DegronMD

Uniprot ID: Q9UL45

Source protein: Biogenesis of lysosome-related organelles complex 1 subunit 6

Source gene: BLOC1S6

Class: DEG_SCF_FBW7_1

Location: 25:30

E3 ligase: FBXW7

DEGRON score: 0.8922

ASA_SCORE: 72.25

COIL: 0.8358

CONS_SCORE: 0.3329

DSS_SCORE: 0.7225

HELIX: 0.0482

FCONS_SCORE: 0.8781

RIG_SCORE: 0.6047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L20M	TCGA-AP-A1DK	UCEC	TCGA	PTPGLS	DEG_SCF_FBW7_1	0.1944
p.L20M	DO42033	UCEC	ICGC	PTPGLS	DEG_SCF_FBW7_1	0.1944
p.E40K	TCGA-BR-A4QL	STAD	TCGA	PTPGLS	DEG_SCF_FBW7_1	0.0556
p.I39V	TCGA-D1-A17Q	UCEC	TCGA	PTPGLS	DEG_SCF_FBW7_1	0.0833
p.D35N	TCGA-FD-A3SO	BLCA	TCGA	PTPGLS	DEG_SCF_FBW7_1	0.1944
p.D35N	DO569	BLCA	ICGC	PTPGLS	DEG_SCF_FBW7_1	0.1944
p.L38S	DO219738	CESC	ICGC	PTPGLS	DEG_SCF_FBW7_1	0.1111
p.C19F	DO228978	LICA	ICGC	PTPGLS	DEG_SCF_FBW7_1	0.1667
p.S30R	DO228418	MALY	ICGC	PTPGLS	DEG_SCF_FBW7_1	0.7427
p.C19S	DO52126	PAEN	ICGC	PTPGLS	DEG_SCF_FBW7_1	0.1667
p.V39A	DO41871	UCEC	ICGC	PTPGLS	DEG_SCF_FBW7_1	0.0833
p.G28S	SIDM01314	Colorectal Carcinoma	GDSC	PTPGLS	DEG_SCF_FBW7_1	0.5882
p.R22K	ACH-000541	Myeloma	CCLE	PTPGLS	DEG_SCF_FBW7_1	0.25
p.E31K	TT	thyroid	COSMIC	PTPGLS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0D5	Protein TANC1	DEG_SCF_FBW7_1	1446:1451	PTPGLS	FBXW7	0.9762	More...
Q9UL45	Biogenesis of lysosome-related organelles complex 1 subunit 6	DEG_SCF_FBW7_1	25:30	PTPGLS	FBXW7	0.8922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons