DegronMD

Uniprot ID: Q9C0D5

Source protein: Protein TANC1

Source gene: TANC1

Class: DEG_SCF_TRCP1_1

Location: 223:229

E3 ligase: BTRC

DEGRON score: 0.998

ASA_SCORE: 70.6143

COIL: 0.7747

CONS_SCORE: 0.4178

DSS_SCORE: 0.5304

HELIX: 0.0526

FCONS_SCORE: 1.0832

RIG_SCORE: 0.7103

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S216T	TCGA-AG-A00Y	READ	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	0.1389
p.S216T	DO36542	READ	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.1389
p.S232R	TCGA-AP-A059	UCEC	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	0.25
p.S232R	DO41361	UCEC	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.25
p.G225R	TCGA-AX-A1CK	UCEC	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	0.7568
p.G225R	DO41815	UCEC	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.7568
p.I226N	TCGA-D8-A1XK	BRCA	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	0.6169
p.I226N	DO4749	BRCA	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.6169
p.I226M	DO220333	KICH	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.6507
p.S217Y	DO52385	LUSC	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.6111
p.S217T	DO52385	LUSC	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	0.6111
p.E235K	SIDM00419	Ewing's Sarcoma	GDSC	DSGIIAT	DEG_SCF_TRCP1_1	0.1667
p.E235K	SIDM00136	Colorectal Carcinoma	GDSC	DSGIIAT	DEG_SCF_TRCP1_1	0.1667
p.E235K	SIDM01629	Melanoma	GDSC	DSGIIAT	DEG_SCF_TRCP1_1	0.1667
p.E235K	HT-29	large_intestine	COSMIC	DSGIIAT	DEG_SCF_TRCP1_1	0.1667
p.E235K	TC-71	bone	COSMIC	DSGIIAT	DEG_SCF_TRCP1_1	0.1667
p.L219M	DB	haematopoietic_and_lymphoid_tissue	COSMIC	DSGIIAT	DEG_SCF_TRCP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons