DegronMD - Q9UQR1(ZNF148)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S665Y	TCGA-06-5416	GBM	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation blocking phosphorylation signal	0.7222
p.S665Y	TCGA-AJ-A5DW	UCEC	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation blocking phosphorylation signal	0.7222
p.S665Y	DO10880	GBM	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation blocking phosphorylation signal	0.7222
p.S665Y	DO50075	UCEC	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation blocking phosphorylation signal	0.7222
p.M74I	TCGA-52-7810	LUSC	TCGA	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1667
p.M74I	DO27381	LUSC	ICGC	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1667
p.N310K	TCGA-61-1722	OV	TCGA	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation rewiring degron network	0.2222
p.N310K	DO31190	OV	ICGC	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation rewiring degron network	0.2222
p.S683L	TCGA-85-A50M	LUSC	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation rewiring degron network	0.0833
p.S683L	DO45546	LUSC	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation rewiring degron network	0.0833
p.G588V	TCGA-99-8032	LUAD	TCGA	VGSSS	DEG_SPOP_SBC_1	587:591	Mutation altering degron motif	0.6421
p.G588V	DO23765	LUAD	ICGC	VGSSS	DEG_SPOP_SBC_1	587:591	Mutation altering degron motif	0.6421
p.D300Y	TCGA-A5-A0G2	UCEC	TCGA	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation altering degron motif	0.7325
p.D300Y	DO41235	UCEC	ICGC	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation altering degron motif	0.7325
p.R668I	TCGA-AG-A002	READ	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation altering degron motif	0.6991
p.D465A	TCGA-B5-A1MR	UCEC	TCGA	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.25
p.D465A	DO41758	UCEC	ICGC	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.25
p.P457H	TCGA-B5-A3FC	UCEC	TCGA	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.3056
p.P457H	DO41871	UCEC	ICGC	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.3056
p.K472E	TCGA-B7-5818	STAD	TCGA	VHSST	DEG_SPOP_SBC_1	458:462	Mutation blocking ubiquitination signal	0.5
p.K472E	DO38883	STAD	ICGC	VHSST	DEG_SPOP_SBC_1	458:462	Mutation blocking ubiquitination signal	0.5
p.H675Y	TCGA-DD-AAE0	LIHC	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation rewiring degron network	0.3056
p.H675Y	DO52253	LIHC	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation rewiring degron network	0.3056
p.H83N	TCGA-EE-A2GN	SKCM	TCGA	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.7423
p.H83N	DO37896	SKCM	ICGC	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.7423
p.V562D	TCGA-EO-A22R	UCEC	TCGA	SINSSEVPEV	DEG_COP1_1	572:581	Mutation rewiring degron network	0.0556
p.V562D	DO42713	UCEC	ICGC	SINSSEVPEV	DEG_COP1_1	572:581	Mutation rewiring degron network	0.0556
p.N574H	TCGA-EO-A3AY	UCEC	TCGA	SINSSEVPEV	DEG_COP1_1	572:581	Mutation altering degron motif	0.6312
p.N574H	DO43202	UCEC	ICGC	SINSSEVPEV	DEG_COP1_1	572:581	Mutation altering degron motif	0.6312
p.S575Y	TCGA-EO-A3B0	UCEC	TCGA	SINSSEVPEV	DEG_COP1_1	572:581	Mutation altering degron motif	0.712
p.S575Y	DO219773	UCEC	ICGC	SINSSEVPEV	DEG_COP1_1	572:581	Mutation altering degron motif	0.712
p.P583Q	TCGA-ER-A195	SKCM	TCGA	SINSSEVPEV	DEG_COP1_1	572:581	Mutation rewiring degron network	0.2778
p.P583Q	TCGA-ER-A195	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2222
p.P583Q	DO47712	SKCM	ICGC	SINSSEVPEV	DEG_COP1_1	572:581	Mutation rewiring degron network	0.2778
p.P583Q	DO47712	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2222
p.P583Q	SIDM00845	Burkitt's Lymphoma	GDSC	SINSSEVPEV	DEG_COP1_1	572:581	Mutation rewiring degron network	0.2778
p.P583Q	SIDM00845	Burkitt's Lymphoma	GDSC	VGSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2222
p.P583Q	SIDM00035	Thyroid Gland Carcinoma	GDSC	SINSSEVPEV	DEG_COP1_1	572:581	Mutation rewiring degron network	0.2778
p.P583Q	SIDM00035	Thyroid Gland Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2222
p.P583Q	SIDM01519	Head and Neck Carcinoma	GDSC	SINSSEVPEV	DEG_COP1_1	572:581	Mutation rewiring degron network	0.2778
p.P583Q	SIDM01519	Head and Neck Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2222
p.P583Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	SINSSEVPEV	DEG_COP1_1	572:581	Mutation rewiring degron network	0.2778
p.P583Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2222
p.N574D	TCGA-EY-A1G8	UCEC	TCGA	SINSSEVPEV	DEG_COP1_1	572:581	Mutation altering degron motif	0.5821
p.N574D	DO43578	UCEC	ICGC	SINSSEVPEV	DEG_COP1_1	572:581	Mutation altering degron motif	0.5821
p.P671L	TCGA-GN-A8LK	SKCM	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation altering degron motif	0.7582
p.P671L	DO51259	SKCM	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation altering degron motif	0.7582
p.G677V	TCGA-J9-A8CL	PRAD	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation rewiring degron network	0.25
p.G677V	DO219265	PRAD	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation rewiring degron network	0.25
p.D78N	TCGA-Y8-A894	KIRP	TCGA	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2778
p.D78N	DO49798	KIRP	ICGC	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2778
p.E580Q	DO48372	BLCA	ICGC	SINSSEVPEV	DEG_COP1_1	572:581	Mutation altering degron motif	0.6744
p.D465N	DO48414	BLCA	ICGC	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.25
p.Q93H	DO225328	BRCA	ICGC	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.T565S	DO224593	BRCA	ICGC	SINSSEVPEV	DEG_COP1_1	572:581	Mutation rewiring degron network	0.1389
p.T565S	DO1020	BRCA	ICGC	SINSSEVPEV	DEG_COP1_1	572:581	Mutation rewiring degron network	0.1389
p.D73N	DO222762	COCA	ICGC	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1389
p.Q71H	DO234333	ESAD	ICGC	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.0833
p.L80I	DO229045	LICA	ICGC	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.6063
p.Q72K	DO229045	LICA	ICGC	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.S674T	DO228253	MALY	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation altering degron motif	0.6005
p.E298Q	DO229130	NKTL	ICGC	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation rewiring degron network	0.2778
p.K456R	DO52139	PAEN	ICGC	VHSST	DEG_SPOP_SBC_1	458:462	Mutation blocking ubiquitination signal	0.7222
p.R70G	SIDM00845	Burkitt's Lymphoma	GDSC	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.0556
p.H77Q	SIDM00113	Kidney Carcinoma	GDSC	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.H77Q	ACH-001208	Kidney Cancer	CCLE	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.H77Q	TK10	kidney	COSMIC	LMVHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.A467S	SIDM00523	Small Cell Lung Carcinoma	GDSC	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.A467S	ACH-000698	Lung Cancer	CCLE	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.A467S	DMS-53	lung	COSMIC	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.D300N	SIDM01003	T-Lymphoblastic Leukemia	GDSC	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation altering degron motif	0.6932
p.D300N	ACH-000101	Leukemia	CCLE	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation altering degron motif	0.6932
p.D300N	KE-37	haematopoietic and lymphoid tissue	COSMIC	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation altering degron motif	0.6932
p.D300V	SIDM00511	Small Cell Lung Carcinoma	GDSC	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation altering degron motif	0.7785
p.D300V	ACH-000257	Lung Cancer	CCLE	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation altering degron motif	0.7785
p.D300V	COR-L279	lung	COSMIC	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation altering degron motif	0.7785
p.G292S	SIDM01000	Melanoma	GDSC	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation rewiring degron network	0.1111
p.G292S	ACH-000304	Skin Cancer	CCLE	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation rewiring degron network	0.1111
p.G292S	WM-115	skin	COSMIC	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation rewiring degron network	0.1111
p.M468V	SIDM00312	Plasma Cell Myeloma	GDSC	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1667
p.M468V	ACH-000183	Myeloma	CCLE	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1667
p.M468V	L-363	haematopoietic and lymphoid tissue	COSMIC	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1667
p.R660Q	SIDM00118	Colorectal Carcinoma	GDSC	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation rewiring degron network	0.1389
p.R660Q	ACH-001081	Colon/Colorectal Cancer	CCLE	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation rewiring degron network	0.1389
p.R660Q	HCC2998	large intestine	COSMIC	LRTTPDKS	DEG_SCF_FBW7_1	667:674	Mutation rewiring degron network	0.1389
p.Q469H	SIDM00528	Breast Carcinoma	GDSC	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1389
p.Q469H	ACH-000934	Breast Cancer	CCLE	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1389
p.Q469H	MDA-MB-361	breast	COSMIC	VHSST	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1389
p.S311P	ACH-000526	Non-Cancerous	CCLE	DSGFSTS	DEG_SCF_TRCP1_1	300:306	Mutation blocking phosphorylation signal	0.6389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF148

UniProt ID: Q9UQR1

Entrez ID: 7707

Protein name: Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF148 in