DegronMD

Uniprot ID: Q9HCD6

Source protein: Protein TANC2

Source gene: TANC2

Class: DEG_SCF_TRCP1_1

Location: 178:184

E3 ligase: BTRC

DEGRON score: 0.9699

ASA_SCORE: 60.8571

COIL: 0.5404

CONS_SCORE: 0.3935

DSS_SCORE: 0.4126

HELIX: 0.0534

FCONS_SCORE: 1.0855

RIG_SCORE: 0.7734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A183S	TCGA-D3-A2JP	SKCM	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	0.6477
p.A183S	DO47407	SKCM	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.6477
p.P170S	TCGA-ER-A2NB	SKCM	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	0.1111
p.P170S	DO47448	SKCM	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.1111
p.R177T	TCGA-FD-A6TA	BLCA	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	0.3056
p.R177T	DO49753	BLCA	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.3056
p.Y188S	DO222891	COCA	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.2222
p.S176I	DO228974	LICA	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.7222
p.R194L	DO228978	LICA	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.0556
p.V192G	DO229130	NKTL	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.1111
p.E193K	ACH-000923	Lymphoma	CCLE	DSGIIAT	DEG_SCF_TRCP1_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons