DegronMD - Q9C0D5(TANC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1449V	TCGA-24-2288	OV	TCGA	PTPGLS	DEG_SCF_FBW7_1	1446:1451	Mutation altering degron motif	0.6421
p.G1449V	DO29166	OV	ICGC	PTPGLS	DEG_SCF_FBW7_1	1446:1451	Mutation altering degron motif	0.6421
p.S1564T	TCGA-25-2392	OV	TCGA	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation blocking phosphorylation signal	0.6111
p.S1564T	DO28102	OV	ICGC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation blocking phosphorylation signal	0.6111
p.D457Y	TCGA-49-AARO	LUAD	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation rewiring degron network	0.3056
p.D457Y	TCGA-49-AARO	LUAD	TCGA	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0833
p.D457Y	DO218924	LUAD	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation rewiring degron network	0.3056
p.D457Y	DO218924	LUAD	ICGC	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0833
p.S467T	TCGA-63-A5MB	LUSC	TCGA	PSSST	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.6005
p.S467T	DO52018	LUSC	ICGC	PSSST	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.6005
p.S216T	TCGA-AG-A00Y	READ	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.1389
p.S216T	DO36542	READ	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.1389
p.S232R	TCGA-AP-A059	UCEC	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.25
p.S232R	DO41361	UCEC	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.25
p.D453E	TCGA-AP-A059	UCEC	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation rewiring degron network	0.1944
p.D453E	DO41361	UCEC	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation rewiring degron network	0.1944
p.G225R	TCGA-AX-A1CK	UCEC	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation altering degron motif	0.7568
p.G225R	DO41815	UCEC	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation altering degron motif	0.7568
p.Q456H	TCGA-AX-A3FS	UCEC	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation rewiring degron network	0.2778
p.Q456H	TCGA-AX-A3FS	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0556
p.Q456H	DO40879	UCEC	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation rewiring degron network	0.2778
p.Q456H	DO40879	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0556
p.R310G	TCGA-BR-7717	STAD	TCGA	AATSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.1944
p.R310G	DO38412	STAD	ICGC	AATSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.1944
p.E1442K	TCGA-BR-8487	STAD	TCGA	PTPGLS	DEG_SCF_FBW7_1	1446:1451	Mutation rewiring degron network	0.2222
p.E1442K	DO47867	STAD	ICGC	PTPGLS	DEG_SCF_FBW7_1	1446:1451	Mutation rewiring degron network	0.2222
p.P462T	TCGA-D1-A103	UCEC	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation altering degron motif	0.7031
p.P462T	DO42312	UCEC	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation altering degron motif	0.7031
p.I226N	TCGA-D8-A1XK	BRCA	TCGA	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation altering degron motif	0.6169
p.I226N	DO4749	BRCA	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation altering degron motif	0.6169
p.L480I	TCGA-DA-A1IB	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0556
p.L480I	DO38033	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0556
p.E1440K	TCGA-DR-A0ZM	CESC	TCGA	PTPGLS	DEG_SCF_FBW7_1	1446:1451	Mutation rewiring degron network	0.1667
p.E1440K	DO6254	CESC	ICGC	PTPGLS	DEG_SCF_FBW7_1	1446:1451	Mutation rewiring degron network	0.1667
p.P479H	TCGA-DU-6392	LGG	TCGA	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0833
p.P479H	DO22237	LGG	ICGC	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0833
p.P462S	TCGA-EE-A29E	SKCM	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation altering degron motif	0.6752
p.P462S	DO37831	SKCM	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation altering degron motif	0.6752
p.P1574S	TCGA-EE-A3JI	SKCM	TCGA	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.6752
p.P1574S	DO47268	SKCM	ICGC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.6752
p.P1574L	TCGA-EE-A3JI	SKCM	TCGA	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.7582
p.P1574L	DO47268	SKCM	ICGC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.7582
p.L464F	TCGA-EY-A1G8	UCEC	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation altering degron motif	0.587
p.L464F	DO43578	UCEC	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation altering degron motif	0.587
p.P466L	TCGA-EY-A1GI	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.7582
p.P466L	DO41211	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.7582
p.P466Q	TCGA-F7-A624	HNSC	TCGA	PSSST	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.7035
p.P466Q	DO44440	HNSC	ICGC	PSSST	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.7035
p.S471I	TCGA-MX-A5UJ	STAD	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation rewiring degron network	0.1667
p.S471I	TCGA-MX-A5UJ	STAD	TCGA	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.3056
p.S471I	DO48547	STAD	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation rewiring degron network	0.1667
p.S471I	DO48547	STAD	ICGC	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.3056
p.T1573A	DO229010	COCA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.7139
p.T1573A	DO229013	COCA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.7139
p.T1573A	DO229016	COCA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.7139
p.T1573A	DO229003	COCA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.7139
p.T1573A	DO229005	COCA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.7139
p.T1573A	DO234285	ESAD	ICGC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.7139
p.F460L	DO234425	ESAD	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation altering degron motif	0.587
p.S473F	DO223157	ESCA	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation rewiring degron network	0.1111
p.S473F	DO223157	ESCA	ICGC	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.25
p.I226M	DO220333	KICH	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation altering degron motif	0.6507
p.R1578I	DO228978	LICA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.3056
p.R1578I	DO229027	LICA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.3056
p.L463F	DO229026	LICA	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation altering degron motif	0.587
p.S217Y	DO52385	LUSC	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation blocking phosphorylation signal	0.6111
p.S217T	DO52385	LUSC	ICGC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation blocking phosphorylation signal	0.6111
p.S465L	DO220891	MELA	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	458:465	Mutation altering degron motif	0.8778
p.A316P	DO232689	PBCA	ICGC	AATSS	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.6392
p.A1571V	SIDM00557	Neuroblastoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	SIDM00498	Colorectal Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	SIDM00488	Colorectal Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	SIDM00239	Kidney Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	SIDM00988	Kidney Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	SIDM01018	Hodgkin's Lymphoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	SIDM01781	Gastric Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	CaR-1	large intestine	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	BFTC-909	kidney	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	KM-H2	haematopoietic and lymphoid tissue	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	OS-RC-2	kidney	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	TE-10	oesophagus	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A1571V	LU-65	lung	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation altering degron motif	0.5825
p.A476T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1667
p.A476T	ACH-000983	Leukemia	CCLE	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1667
p.A476T	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1667
p.G1568V	SIDM00915	Small Cell Lung Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.2778
p.G1568V	SIDM01099	Neuroblastoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.2778
p.G1568V	SIDM00995	Other Solid Cancers	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.2778
p.G1568V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.2778
p.G1568V	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.2778
p.G1568V	SIDM00793	Burkitt's Lymphoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.2778
p.G1568V	SIDM00721	Small Cell Lung Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.2778
p.G1568V	SIDM00261	Ewing's Sarcoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.2778
p.G1568V	SIDM00808	Burkitt's Lymphoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.2778
p.G1568V	SIDM00760	Small Cell Lung Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.2778
p.G1568V	SIDM01254	Burkitt's Lymphoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.2778
p.E235K	SIDM00419	Ewing's Sarcoma	GDSC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.1667
p.E235K	SIDM00136	Colorectal Carcinoma	GDSC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.1667
p.E235K	SIDM01629	Melanoma	GDSC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.1667
p.E235K	HT-29	large intestine	COSMIC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.1667
p.E235K	TC-71	bone	COSMIC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.1667
p.R1569T	SIDM00963	Breast Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.3056
p.R1569T	BT-474	breast	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	1570:1577	Mutation rewiring degron network	0.3056
p.F1454L	SIDM00853	Other Sarcomas	GDSC	PTPGLS	DEG_SCF_FBW7_1	1446:1451	Mutation rewiring degron network	0.25
p.H1455Y	SIDM00853	Other Sarcomas	GDSC	PTPGLS	DEG_SCF_FBW7_1	1446:1451	Mutation rewiring degron network	0.2222
p.P311S	SIDM00140	Melanoma	GDSC	AATSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.2222
p.P311S	ACH-000968	Skin Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.2222
p.P311S	COLO-792	skin	COSMIC	AATSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.2222
p.L219M	DB	haematopoietic and lymphoid tissue	COSMIC	DSGIIAT	DEG_SCF_TRCP1_1	223:229	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TANC1

UniProt ID: Q9C0D5

Entrez ID: 85461

Protein name: Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TANC1 in