DegronMD - Q9HCD6(TANC2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I1612T	TCGA-AN-A046	BRCA	TCGA	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.0556
p.I1628T	TCGA-AP-A056	UCEC	TCGA	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.2778
p.S1625N	TCGA-AP-A059	UCEC	TCGA	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation altering degron motif	0.7069
p.V1622I	TCGA-AX-A3G9	UCEC	TCGA	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation altering degron motif	0.7076
p.V1622I	TCGA-BR-6566	STAD	TCGA	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation altering degron motif	0.7076
p.V1622I	SIDM00502	B-Lymphoblastic Leukemia	GDSC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation altering degron motif	0.7076
p.V1622I	ACH-000157	Lymphoma	CCLE	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation altering degron motif	0.7076
p.V1622I	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation altering degron motif	0.7076
p.R265Q	TCGA-AZ-6601	COAD	TCGA	AATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1944
p.R265Q	DO8119	COAD	ICGC	AATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1944
p.A183S	TCGA-D3-A2JP	SKCM	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	178:184	Mutation altering degron motif	0.6477
p.A183S	DO47407	SKCM	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	178:184	Mutation altering degron motif	0.6477
p.P170S	TCGA-ER-A2NB	SKCM	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	178:184	Mutation rewiring degron network	0.1111
p.P170S	DO47448	SKCM	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	178:184	Mutation rewiring degron network	0.1111
p.R177T	TCGA-FD-A6TA	BLCA	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	178:184	Mutation rewiring degron network	0.3056
p.R177T	DO49753	BLCA	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	178:184	Mutation rewiring degron network	0.3056
p.P1620S	TCGA-P5-A5ET	LGG	TCGA	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.2778
p.I1622T	DO1285	BRCA	ICGC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation altering degron motif	0.7078
p.G1612R	DO7819	COAD	ICGC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.0556
p.Y188S	DO222891	COCA	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	178:184	Mutation rewiring degron network	0.2222
p.V1632I	DO233649	GACA	ICGC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.1667
p.V1632I	DO38217	STAD	ICGC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.1667
p.V1632I	DO41241	UCEC	ICGC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.1667
p.V1632I	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.1667
p.P1630S	DO50158	LGG	ICGC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.2222
p.S176I	DO228974	LICA	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	178:184	Mutation blocking phosphorylation signal	0.7222
p.R194L	DO228978	LICA	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	178:184	Mutation rewiring degron network	0.0556
p.P1628S	DO50890	LICA	ICGC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.2778
p.V192G	DO229130	NKTL	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	178:184	Mutation rewiring degron network	0.1111
p.S1635N	DO41361	UCEC	ICGC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.0833
p.L280V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1667
p.L280V	ACH-000888	Lung Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1667
p.L280V	NCI-H1793	lung	COSMIC	AATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1667
p.A1632V	SIDM01573	Plasma Cell Myeloma	GDSC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.1667
p.A1632V	ACH-000576	Myeloma	CCLE	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.1667
p.I1628V	SIDM01424	B-Lymphoblastic Leukemia	GDSC	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.2778
p.I1628V	ACH-000782	Leukemia	CCLE	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.2778
p.I1628V	ACH-001735	Leukemia	CCLE	VHSST	DEG_SPOP_SBC_1	1622:1626	Mutation rewiring degron network	0.2778
p.E193K	ACH-000923	Lymphoma	CCLE	DSGIIAT	DEG_SCF_TRCP1_1	178:184	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TANC2

UniProt ID: Q9HCD6

Entrez ID: 26115

Protein name: Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TANC2 in