DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 4446:4450

E3 ligase: SPOP

DEGRON score: 0.7686

ASA_SCORE: 95.26

COIL: 0.9186

CONS_SCORE: 0

DSS_SCORE: 0.675

HELIX: 0.0144

FCONS_SCORE: 0

RIG_SCORE: 0.5767

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A4436T	DO228967	LICA	ICGC	VHSST	DEG_SPOP_SBC_1	0.0556
p.A4436T	DO222749	MELA	ICGC	VHSST	DEG_SPOP_SBC_1	0.0556
p.S4452L	DO220903	MELA	ICGC	VHSST	DEG_SPOP_SBC_1	0.2778
p.H4447Y	DO37432	SKCM	ICGC	VHSST	DEG_SPOP_SBC_1	0.6118
p.L4440I	DO229259	THCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.1667
p.T4454P	SIDM02054	Esophageal Carcinoma	GDSC	VHSST	DEG_SPOP_SBC_1	0.2222
p.L4457M	ACH-000900	Lung Cancer	CCLE	VHSST	DEG_SPOP_SBC_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons