DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 12667:12671

E3 ligase: SPOP

DEGRON score: 0.9914

ASA_SCORE: 78.38

COIL: 0.9428

CONS_SCORE: 0

DSS_SCORE: 0.4008

HELIX: 0.014

FCONS_SCORE: 0

RIG_SCORE: 0.6978

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G12674E	TCGA-A6-2686	COAD	TCGA	VPTSS	DEG_SPOP_SBC_1	0.25
p.G12674E	DO7828	COAD	ICGC	VPTSS	DEG_SPOP_SBC_1	0.25
p.P12666H	TCGA-AA-3833	COAD	TCGA	VPTSS	DEG_SPOP_SBC_1	0.3056
p.P12666H	DO9796	COAD	ICGC	VPTSS	DEG_SPOP_SBC_1	0.3056
p.Y12657C	TCGA-AA-A01R	COAD	TCGA	VPTSS	DEG_SPOP_SBC_1	0.0556
p.Y12657C	DO7934	COAD	ICGC	VPTSS	DEG_SPOP_SBC_1	0.0556
p.S12670I	TCGA-DU-6392	LGG	TCGA	VPTSS	DEG_SPOP_SBC_1	0.7341
p.S12670I	DO22237	LGG	ICGC	VPTSS	DEG_SPOP_SBC_1	0.7341
p.P12666S	TCGA-FJ-A3ZE	BLCA	TCGA	VPTSS	DEG_SPOP_SBC_1	0.3056
p.P12666S	DO484	BLCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.3056
p.L12680F	SIDM00545	Melanoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.0833
p.L12680F	ACH-000987	Skin Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.0833
p.L12680F	Mewo	skin	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.0833
p.P12673S	SIDM00545	Melanoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.2778
p.P12673S	ACH-000987	Skin Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.2778
p.P12673S	Mewo	skin	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.2778
p.P12673L	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	0.2778
p.P12673L	ACH-001489	Lung Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.2778
p.P12673L	COR-L32	lung	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.2778
p.L12680R	ACH-000560	Gastric Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.0833
p.L12680R	ECC10	stomach	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.0833
p.S12670T	ACH-002261	Neuroblastoma	CCLE	VPTSS	DEG_SPOP_SBC_1	0.6005
p.S12670T	KP-N-YS	autonomic_ganglia	COSMIC	VPTSS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75038	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	DEG_SPOP_SBC_1	1022:1026	VPTSS	SPOP	0.7337	More...
O75604	Ubiquitin carboxyl-terminal hydrolase 2	DEG_SPOP_SBC_1	54:58	VPTSS	SPOP	0.9881	More...
O94850	Dendrin	DEG_SPOP_SBC_1	251:255	VPTSS	SPOP	0.9712	More...
P22307	Sterol carrier protein 2	DEG_SPOP_SBC_1	422:426	VPTSS	SPOP	0.6008	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	546:550	VPTSS	SPOP	0.9975	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2863:2867	VPTSS	SPOP	0.9646	More...
Q01973	Inactive tyrosine-protein kinase transmembrane receptor ROR1	DEG_SPOP_SBC_1	41:45	VPTSS	SPOP	0.8246	More...
Q02447	Transcription factor Sp3	DEG_SPOP_SBC_1	331:335	VPTSS	SPOP	0.9924	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	471:475	VPTSS	SPOP	0.9372	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12511:12515	VPTSS	SPOP	0.96	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12667:12671	VPTSS	SPOP	0.9914	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1602:1606	VPTSS	SPOP	0.9498	More...
P60413	Keratin-associated protein 10-12	DEG_SPOP_SBC_1	216:220	VPTSS	SPOP	0.7395	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	927:931	VPTSS	SPOP	0.8818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons