHA-665752	14.9238
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	Crizotinib	22.2565
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	Cabozantinib	9.9083
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	JNJ38877605	40.747
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	SU11274	25.6952
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	Foretinib	5.9943
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	AZD6094	35.4035
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	Crizotinib	10.13
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	Savolitinib	23.513
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	Foretinib	4.473
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	Cabozantinib	23.9587
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	JNJ38877605	146.6178
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	SU11274	206.1226
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	Foretinib	7.7813
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	AZD6094	27.235
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	Crizotinib	90.38
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	Savolitinib	22.229
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	Foretinib	3.2236
SIDM00108	SKCM\|melanoma	p.T1010I (No)	GDSC	PHA-665752	33.8385
SIDM00108	SKCM\|melanoma	p.T1010I (No)	GDSC	Crizotinib	17.4477
SIDM00108	SKCM\|melanoma	p.T1010I (No)	GDSC	Cabozantinib	12.2021
SIDM00108	SKCM\|melanoma	p.T1010I (No)	GDSC	JNJ38877605	160.9246
SIDM00108	SKCM\|melanoma	p.T1010I (No)	GDSC	SU11274	12.0386
SIDM00108	SKCM\|melanoma	p.T1010I (No)	GDSC	Foretinib	1.7957
SIDM00108	SKCM\|melanoma	p.T1010I (No)	GDSC	AZD6094	27.6886
SIDM00108	SKCM\|melanoma	p.T1010I (No)	GDSC	Crizotinib	103.35
SIDM00108	SKCM\|melanoma	p.T1010I (No)	GDSC	Savolitinib	25.21
SIDM00108	SKCM\|melanoma	p.T1010I (No)	GDSC	Foretinib	4.0544
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	Cabozantinib	5.4885
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	JNJ38877605	27.9558
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	SU11274	6.4413
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	Foretinib	0.5248
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	AZD6094	19.8039
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	Crizotinib	20.782
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	Savolitinib	22.481
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	Foretinib	0.5609
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	PHA-665752	22.0483
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	Crizotinib	34.0171
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	Cabozantinib	1.1593
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	JNJ38877605	49.3913
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	SU11274	9.7661
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	Foretinib	0.1594
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	AZD6094	45.7361
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	Crizotinib	48.406
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	Savolitinib	70.222
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	Foretinib	1.5884
SIDM00881	BRCA\|breast	p.T1010I (No)	GDSC	Cabozantinib	77.3759
SIDM00881	BRCA\|breast	p.T1010I (No)	GDSC	JNJ38877605	28.0349
SIDM00881	BRCA\|breast	p.T1010I (No)	GDSC	SU11274	92.3357
SIDM00881	BRCA\|breast	p.T1010I (No)	GDSC	Foretinib	72.3378
SIDM00881	BRCA\|breast	p.T1010I (No)	GDSC	AZD6094	29.1578
SIDM00881	BRCA\|breast	p.T1010I (No)	GDSC	Crizotinib	22.919
SIDM00881	BRCA\|breast	p.T1010I (No)	GDSC	Savolitinib	32.639
SIDM00881	BRCA\|breast	p.T1010I (No)	GDSC	Foretinib	9.4038
SIDM00777	COREAD\|large_intestine	p.R976T (No)	GDSC	AZD6094	43.2237
SIDM00777	COREAD\|large_intestine	p.R976T (No)	GDSC	Crizotinib	3.9975
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	PHA-665752	3.8571
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	Crizotinib	2.6015
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	Cabozantinib	1.7755
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	JNJ38877605	64.4981
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	SU11274	6.7043
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	Foretinib	0.1908
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	AZD6094	21.1495
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	Crizotinib	0.8455
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	Savolitinib	4.1817
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	Foretinib	0.4275
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	PHA-665752	3.8571
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	Crizotinib	2.6015
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	Cabozantinib	1.7755
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	JNJ38877605	64.4981
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	SU11274	6.7043
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	Foretinib	0.1908
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	AZD6094	21.1495
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	Crizotinib	0.8455
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	Savolitinib	4.1817
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	Foretinib	0.4275
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	Cabozantinib	78.0231
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	JNJ38877605	298.4791
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	SU11274	211.4888
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	Foretinib	32.5213
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	AZD6094	44.6788
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	Crizotinib	464.21
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	Savolitinib	18.626
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	Foretinib	203.12
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	PHA-665752	11.7428
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	Crizotinib	11.1196
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	Cabozantinib	12.9864
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	JNJ38877605	31.5974
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	SU11274	5.6099
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	Foretinib	1.6641
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	AZD6094	15.8003
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	Crizotinib	0.6377
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	Savolitinib	9.7025
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	Foretinib	0.0759
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	PHA-665752	32.616
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	Crizotinib	29.5319
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	Cabozantinib	7.9513
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	JNJ38877605	13.9418
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	SU11274	10.2713
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	Foretinib	0.5412
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	AZD6094	16.4311
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	Crizotinib	58.325
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	Savolitinib	26.475
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	Foretinib	1.3723
SIDM00801	SKCM\|melanoma	p.T1010I (No)	GDSC	PHA-665752	7.1466
SIDM00801	SKCM\|melanoma	p.T1010I (No)	GDSC	Crizotinib	15.8732
SIDM00801	SKCM\|melanoma	p.T1010I (No)	GDSC	Cabozantinib	10.286
SIDM00801	SKCM\|melanoma	p.T1010I (No)	GDSC	JNJ38877605	142.1628
SIDM00801	SKCM\|melanoma	p.T1010I (No)	GDSC	SU11274	14.7813
SIDM00801	SKCM\|melanoma	p.T1010I (No)	GDSC	Foretinib	0.956
SIDM00801	SKCM\|melanoma	p.T1010I (No)	GDSC	AZD6094	30.3869
SIDM00801	SKCM\|melanoma	p.T1010I (No)	GDSC	Crizotinib	11.084
SIDM00801	SKCM\|melanoma	p.T1010I (No)	GDSC	Savolitinib	10.362
SIDM00801	SKCM\|melanoma	p.T1010I (No)	GDSC	Foretinib	1.4889
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	PHA-665752	22.4917
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Crizotinib	16.942
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Cabozantinib	57.5912
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	JNJ38877605	198.0691
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	SU11274	49.1089
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Foretinib	1.7568
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	AZD6094	25.9014
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Crizotinib	53.466
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Savolitinib	10.767
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Foretinib	10.54
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	PHA-665752	28.1191
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	Crizotinib	19.8777
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	Cabozantinib	9.8171
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	JNJ38877605	66.1107
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	SU11274	74.043
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	Foretinib	0.816
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	AZD6094	36.7306
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	Crizotinib	2.7835
SIDM00318	KIRC\|kidney	p.N375S (No)	GDSC	Cabozantinib	8.0025
SIDM00318	KIRC\|kidney	p.N375S (No)	GDSC	JNJ38877605	21.4235
SIDM00318	KIRC\|kidney	p.N375S (No)	GDSC	SU11274	24.9994
SIDM00318	KIRC\|kidney	p.N375S (No)	GDSC	Foretinib	1.1465
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	Cabozantinib	16.8316
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	JNJ38877605	162.1547
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	SU11274	64.2366
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	Foretinib	0.6811
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	AZD6094	39.7902
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	Crizotinib	2.7793
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	Savolitinib	5.2346
SIDM00003	SKCM\|melanoma	p.M1I (Yes)	GDSC	Cabozantinib	5.8082
SIDM00003	SKCM\|melanoma	p.M1I (Yes)	GDSC	JNJ38877605	259.6267
SIDM00003	SKCM\|melanoma	p.M1I (Yes)	GDSC	SU11274	177.9896
SIDM00003	SKCM\|melanoma	p.M1I (Yes)	GDSC	Foretinib	0.4439
SIDM00003	SKCM\|melanoma	p.M1I (Yes)	GDSC	AZD6094	53.6459
SIDM00003	SKCM\|melanoma	p.M1I (Yes)	GDSC	Crizotinib	49.795
SIDM00003	SKCM\|melanoma	p.M1I (Yes)	GDSC	Savolitinib	9.108
SIDM00003	SKCM\|melanoma	p.M1I (Yes)	GDSC	Foretinib	1.6566
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	Cabozantinib	16.6294
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	JNJ38877605	148.1743
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	SU11274	36.1074
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	Foretinib	0.9419
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	Crizotinib	10.471
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	Savolitinib	12.412
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	Foretinib	1.6407
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	PHA-665752	12.1954
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	Crizotinib	0.3868
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	Cabozantinib	4.9456
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	JNJ38877605	73.9387
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	SU11274	16.2419
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	Foretinib	0.3863
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	AZD6094	7.9777
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	Crizotinib	0.1693
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	Savolitinib	1.8082
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	Foretinib	0.4679
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	Cabozantinib	109.5301
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	JNJ38877605	226.1958
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	SU11274	222.6518
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	Foretinib	111.3259
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	AZD6094	47.0009
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	Crizotinib	43.591
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	Savolitinib	14.657
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	Foretinib	1.7111
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	Cabozantinib	38.4248
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	JNJ38877605	179.6091
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	SU11274	47.5648
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	Foretinib	1.5909
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	AZD6094	23.8301
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	Crizotinib	6.9241
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	Savolitinib	20.744
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	Foretinib	4.9264
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	Cabozantinib	82.098
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	JNJ38877605	324.8044
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	SU11274	178.188
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	Foretinib	5.1482
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	AZD6094	27.0484
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	Crizotinib	214.83
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	Savolitinib	12.139
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	Foretinib	3.3855
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	PHA-665752	30.2231
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	Crizotinib	28.8129
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	Cabozantinib	77.2987
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	SU11274	6.9368
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	Foretinib	4.2043
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	AZD6094	23.343
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	Crizotinib	37.894
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	Savolitinib	39.891
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	Foretinib	31.522
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	Cabozantinib	50.7912
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	JNJ38877605	42.4935
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	SU11274	26.9316
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	Foretinib	16.2501
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	AZD6094	47.4777
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	Crizotinib	251.77
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	Foretinib	10.065
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	PHA-665752	17.0474
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	Crizotinib	10.5192
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	Cabozantinib	8.4382
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	JNJ38877605	63.077
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	SU11274	34.7571
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	Foretinib	0.619
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	AZD6094	23.578
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	Crizotinib	12.701
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	Savolitinib	6.0445
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	Foretinib	0.3825
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	Cabozantinib	11.3765
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	JNJ38877605	338.3443
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	SU11274	71.6667
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	Foretinib	1.0216
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	AZD6094	54.831
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	Crizotinib	24.898
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	Savolitinib	33.146
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	Foretinib	4.4671
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (Yes)	GDSC	PHA-665752	66.7199
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (Yes)	GDSC	Crizotinib	39.0913
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (Yes)	GDSC	Cabozantinib	140.6565
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (Yes)	GDSC	JNJ38877605	57.1259
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (Yes)	GDSC	SU11274	129.4371
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (Yes)	GDSC	Foretinib	9.2771
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (Yes)	GDSC	AZD6094	84.2403
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (Yes)	GDSC	Savolitinib	115.67
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (Yes)	GDSC	Foretinib	25.346
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	PHA-665752	66.7199
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	Crizotinib	39.0913
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	Cabozantinib	140.6565
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	JNJ38877605	57.1259
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	SU11274	129.4371
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	Foretinib	9.2771
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	AZD6094	84.2403
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	Savolitinib	115.67
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	Foretinib	25.346
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	PHA-665752	37.2134
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	Crizotinib	23.4821
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	Cabozantinib	40.6716
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	JNJ38877605	71.5203
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	SU11274	28.0086
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	Foretinib	18.5007
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	AZD6094	24.0576
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	Savolitinib	18.647
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	Foretinib	1.2106
SIDM00870	BRCA\|breast	p.D1198H (No)	GDSC	Cabozantinib	111.4519
SIDM00870	BRCA\|breast	p.D1198H (No)	GDSC	JNJ38877605	25.4352
SIDM00870	BRCA\|breast	p.D1198H (No)	GDSC	SU11274	12.1493
SIDM00870	BRCA\|breast	p.D1198H (No)	GDSC	Foretinib	5.9583
SIDM00870	BRCA\|breast	p.D1198H (No)	GDSC	AZD6094	12.7034
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	Cabozantinib	14.164
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	JNJ38877605	184.4401
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	SU11274	117.8841
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	Foretinib	1.1658
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	AZD6094	25.9244
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	Crizotinib	15.189
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	Savolitinib	25.601
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	Foretinib	8.6334
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	Cabozantinib	42.0625
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	JNJ38877605	89.2547
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	SU11274	113.1135
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	Foretinib	2.8306
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	AZD6094	19.3171
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	Crizotinib	2.7499
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	Savolitinib	3.9527
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	Foretinib	7.9407
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.N375S (No)	GDSC	Cabozantinib	58.3136
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.N375S (No)	GDSC	JNJ38877605	195.2903
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.N375S (No)	GDSC	SU11274	78.2183
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.N375S (No)	GDSC	Foretinib	5.6325
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.N375S (No)	GDSC	AZD6094	21.9083
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	PHA-665752	6.2352
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	Crizotinib	15.8698
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	Cabozantinib	6.7751
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	JNJ38877605	19.4157
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	SU11274	6.2926
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	Foretinib	1.6522
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	AZD6094	25.2341
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	Crizotinib	28.432
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	Foretinib	5.2938
SIDM00442	THCA\|thyroid	p.T1010I (No)	GDSC	Cabozantinib	10.0378
SIDM00442	THCA\|thyroid	p.T1010I (No)	GDSC	JNJ38877605	26.7074
SIDM00442	THCA\|thyroid	p.T1010I (No)	GDSC	SU11274	192.7118
SIDM00442	THCA\|thyroid	p.T1010I (No)	GDSC	Foretinib	1.8527
SIDM00442	THCA\|thyroid	p.T1010I (No)	GDSC	AZD6094	26.5519
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	Cabozantinib	127.0251
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	JNJ38877605	189.5152
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	SU11274	182.1535
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	Foretinib	145.5108
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	AZD6094	38.8082
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	Crizotinib	43.018
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	Savolitinib	14.374
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	Foretinib	3.8585
SIDM00507	UNCLASSIFIED\|lung_other	p.I583M (No)	GDSC	Cabozantinib	24.5353
SIDM00507	UNCLASSIFIED\|lung_other	p.I583M (No)	GDSC	JNJ38877605	94.9108
SIDM00507	UNCLASSIFIED\|lung_other	p.I583M (No)	GDSC	SU11274	15.3413
SIDM00507	UNCLASSIFIED\|lung_other	p.I583M (No)	GDSC	Foretinib	1.3018
SIDM00507	UNCLASSIFIED\|lung_other	p.I583M (No)	GDSC	AZD6094	26.1435
SIDM00217	COREAD\|large_intestine	p.V122D (No)	GDSC	Cabozantinib	12.0756
SIDM00217	COREAD\|large_intestine	p.V122D (No)	GDSC	JNJ38877605	33.9011
SIDM00217	COREAD\|large_intestine	p.V122D (No)	GDSC	SU11274	70.9644
SIDM00217	COREAD\|large_intestine	p.V122D (No)	GDSC	Foretinib	1.6723
SIDM00217	COREAD\|large_intestine	p.V122D (No)	GDSC	AZD6094	56.5171
SIDM00217	COREAD\|large_intestine	p.V122D (No)	GDSC	Crizotinib	8.8254
SIDM00217	COREAD\|large_intestine	p.N375S (No)	GDSC	Cabozantinib	12.0756
SIDM00217	COREAD\|large_intestine	p.N375S (No)	GDSC	JNJ38877605	33.9011
SIDM00217	COREAD\|large_intestine	p.N375S (No)	GDSC	SU11274	70.9644
SIDM00217	COREAD\|large_intestine	p.N375S (No)	GDSC	Foretinib	1.6723
SIDM00217	COREAD\|large_intestine	p.N375S (No)	GDSC	AZD6094	56.5171
SIDM00217	COREAD\|large_intestine	p.N375S (No)	GDSC	Crizotinib	8.8254
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	Cabozantinib	3.4852
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	JNJ38877605	32.3061
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	SU11274	67.4527
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	Foretinib	0.7064
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	AZD6094	8.1617
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	Crizotinib	5.7056
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	Savolitinib	6.0149
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	Foretinib	0.4891
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T1010I (No)	GDSC	Cabozantinib	101.0679
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T1010I (No)	GDSC	Foretinib	7.5112
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T1010I (No)	GDSC	AZD6094	15.5579
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T1010I (No)	GDSC	Crizotinib	22.117
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T1010I (No)	GDSC	Savolitinib	6.1202
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T1010I (No)	GDSC	Foretinib	2.6253
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Cabozantinib	7.2858
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	JNJ38877605	36.0032
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	SU11274	71.3557
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Foretinib	0.5822
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	AZD6094	12.7073
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Crizotinib	8.4343
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Savolitinib	6.0251
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Foretinib	31.947
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	PHA-665752	7.7418
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	Crizotinib	3.5629
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	Cabozantinib	3.6448
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	JNJ38877605	57.338
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	SU11274	3.8614
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	Foretinib	0.3998
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	AZD6094	5.2708
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	Savolitinib	8.063
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	Foretinib	0.3051
SIDM00050	UNCLASSIFIED\|chondrosarcoma	p.V1289M (No)	GDSC	Cabozantinib	3.2848
SIDM00050	UNCLASSIFIED\|chondrosarcoma	p.V1289M (No)	GDSC	Foretinib	0.8433
SIDM00050	UNCLASSIFIED\|chondrosarcoma	p.V1289M (No)	GDSC	AZD6094	8.3461
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	Cabozantinib	18.8532
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	JNJ38877605	50.6133
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	SU11274	91.9794
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	Foretinib	2.3784
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	AZD6094	20.9362
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	Crizotinib	94.019
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	Savolitinib	19.453
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	Foretinib	1.868
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	PHA-665752	29.2168
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	Crizotinib	32.5729
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	Cabozantinib	54.3496
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	JNJ38877605	52.4957
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	SU11274	110.6518
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	Foretinib	3.4158
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	AZD6094	23.6941
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	Crizotinib	99.015
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	Savolitinib	22.834
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	Foretinib	6.636
SIDM00477	ESCA\|oesophagus	p.V1007I (No)	GDSC	Cabozantinib	1.5311
SIDM00477	ESCA\|oesophagus	p.V1007I (No)	GDSC	JNJ38877605	9.1087
SIDM00477	ESCA\|oesophagus	p.V1007I (No)	GDSC	SU11274	34.397
SIDM00477	ESCA\|oesophagus	p.V1007I (No)	GDSC	Foretinib	0.2771
SIDM00477	ESCA\|oesophagus	p.V1007I (No)	GDSC	AZD6094	3.5895
SIDM00477	ESCA\|oesophagus	p.V1007I (No)	GDSC	Crizotinib	1.8787
SIDM00477	ESCA\|oesophagus	p.V1007I (No)	GDSC	Savolitinib	3.3732
SIDM00477	ESCA\|oesophagus	p.V1007I (No)	GDSC	Foretinib	0.6008
SIDM00479	ESCA\|oesophagus	p.K6N (Yes)	GDSC	Cabozantinib	100.1288
SIDM00479	ESCA\|oesophagus	p.K6N (Yes)	GDSC	JNJ38877605	39.5869
SIDM00479	ESCA\|oesophagus	p.K6N (Yes)	GDSC	SU11274	25.2141
SIDM00479	ESCA\|oesophagus	p.K6N (Yes)	GDSC	Foretinib	6.6399
SIDM00479	ESCA\|oesophagus	p.K6N (Yes)	GDSC	AZD6094	59.7521
SIDM00479	ESCA\|oesophagus	p.K6N (Yes)	GDSC	Crizotinib	18.627
SIDM00479	ESCA\|oesophagus	p.K6N (Yes)	GDSC	Savolitinib	20.715
SIDM00479	ESCA\|oesophagus	p.K6N (Yes)	GDSC	Foretinib	1.9328
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	Cabozantinib	3.0756
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	JNJ38877605	32.4827
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	SU11274	19.7909
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	Foretinib	0.1601
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	AZD6094	5.6118
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	Crizotinib	5.7417
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	Savolitinib	1.6239
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	Foretinib	0.8172
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	PHA-665752	6.0873
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	Crizotinib	3.5811
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	Cabozantinib	7.1762
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	JNJ38877605	61.4805
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	SU11274	21.1492
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	Foretinib	0.9388
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	AZD6094	5.2233
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	PHA-665752	18.1781
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	Crizotinib	4.2088
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	Cabozantinib	13.9018
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	JNJ38877605	316.0609
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	SU11274	86.1406
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	Foretinib	0.8652
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	AZD6094	40.6797
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	Crizotinib	5.0632
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	Savolitinib	28.266
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	Foretinib	1.4128
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	Cabozantinib	4.05
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	JNJ38877605	59.4448
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	SU11274	25.2081
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	Foretinib	0.2489
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	AZD6094	22.804
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	Crizotinib	10.725
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	Savolitinib	2.9304
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	Foretinib	0.6207
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N375S (No)	GDSC	PHA-665752	22.6657
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N375S (No)	GDSC	Crizotinib	19.9725
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N375S (No)	GDSC	Cabozantinib	36.5642
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N375S (No)	GDSC	JNJ38877605	79.4232
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N375S (No)	GDSC	SU11274	67.0028
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N375S (No)	GDSC	Foretinib	2.343
SIDM01000	SKCM\|melanoma	p.T1010I (No)	GDSC	Cabozantinib	10.1738
SIDM01000	SKCM\|melanoma	p.T1010I (No)	GDSC	JNJ38877605	39.7508
SIDM01000	SKCM\|melanoma	p.T1010I (No)	GDSC	SU11274	101.5713
SIDM01000	SKCM\|melanoma	p.T1010I (No)	GDSC	Foretinib	0.856
SIDM01000	SKCM\|melanoma	p.T1010I (No)	GDSC	AZD6094	37.4808
SIDM01000	SKCM\|melanoma	p.T1010I (No)	GDSC	Crizotinib	52.316
SIDM01000	SKCM\|melanoma	p.T1010I (No)	GDSC	Savolitinib	11.296
SIDM01000	SKCM\|melanoma	p.T1010I (No)	GDSC	Foretinib	4.7606
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	Cabozantinib	7.3368
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	JNJ38877605	15.0119
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	SU11274	7.0805
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	Foretinib	0.7116
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	AZD6094	27.7991
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	Crizotinib	41.568
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	Savolitinib	37.189
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	Foretinib	3.0162
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	Cabozantinib	23.4835
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	JNJ38877605	357.5145
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	SU11274	183.0642
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	Foretinib	2.052
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	AZD6094	16.3362
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	Crizotinib	129.11
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	Savolitinib	26.868
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	Foretinib	11.505
SIDM00557	NB\|neuroblastoma	p.N375S (No)	GDSC	PHA-665752	26.7249
SIDM00557	NB\|neuroblastoma	p.N375S (No)	GDSC	Crizotinib	1.3516
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (No)	GDSC	PHA-665752	18.0768
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (No)	GDSC	Crizotinib	17.1487
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (No)	GDSC	Cabozantinib	14.6269
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (No)	GDSC	JNJ38877605	183.4968
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (No)	GDSC	SU11274	93.1072
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (No)	GDSC	Foretinib	3.8073
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (No)	GDSC	AZD6094	21.2787
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (No)	GDSC	Crizotinib	5.464
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (No)	GDSC	Savolitinib	7.8757
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (No)	GDSC	Foretinib	2.3693
SIDM00279	UNCLASSIFIED\|stomach	p.P1009S (No)	GDSC	Crizotinib	56.106
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	PHA-665752	9.5729
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	Crizotinib	6.3021
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	Cabozantinib	12.0551
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	JNJ38877605	40.6479
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	SU11274	4.6568
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	Foretinib	0.6156
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	AZD6094	11.3641
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	Crizotinib	9.1778
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	Savolitinib	6.8091
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	Foretinib	3.6308
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	Cabozantinib	52.3382
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	JNJ38877605	30.058
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	SU11274	69.2075
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	Foretinib	3.3984
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	AZD6094	59.5529
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	Crizotinib	120.8
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	Savolitinib	5.5655
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	Foretinib	3.6788
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	PHA-665752	12.0743
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	Crizotinib	20.0046
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	Cabozantinib	0.7727
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	JNJ38877605	21.7174
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	SU11274	4.9883
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	Foretinib	0.0623
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	AZD6094	14.3024
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	Crizotinib	19.514
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	Savolitinib	8.9698
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	Foretinib	0.6014
SIDM00819	KIRC\|kidney	p.V136I (No)	GDSC	Cabozantinib	18.0066
SIDM00819	KIRC\|kidney	p.V136I (No)	GDSC	JNJ38877605	14.5893
SIDM00819	KIRC\|kidney	p.V136I (No)	GDSC	SU11274	26.5801
SIDM00819	KIRC\|kidney	p.V136I (No)	GDSC	Foretinib	0.7353
SIDM00819	KIRC\|kidney	p.V136I (No)	GDSC	AZD6094	12.3475
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	Cabozantinib	67.7731
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	JNJ38877605	62.5579
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	SU11274	99.0035
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	Foretinib	2.1901
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	AZD6094	20.5453
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	Crizotinib	32.846
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	Savolitinib	10.205
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	Foretinib	2.1269
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	PHA-665752	6.6267
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	Crizotinib	3.3378
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	Cabozantinib	11.4291
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	JNJ38877605	39.4066
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	SU11274	11.1359
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	Foretinib	0.8607
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	AZD6094	17.0627
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	Crizotinib	8.1159
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	Savolitinib	6.3461
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	Foretinib	2.3568
SIDM00534	COREAD\|large_intestine	p.L455I (No)	GDSC	Cabozantinib	34.719
SIDM00534	COREAD\|large_intestine	p.L455I (No)	GDSC	JNJ38877605	98.2251
SIDM00534	COREAD\|large_intestine	p.L455I (No)	GDSC	SU11274	24.7074
SIDM00534	COREAD\|large_intestine	p.L455I (No)	GDSC	Foretinib	4.5289
SIDM00534	COREAD\|large_intestine	p.L455I (No)	GDSC	AZD6094	29.3711
SIDM00534	COREAD\|large_intestine	p.L455I (No)	GDSC	Crizotinib	3.2086
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	PHA-665752	76.7299
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	Crizotinib	80.6222
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	Cabozantinib	215.4655
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	JNJ38877605	33.1884
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	SU11274	66.4945
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	Foretinib	215.4655
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	AZD6094	86.9171
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	Crizotinib	274.07
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	Savolitinib	90.995
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	Foretinib	6.4082
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	Cabozantinib	3.8426
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	JNJ38877605	89.3803
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	SU11274	11.553
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	Foretinib	0.2985
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	AZD6094	20.6311
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	Crizotinib	253.4
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	Savolitinib	23.784
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	Foretinib	32.492
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	PHA-665752	27.0323
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	Crizotinib	18.617
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	Cabozantinib	46.7686
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	JNJ38877605	94.1225
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	SU11274	32.2586
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	Foretinib	1.7979
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	AZD6094	11.3871
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	Crizotinib	11.832
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	Savolitinib	1.9267
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	PHA-665752	21.0462
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	Crizotinib	10.0853
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	Cabozantinib	16.1575
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	JNJ38877605	47.0516
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	SU11274	28.598
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	Foretinib	0.5605
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	AZD6094	24.7541
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	Crizotinib	21.337
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	Savolitinib	8.8349
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	Foretinib	3.1113
SIDM01082	HNSC\|head_and_neck	p.N375S (No)	GDSC	Cabozantinib	3.2546
SIDM01082	HNSC\|head_and_neck	p.N375S (No)	GDSC	JNJ38877605	31.9893
SIDM01082	HNSC\|head_and_neck	p.N375S (No)	GDSC	SU11274	19.4659
SIDM01082	HNSC\|head_and_neck	p.N375S (No)	GDSC	Foretinib	0.2996
SIDM01082	HNSC\|head_and_neck	p.N375S (No)	GDSC	AZD6094	17.8393
SIDM01220	GBM\|glioma	p.R988C (No)	GDSC	Cabozantinib	14.0564
SIDM01220	GBM\|glioma	p.R988C (No)	GDSC	JNJ38877605	142.7773
SIDM01220	GBM\|glioma	p.R988C (No)	GDSC	SU11274	72.7507
SIDM01220	GBM\|glioma	p.R988C (No)	GDSC	Foretinib	1.7942
SIDM01220	GBM\|glioma	p.R988C (No)	GDSC	AZD6094	27.9689
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	PHA-665752	9.7647
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	Crizotinib	7.9656
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	Cabozantinib	3.557
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	JNJ38877605	102.8285
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	SU11274	16.593
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	Foretinib	0.3514
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	AZD6094	10.393
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	Crizotinib	15.905
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	Savolitinib	6.8906
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	Foretinib	0.3999
SIDM01087	SKCM\|melanoma	p.T17I (Yes)	GDSC	Cabozantinib	5.6829
SIDM01087	SKCM\|melanoma	p.T17I (Yes)	GDSC	JNJ38877605	30.0466
SIDM01087	SKCM\|melanoma	p.T17I (Yes)	GDSC	SU11274	7.176
SIDM01087	SKCM\|melanoma	p.T17I (Yes)	GDSC	Foretinib	0.4209
SIDM01087	SKCM\|melanoma	p.T17I (Yes)	GDSC	AZD6094	12.1427
SIDM01087	SKCM\|melanoma	p.T17I (Yes)	GDSC	Crizotinib	5.6649
SIDM01087	SKCM\|melanoma	p.T17I (Yes)	GDSC	Savolitinib	4.8904
SIDM01087	SKCM\|melanoma	p.T17I (Yes)	GDSC	Foretinib	1.8246
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	Cabozantinib	107.4008
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	JNJ38877605	382.0028
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	SU11274	210.3991
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	Foretinib	5.4278
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	AZD6094	35.6491
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	Savolitinib	39.008
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	Foretinib	4.0516
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	Cabozantinib	35.5871
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	JNJ38877605	17.5814
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	SU11274	69.9421
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	Foretinib	3.5226
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	AZD6094	36.7144
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	Savolitinib	24.893
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	Foretinib	3.3927
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	Cabozantinib	144.2481
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	JNJ38877605	104.5121
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	SU11274	101.4449
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	Foretinib	121.8592
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	AZD6094	33.2727
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	Crizotinib	199.25
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	Savolitinib	9.0022
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	Foretinib	29.013
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.D94G (No)	GDSC	Cabozantinib	47.1726
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.D94G (No)	GDSC	JNJ38877605	141.8334
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.D94G (No)	GDSC	SU11274	41.4572
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.D94G (No)	GDSC	Foretinib	1.4924
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	PHA-665752	36.0397
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	Crizotinib	9.3788
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	Cabozantinib	71.6314
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	JNJ38877605	29.858
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	SU11274	10.1539
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	Foretinib	5.6349
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	AZD6094	16.4806
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	Crizotinib	32.043
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	Savolitinib	9.7556
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	Foretinib	3.3809
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	PHA-665752	2.2141
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	Crizotinib	15.5121
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	Cabozantinib	9.417
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	JNJ38877605	71.4406
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	SU11274	11.1552
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	Foretinib	1.3415
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	AZD6094	9.5249
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	Crizotinib	11.279
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	Savolitinib	20.136
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	Foretinib	2.078
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (No)	GDSC	Cabozantinib	3.7646
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (No)	GDSC	JNJ38877605	20.6787
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (No)	GDSC	SU11274	21.5341
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (No)	GDSC	Foretinib	0.3739
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (No)	GDSC	AZD6094	18.5803
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (No)	GDSC	Crizotinib	11.734
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (No)	GDSC	Savolitinib	17.071
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (No)	GDSC	Foretinib	0.3083
SIDM00254	NB\|neuroblastoma	p.G24E (Yes)	GDSC	PHA-665752	30.2212
SIDM00254	NB\|neuroblastoma	p.G24E (Yes)	GDSC	Crizotinib	15.9336
SIDM00254	NB\|neuroblastoma	p.G24E (Yes)	GDSC	Cabozantinib	37.2902
SIDM00254	NB\|neuroblastoma	p.G24E (Yes)	GDSC	JNJ38877605	235.0803
SIDM00254	NB\|neuroblastoma	p.G24E (Yes)	GDSC	SU11274	120.327
SIDM00254	NB\|neuroblastoma	p.G24E (Yes)	GDSC	AZD6094	19.9005
SIDM01173	UNCLASSIFIED\|rhabdomyosarcoma	p.G24E (Yes)	GDSC	PHA-665752	1.8825
SIDM01173	UNCLASSIFIED\|rhabdomyosarcoma	p.G24E (Yes)	GDSC	Crizotinib	10.1604
SIDM01173	UNCLASSIFIED\|rhabdomyosarcoma	p.G24E (Yes)	GDSC	Cabozantinib	38.2563
SIDM01173	UNCLASSIFIED\|rhabdomyosarcoma	p.G24E (Yes)	GDSC	Foretinib	1.7401
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	Cabozantinib	52.2087
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	JNJ38877605	188.7186
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	SU11274	105.5962
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	Foretinib	2.3867
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	AZD6094	36.7036
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	Crizotinib	18.457
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	Savolitinib	18.399
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	Foretinib	1.3149
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	PHA-665752	36.2133
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	Crizotinib	49.2184
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	Cabozantinib	137.8718
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	JNJ38877605	83.3034
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	SU11274	232.19
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	Foretinib	8.3899
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	AZD6094	24.7663
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	Crizotinib	11.231
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	Savolitinib	66.08
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	Foretinib	23.473
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	Cabozantinib	15.8876
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	JNJ38877605	63.2654
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	SU11274	260.2295
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	Foretinib	0.596
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	AZD6094	38.4646
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	Crizotinib	53.34
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	Savolitinib	53.911
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	Foretinib	7.8612
SIDM00417	MM\|myeloma	p.T1010I (No)	GDSC	AZD6094	30.4855
SIDM00417	MM\|myeloma	p.T1010I (No)	GDSC	Crizotinib	37.401
SIDM00417	MM\|myeloma	p.T1010I (No)	GDSC	Savolitinib	18.397
SIDM00417	MM\|myeloma	p.T1010I (No)	GDSC	Foretinib	9.6513
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	PHA-665752	17.3727
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	Crizotinib	8.3654
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	Cabozantinib	15.4167
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	JNJ38877605	172.8538
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	SU11274	85.9048
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	Foretinib	1.2978
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	AZD6094	11.1653
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	Crizotinib	14.301
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	Savolitinib	4.9434
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	Foretinib	5.7157
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	Cabozantinib	3.1951
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	JNJ38877605	39.3897
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	SU11274	24.658
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	Foretinib	0.3922
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	AZD6094	9.2751
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	Savolitinib	18.861
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	Foretinib	11.253
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	PHA-665752	3.1427
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	Crizotinib	2.3909
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	Cabozantinib	5.6926
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	JNJ38877605	18.2483
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	SU11274	29.9131
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	Foretinib	1.0657
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	AZD6094	1.9661
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	Crizotinib	15.7
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	Savolitinib	5.4012
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	Foretinib	1.6438
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	PHA-665752	34.0749
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	Crizotinib	7.4123
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	Cabozantinib	19.1626
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	JNJ38877605	326.1554
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	SU11274	18.2882
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	Foretinib	0.5741
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	AZD6094	13.7037
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	Crizotinib	23.738
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	Savolitinib	14.003
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	Foretinib	1.8666
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	Cabozantinib	8.3183
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	JNJ38877605	37.7622
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	SU11274	18.9212
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	Foretinib	1.1726
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	AZD6094	22.4841
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	Crizotinib	2.7879
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	Savolitinib	6.5443
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	Foretinib	1.3073
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	PHA-665752	8.6507
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Crizotinib	0.883
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Cabozantinib	6.721
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	JNJ38877605	92.0916
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	SU11274	49.3636
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Foretinib	0.6384
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Crizotinib	0.2722
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Savolitinib	5.9323
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Foretinib	1.0903
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (No)	GDSC	PHA-665752	41.4596
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (No)	GDSC	Crizotinib	20.9555
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (No)	GDSC	Cabozantinib	41.8362
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (No)	GDSC	JNJ38877605	433.5842
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (No)	GDSC	SU11274	85.5915
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (No)	GDSC	Foretinib	1.9663
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (No)	GDSC	AZD6094	44.4746
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (No)	GDSC	Crizotinib	50.258
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (No)	GDSC	Savolitinib	27.384
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (No)	GDSC	Foretinib	9.8277
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.I638L (No)	GDSC	Cabozantinib	18.5354
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.I638L (No)	GDSC	JNJ38877605	263.8416
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.I638L (No)	GDSC	SU11274	136.6857
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.I638L (No)	GDSC	Foretinib	1.1805
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.I638L (No)	GDSC	AZD6094	39.9478
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.A204fs*3 (No)	GDSC	PHA-665752	20.6426
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.A204fs*3 (No)	GDSC	Crizotinib	13.6056
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.A204fs*3 (No)	GDSC	Cabozantinib	15.7624
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.A204fs*3 (No)	GDSC	JNJ38877605	36.8225
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.A204fs*3 (No)	GDSC	SU11274	8.6945
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.A204fs*3 (No)	GDSC	Foretinib	0.8967
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	Cabozantinib	12.8638
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	JNJ38877605	47.3554
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	SU11274	11.8309
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	Foretinib	1.8128
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	AZD6094	17.3754
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	Crizotinib	7.2885
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	Savolitinib	5.1376
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	Foretinib	3.0854
SIDM00123	KIRC\|kidney	p.T1010I (No)	GDSC	Cabozantinib	16.8038
SIDM00123	KIRC\|kidney	p.T1010I (No)	GDSC	JNJ38877605	17.7826
SIDM00123	KIRC\|kidney	p.T1010I (No)	GDSC	SU11274	14.4601
SIDM00123	KIRC\|kidney	p.T1010I (No)	GDSC	Foretinib	0.9296
SIDM00123	KIRC\|kidney	p.T1010I (No)	GDSC	AZD6094	28.2543
SIDM00123	KIRC\|kidney	p.T1010I (No)	GDSC	Crizotinib	34.545
SIDM00123	KIRC\|kidney	p.T1010I (No)	GDSC	Savolitinib	39.255
SIDM00123	KIRC\|kidney	p.T1010I (No)	GDSC	Foretinib	1.4616
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	PHA-665752	19.7585
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	Crizotinib	25.7678
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	Cabozantinib	74.4918
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	JNJ38877605	286.6712
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	SU11274	111.7196
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	Foretinib	3.7287
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	AZD6094	32.3451
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	Crizotinib	42.715
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	Savolitinib	9.2801
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	Foretinib	6.5524
SIDM00193	COREAD\|large_intestine	p.A320V (No)	GDSC	Cabozantinib	133.9123
SIDM00193	COREAD\|large_intestine	p.A320V (No)	GDSC	JNJ38877605	474.3958
SIDM00193	COREAD\|large_intestine	p.A320V (No)	GDSC	SU11274	262.6236
SIDM00193	COREAD\|large_intestine	p.A320V (No)	GDSC	Foretinib	7.8838
SIDM00193	COREAD\|large_intestine	p.A320V (No)	GDSC	AZD6094	55.1173
SIDM00193	COREAD\|large_intestine	p.A320V (No)	GDSC	Crizotinib	42.439
SIDM00193	COREAD\|large_intestine	p.R591W (No)	GDSC	Cabozantinib	133.9123
SIDM00193	COREAD\|large_intestine	p.R591W (No)	GDSC	JNJ38877605	474.3958
SIDM00193	COREAD\|large_intestine	p.R591W (No)	GDSC	SU11274	262.6236
SIDM00193	COREAD\|large_intestine	p.R591W (No)	GDSC	Foretinib	7.8838
SIDM00193	COREAD\|large_intestine	p.R591W (No)	GDSC	AZD6094	55.1173
SIDM00193	COREAD\|large_intestine	p.R591W (No)	GDSC	Crizotinib	42.439
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	Cabozantinib	28.7329
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	JNJ38877605	67.4695
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	SU11274	75.3894
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	Foretinib	3.6532
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	AZD6094	26.6431
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	Crizotinib	4.5563
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	Savolitinib	4.7435
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	Foretinib	4.088
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	Cabozantinib	28.7329
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	JNJ38877605	67.4695
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	SU11274	75.3894
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	Foretinib	3.6532
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	AZD6094	26.6431
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	Crizotinib	4.5563
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	Savolitinib	4.7435
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	Foretinib	4.088

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPGILVLLFTL

Degron related mutations and impact score

Drug responses associated with MET mutations

All proteins holding degron of LAPGILVLLFTL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08581	Hepatocyte growth factor receptor	DEG_ODPH_VHL_1	7:18	LAPGILVLLFTL	VHL	0.7514	More...