DegronMD

Uniprot ID: Q7Z699

Source protein: Sprouty-related, EVH1 domain-containing protein 1

Source gene: SPRED1

Class: DEG_APCC_DBOX_1

Location: 227:235

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5483

ASA_SCORE: 94.4556

COIL: 0.7558

CONS_SCORE: 0.4226

DSS_SCORE: 0.3514

HELIX: 0.0569

FCONS_SCORE: 1.105

RIG_SCORE: 0.7382

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E219D	TCGA-BR-8591	STAD	TCGA	NRVPLKSIR	DEG_APCC_DBOX_1	0.1111
p.E219D	DO47973	STAD	ICGC	NRVPLKSIR	DEG_APCC_DBOX_1	0.1111
p.L223P	TCGA-WE-A8K4	SKCM	TCGA	NRVPLKSIR	DEG_APCC_DBOX_1	0.2222
p.L223P	DO51281	SKCM	ICGC	NRVPLKSIR	DEG_APCC_DBOX_1	0.2222
p.S238I	TCGA-X6-A7WA	SARC	TCGA	NRVPLKSIR	DEG_APCC_DBOX_1	0.6944
p.S238I	DO220312	SARC	ICGC	NRVPLKSIR	DEG_APCC_DBOX_1	0.6944
p.P230H	DO222492	COCA	ICGC	NRVPLKSIR	DEG_APCC_DBOX_1	0.6583
p.Q226P	DO233885	GACA	ICGC	NRVPLKSIR	DEG_APCC_DBOX_1	0.3056
p.V229F	DO229035	LICA	ICGC	NRVPLKSIR	DEG_APCC_DBOX_1	0.5957
p.S225P	SIDM00878	Breast Carcinoma	GDSC	NRVPLKSIR	DEG_APCC_DBOX_1	0.2778
p.S225P	ACH-000930	Breast Cancer	CCLE	NRVPLKSIR	DEG_APCC_DBOX_1	0.2778
p.S225P	HCC1569	breast	COSMIC	NRVPLKSIR	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z699	Sprouty-related, EVH1 domain-containing protein 1	DEG_APCC_DBOX_1	227:235	NRVPLKSIR	APC,CDC20,FZR1	0.5483	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons