DegronMD

Uniprot ID: O75038

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

Source gene: PLCH2

Class: DEG_APCC_DBOX_1

Location: 1190:1198

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.963

ASA_SCORE: 85.0889

COIL: 0.9136

CONS_SCORE: 0.3523

DSS_SCORE: 0.7768

HELIX: 0.0387

FCONS_SCORE: 1.0361

RIG_SCORE: 0.5764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1185S	DO8858	COAD	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	0.1944
p.R1191S	DO8754	COAD	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	0.7427
p.R1198W	DO233767	GACA	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	0.8634
p.R1191W	DO52193	LIHC	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	0.8634
p.L1206M	DO47623	SKCM	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	0.1111
p.R1198Q	DO219468	SKCM	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	0.7329
p.G1202D	DO43434	UCEC	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	0.2222
p.G1202D	DO42600	UCEC	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	0.2222
p.L1204I	DO43306	UCEC	ICGC	ARPDLPPVT	DEG_APCC_DBOX_1	0.1667
p.P1184S	SIDM01313	Colorectal Carcinoma	GDSC	ARPDLPPVT	DEG_APCC_DBOX_1	0.1667
p.S1188L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ARPDLPPVT	DEG_APCC_DBOX_1	0.2778
p.S1188L	ACH-002222	Leukemia	CCLE	ARPDLPPVT	DEG_APCC_DBOX_1	0.2778
p.S1188L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ARPDLPPVT	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75038	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	DEG_APCC_DBOX_1	1190:1198	ARPDLPPVT	APC,CDC20,FZR1	0.963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons