DegronMD

Uniprot ID: Q9HCD6

Source protein: Protein TANC2

Source gene: TANC2

Class: DEG_SPOP_SBC_1

Location: 1622:1626

E3 ligase: SPOP

DEGRON score: 0.9669

ASA_SCORE: 83.32

COIL: 0.8382

CONS_SCORE: 0.2894

DSS_SCORE: 0.5223

HELIX: 0.0772

FCONS_SCORE: 1.0259

RIG_SCORE: 0.6755

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1612T	TCGA-AN-A046	BRCA	TCGA	VHSST	DEG_SPOP_SBC_1	0.0556
p.I1628T	TCGA-AP-A056	UCEC	TCGA	VHSST	DEG_SPOP_SBC_1	0.2778
p.S1625N	TCGA-AP-A059	UCEC	TCGA	VHSST	DEG_SPOP_SBC_1	0.7069
p.V1622I	TCGA-AX-A3G9	UCEC	TCGA	VHSST	DEG_SPOP_SBC_1	0.7076
p.V1622I	TCGA-BR-6566	STAD	TCGA	VHSST	DEG_SPOP_SBC_1	0.7076
p.V1622I	SIDM00502	B-Lymphoblastic Leukemia	GDSC	VHSST	DEG_SPOP_SBC_1	0.7076
p.V1622I	ACH-000157	Lymphoma	CCLE	VHSST	DEG_SPOP_SBC_1	0.7076
p.V1622I	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	VHSST	DEG_SPOP_SBC_1	0.7076
p.P1620S	TCGA-P5-A5ET	LGG	TCGA	VHSST	DEG_SPOP_SBC_1	0.2778
p.I1622T	DO1285	BRCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.7078
p.G1612R	DO7819	COAD	ICGC	VHSST	DEG_SPOP_SBC_1	0.0556
p.V1632I	DO233649	GACA	ICGC	VHSST	DEG_SPOP_SBC_1	0.1667
p.V1632I	DO38217	STAD	ICGC	VHSST	DEG_SPOP_SBC_1	0.1667
p.V1632I	DO41241	UCEC	ICGC	VHSST	DEG_SPOP_SBC_1	0.1667
p.V1632I	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	VHSST	DEG_SPOP_SBC_1	0.1667
p.P1630S	DO50158	LGG	ICGC	VHSST	DEG_SPOP_SBC_1	0.2222
p.P1628S	DO50890	LICA	ICGC	VHSST	DEG_SPOP_SBC_1	0.2778
p.S1635N	DO41361	UCEC	ICGC	VHSST	DEG_SPOP_SBC_1	0.0833
p.A1632V	SIDM01573	Plasma Cell Myeloma	GDSC	VHSST	DEG_SPOP_SBC_1	0.1667
p.A1632V	ACH-000576	Myeloma	CCLE	VHSST	DEG_SPOP_SBC_1	0.1667
p.I1628V	SIDM01424	B-Lymphoblastic Leukemia	GDSC	VHSST	DEG_SPOP_SBC_1	0.2778
p.I1628V	ACH-000782	Leukemia	CCLE	VHSST	DEG_SPOP_SBC_1	0.2778
p.I1628V	ACH-001735	Leukemia	CCLE	VHSST	DEG_SPOP_SBC_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons