DegronMD - O75038(PLCH2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1134K	DO219754	CESC	ICGC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.0833
p.P1185S	DO8858	COAD	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation rewiring degron network	0.1944
p.R1191S	DO8754	COAD	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation altering degron motif	0.7427
p.R1032Q	DO234389	ESAD	ICGC	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.1667
p.M1141I	DO233260	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.2778
p.M1141I	DO220878	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.2778
p.M1141I	DO47712	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.2778
p.R1198W	DO233767	GACA	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation altering degron motif	0.8634
p.R1019K	DO11854	GBM	ICGC	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.25
p.R1133H	DO19913	KIRC	ICGC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.0556
p.E1033K	DO229505	LAML	ICGC	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.1389
p.R1191W	DO52193	LIHC	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation altering degron motif	0.8634
p.P1145L	DO220906	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation altering degron motif	0.7582
p.G1142R	DO50284	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.3056
p.L1206M	DO47623	SKCM	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation rewiring degron network	0.1111
p.H1149N	DO38075	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.2778
p.R1198Q	DO219468	SKCM	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation altering degron motif	0.7329
p.G1202D	DO43434	UCEC	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation rewiring degron network	0.2222
p.G1202D	DO42600	UCEC	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation rewiring degron network	0.2222
p.L1204I	DO43306	UCEC	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation rewiring degron network	0.1667
p.P1184S	SIDM01313	Colorectal Carcinoma	GDSC	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation rewiring degron network	0.1667
p.P1017L	SIDM00524	Small Cell Lung Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.1944
p.P1017L	SIDM00535	Chondrosarcoma	GDSC	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.1944
p.P1017L	SIDM00889	Cervical Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.1944
p.P1017L	SIDM00564	Ovarian Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.1944
p.P1017L	SIDM00357	Small Cell Lung Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.1944
p.P1017L	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.1944
p.P1017L	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.1944
p.P1017L	SIDM00243	Other Solid Cancers	GDSC	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.1944
p.S1150L	SIDM00086	Kidney Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.25
p.S1150L	ACH-002195	Kidney Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.25
p.S1150L	RXF393	kidney	COSMIC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.25
p.H1139R	SIDM00623	Other Blood Cancers	GDSC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.2222
p.H1139R	Mo-T	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.2222
p.S1148T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.3056
p.S1148T	ACH-000980	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.3056
p.S1148T	NCI-H1155	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.3056
p.R1030W	SIDM00505	Pancreatic Carcinoma	GDSC	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.2222
p.S1188L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation rewiring degron network	0.2778
p.S1188L	ACH-002222	Leukemia	CCLE	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation rewiring degron network	0.2778
p.S1188L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ARPDLPPVT	DEG_APCC_DBOX_1	1190:1198	Mutation rewiring degron network	0.2778
p.S1145Y	ACH-000959	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	1143:1147	Mutation altering degron motif	0.712
p.P1034T	ACH-001097	Lymphoma	CCLE	VPTSS	DEG_SPOP_SBC_1	1022:1026	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLCH2

UniProt ID: O75038

Entrez ID: 9651

Protein name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-2) (Phosphoinositide phospholipase C-like 4) (PLC-L4) (Phospholipase C-like protein 4) (Phospholipase C-eta-2) (PLC-eta2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLCH2 in