DegronMD

Uniprot ID: Q9C0D5

Source protein: Protein TANC1

Source gene: TANC1

Class: DEG_SCF_FBW7_1

Location: 1570:1577

E3 ligase: FBXW7

DEGRON score: 0.9921

ASA_SCORE: 64.25

COIL: 0.8995

CONS_SCORE: 0.2782

DSS_SCORE: 0.7645

HELIX: 0.0459

FCONS_SCORE: 1.0566

RIG_SCORE: 0.6338

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1564T	TCGA-25-2392	OV	TCGA	IAATPAGS	DEG_SCF_FBW7_1	0.6111
p.S1564T	DO28102	OV	ICGC	IAATPAGS	DEG_SCF_FBW7_1	0.6111
p.P1574S	TCGA-EE-A3JI	SKCM	TCGA	IAATPAGS	DEG_SCF_FBW7_1	0.6752
p.P1574S	DO47268	SKCM	ICGC	IAATPAGS	DEG_SCF_FBW7_1	0.6752
p.P1574L	TCGA-EE-A3JI	SKCM	TCGA	IAATPAGS	DEG_SCF_FBW7_1	0.7582
p.P1574L	DO47268	SKCM	ICGC	IAATPAGS	DEG_SCF_FBW7_1	0.7582
p.T1573A	DO229010	COCA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	0.7139
p.T1573A	DO229013	COCA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	0.7139
p.T1573A	DO229016	COCA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	0.7139
p.T1573A	DO229003	COCA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	0.7139
p.T1573A	DO229005	COCA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	0.7139
p.T1573A	DO234285	ESAD	ICGC	IAATPAGS	DEG_SCF_FBW7_1	0.7139
p.R1578I	DO228978	LICA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	0.3056
p.R1578I	DO229027	LICA	ICGC	IAATPAGS	DEG_SCF_FBW7_1	0.3056
p.A1571V	SIDM00557	Neuroblastoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	SIDM00498	Colorectal Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	SIDM00488	Colorectal Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	SIDM00239	Kidney Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	SIDM00988	Kidney Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	SIDM01018	Hodgkin's Lymphoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	SIDM01781	Gastric Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	CaR-1	large_intestine	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	BFTC-909	kidney	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	OS-RC-2	kidney	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	TE-10	oesophagus	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.A1571V	LU-65	lung	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	0.5825
p.G1568V	SIDM00915	Small Cell Lung Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.2778
p.G1568V	SIDM01099	Neuroblastoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.2778
p.G1568V	SIDM00995	Other Solid Cancers	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.2778
p.G1568V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.2778
p.G1568V	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.2778
p.G1568V	SIDM00793	Burkitt's Lymphoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.2778
p.G1568V	SIDM00721	Small Cell Lung Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.2778
p.G1568V	SIDM00261	Ewing's Sarcoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.2778
p.G1568V	SIDM00808	Burkitt's Lymphoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.2778
p.G1568V	SIDM00760	Small Cell Lung Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.2778
p.G1568V	SIDM01254	Burkitt's Lymphoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.2778
p.R1569T	SIDM00963	Breast Carcinoma	GDSC	IAATPAGS	DEG_SCF_FBW7_1	0.3056
p.R1569T	BT-474	breast	COSMIC	IAATPAGS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAATPAGS

Degron related mutations and impact score

Drug responses associated with TANC1 mutations

All proteins holding degron of IAATPAGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0D5	Protein TANC1	DEG_SCF_FBW7_1	1570:1577	IAATPAGS	FBXW7	0.9921	More...