DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 12511:12515

E3 ligase: SPOP

DEGRON score: 0.96

ASA_SCORE: 80.72

COIL: 0.947

CONS_SCORE: 0

DSS_SCORE: 0.5193

HELIX: 0.0152

FCONS_SCORE: 0

RIG_SCORE: 0.6379

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V12511M	TCGA-AG-3896	READ	TCGA	VPTSS	DEG_SPOP_SBC_1	0.7208
p.V12511M	DO37259	READ	ICGC	VPTSS	DEG_SPOP_SBC_1	0.7208
p.G12525E	TCGA-EB-A431	SKCM	TCGA	VPTSS	DEG_SPOP_SBC_1	0.0556
p.G12525E	DO37671	SKCM	ICGC	VPTSS	DEG_SPOP_SBC_1	0.0556
p.T12509A	TCGA-PK-A5HB	ACC	TCGA	VPTSS	DEG_SPOP_SBC_1	0.2778
p.S12514T	DO230334	COCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.7116
p.S12514T	DO229010	COCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.7116
p.S12514T	DO229016	COCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.7116
p.S12514T	DO229003	COCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.7116
p.S12514T	DO229005	COCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.7116
p.S12514T	DO228941	LICA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.7116
p.S12514T	DO228957	LICA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.7116
p.G12525A	DO229013	COCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.0556
p.D12523H	DO229013	COCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.D12523H	DO229005	COCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.D12523G	DO48194	ESCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.L12524P	DO218136	GACA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.0833
p.D12523N	DO229479	SKCA	ICGC	VPTSS	DEG_SPOP_SBC_1	0.1111
p.P12512L	ACH-001390	Breast Cancer	CCLE	VPTSS	DEG_SPOP_SBC_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75038	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	DEG_SPOP_SBC_1	1022:1026	VPTSS	SPOP	0.7337	More...
O75604	Ubiquitin carboxyl-terminal hydrolase 2	DEG_SPOP_SBC_1	54:58	VPTSS	SPOP	0.9881	More...
O94850	Dendrin	DEG_SPOP_SBC_1	251:255	VPTSS	SPOP	0.9712	More...
P22307	Sterol carrier protein 2	DEG_SPOP_SBC_1	422:426	VPTSS	SPOP	0.6008	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	546:550	VPTSS	SPOP	0.9975	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2863:2867	VPTSS	SPOP	0.9646	More...
Q01973	Inactive tyrosine-protein kinase transmembrane receptor ROR1	DEG_SPOP_SBC_1	41:45	VPTSS	SPOP	0.8246	More...
Q02447	Transcription factor Sp3	DEG_SPOP_SBC_1	331:335	VPTSS	SPOP	0.9924	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	471:475	VPTSS	SPOP	0.9372	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12511:12515	VPTSS	SPOP	0.96	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12667:12671	VPTSS	SPOP	0.9914	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1602:1606	VPTSS	SPOP	0.9498	More...
P60413	Keratin-associated protein 10-12	DEG_SPOP_SBC_1	216:220	VPTSS	SPOP	0.7395	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	927:931	VPTSS	SPOP	0.8818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons