DegronMD

Uniprot ID: Q9C0D5

Source protein: Protein TANC1

Source gene: TANC1

Class: DEG_SCF_FBW7_1

Location: 458:465

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 66.225

COIL: 0.7411

CONS_SCORE: 0.2513

DSS_SCORE: 0.6536

HELIX: 0.1163

FCONS_SCORE: 1.0195

RIG_SCORE: 0.6913

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D457Y	TCGA-49-AARO	LUAD	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	0.3056
p.D457Y	DO218924	LUAD	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	0.3056
p.D453E	TCGA-AP-A059	UCEC	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	0.1944
p.D453E	DO41361	UCEC	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	0.1944
p.Q456H	TCGA-AX-A3FS	UCEC	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	0.2778
p.Q456H	DO40879	UCEC	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	0.2778
p.P462T	TCGA-D1-A103	UCEC	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	0.7031
p.P462T	DO42312	UCEC	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	0.7031
p.P462S	TCGA-EE-A29E	SKCM	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	0.6752
p.P462S	DO37831	SKCM	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	0.6752
p.L464F	TCGA-EY-A1G8	UCEC	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	0.587
p.L464F	DO43578	UCEC	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	0.587
p.S471I	TCGA-MX-A5UJ	STAD	TCGA	LHFTPLLS	DEG_SCF_FBW7_1	0.1667
p.S471I	DO48547	STAD	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	0.1667
p.F460L	DO234425	ESAD	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	0.587
p.S473F	DO223157	ESCA	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	0.1111
p.L463F	DO229026	LICA	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	0.587
p.S465L	DO220891	MELA	ICGC	LHFTPLLS	DEG_SCF_FBW7_1	0.8778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0D5	Protein TANC1	DEG_SCF_FBW7_1	458:465	LHFTPLLS	FBXW7	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons