DegronMD - Q7Z699(SPRED1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R251Q	TCGA-2W-A8YY	CESC	TCGA	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.0833
p.R251Q	DO223732	CESC	ICGC	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.0833
p.Y261H	TCGA-B0-4815	KIRC	TCGA	DYR	CBL_MET	260:262	Mutation altering degron motif	0.7229
p.Y261H	DO18661	KIRC	ICGC	DYR	CBL_MET	260:262	Mutation altering degron motif	0.7229
p.R256C	TCGA-B5-A3FC	UCEC	TCGA	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.2222
p.R256C	DO41871	UCEC	ICGC	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.2222
p.R256C	SIDM00683	Prostate Carcinoma	GDSC	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.2222
p.R256C	ACH-000977	lymph node	CCLE	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.2222
p.R256C	LNCaP-Clone-FGC	prostate	COSMIC	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.2222
p.M266T	TCGA-BR-8360	STAD	TCGA	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.2222
p.M266T	DO47745	STAD	ICGC	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.2222
p.E219D	TCGA-BR-8591	STAD	TCGA	NRVPLKSIR	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1111
p.E219D	DO47973	STAD	ICGC	NRVPLKSIR	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1111
p.R257H	TCGA-DF-A2KN	UCEC	TCGA	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.25
p.R257H	DO223282	UCEC	ICGC	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.25
p.A259V	TCGA-EY-A215	UCEC	TCGA	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.3056
p.A259V	DO42665	UCEC	ICGC	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.3056
p.K268E	TCGA-OR-A5LB	ACC	TCGA	DYR	CBL_MET	260:262	Mutation substituting flanking lysine	0.2778
p.L223P	TCGA-WE-A8K4	SKCM	TCGA	NRVPLKSIR	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.2222
p.L223P	DO51281	SKCM	ICGC	NRVPLKSIR	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.2222
p.S238I	TCGA-X6-A7WA	SARC	TCGA	NRVPLKSIR	DEG_APCC_DBOX_1	227:235	Mutation blocking phosphorylation signal	0.6944
p.S238I	DO220312	SARC	ICGC	NRVPLKSIR	DEG_APCC_DBOX_1	227:235	Mutation blocking phosphorylation signal	0.6944
p.P230H	DO222492	COCA	ICGC	NRVPLKSIR	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.6583
p.Q226P	DO233885	GACA	ICGC	NRVPLKSIR	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.D260N	DO16999	KIRC	ICGC	DYR	CBL_MET	260:262	Mutation altering degron motif	0.6932
p.R256H	DO229480	LAML	ICGC	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.2222
p.R256H	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.2222
p.V229F	DO229035	LICA	ICGC	NRVPLKSIR	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.5957
p.S225P	SIDM00878	Breast Carcinoma	GDSC	NRVPLKSIR	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.2778
p.S225P	ACH-000930	Breast Cancer	CCLE	NRVPLKSIR	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.2778
p.S225P	HCC1569	breast	COSMIC	NRVPLKSIR	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.2778
p.R256P	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.2222
p.R256P	ACH-000917	Esophageal Cancer	CCLE	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.2222
p.R256P	TE-4	oesophagus	COSMIC	DYR	CBL_MET	260:262	Mutation rewiring degron network	0.2222

Kaplan plot for SPRED1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPRED1

UniProt ID: Q7Z699

Entrez ID: 161742

Protein name: Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPRED1 in