DegronMD

Uniprot ID: Q9C0D5

Source protein: Protein TANC1

Source gene: TANC1

Class: DEG_SCF_FBW7_1

Location: 1446:1451

E3 ligase: FBXW7

DEGRON score: 0.9762

ASA_SCORE: 65.9

COIL: 0.823

CONS_SCORE: 0.3636

DSS_SCORE: 0.9332

HELIX: 0.1493

FCONS_SCORE: 1.2179

RIG_SCORE: 0.5043

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1449V	TCGA-24-2288	OV	TCGA	PTPGLS	DEG_SCF_FBW7_1	0.6421
p.G1449V	DO29166	OV	ICGC	PTPGLS	DEG_SCF_FBW7_1	0.6421
p.E1442K	TCGA-BR-8487	STAD	TCGA	PTPGLS	DEG_SCF_FBW7_1	0.2222
p.E1442K	DO47867	STAD	ICGC	PTPGLS	DEG_SCF_FBW7_1	0.2222
p.E1440K	TCGA-DR-A0ZM	CESC	TCGA	PTPGLS	DEG_SCF_FBW7_1	0.1667
p.E1440K	DO6254	CESC	ICGC	PTPGLS	DEG_SCF_FBW7_1	0.1667
p.F1454L	SIDM00853	Other Sarcomas	GDSC	PTPGLS	DEG_SCF_FBW7_1	0.25
p.H1455Y	SIDM00853	Other Sarcomas	GDSC	PTPGLS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0D5	Protein TANC1	DEG_SCF_FBW7_1	1446:1451	PTPGLS	FBXW7	0.9762	More...
Q9UL45	Biogenesis of lysosome-related organelles complex 1 subunit 6	DEG_SCF_FBW7_1	25:30	PTPGLS	FBXW7	0.8922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons