DegronMD

Uniprot ID: Q9UQR1

Source protein: Zinc finger protein 148

Source gene: ZNF148

Class: DEG_SCF_TRCP1_1

Location: 300:306

E3 ligase: BTRC

DEGRON score: 0.8663

ASA_SCORE: 57.6286

COIL: 0.69

CONS_SCORE: 0.4704

DSS_SCORE: 0.5816

HELIX: 0.0543

FCONS_SCORE: 0.8583

RIG_SCORE: 0.608

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N310K	TCGA-61-1722	OV	TCGA	DSGFSTS	DEG_SCF_TRCP1_1	0.2222
p.N310K	DO31190	OV	ICGC	DSGFSTS	DEG_SCF_TRCP1_1	0.2222
p.D300Y	TCGA-A5-A0G2	UCEC	TCGA	DSGFSTS	DEG_SCF_TRCP1_1	0.7325
p.D300Y	DO41235	UCEC	ICGC	DSGFSTS	DEG_SCF_TRCP1_1	0.7325
p.E298Q	DO229130	NKTL	ICGC	DSGFSTS	DEG_SCF_TRCP1_1	0.2778
p.D300N	SIDM01003	T-Lymphoblastic Leukemia	GDSC	DSGFSTS	DEG_SCF_TRCP1_1	0.6932
p.D300N	ACH-000101	Leukemia	CCLE	DSGFSTS	DEG_SCF_TRCP1_1	0.6932
p.D300N	KE-37	haematopoietic_and_lymphoid_tissue	COSMIC	DSGFSTS	DEG_SCF_TRCP1_1	0.6932
p.D300V	SIDM00511	Small Cell Lung Carcinoma	GDSC	DSGFSTS	DEG_SCF_TRCP1_1	0.7785
p.D300V	ACH-000257	Lung Cancer	CCLE	DSGFSTS	DEG_SCF_TRCP1_1	0.7785
p.D300V	COR-L279	lung	COSMIC	DSGFSTS	DEG_SCF_TRCP1_1	0.7785
p.G292S	SIDM01000	Melanoma	GDSC	DSGFSTS	DEG_SCF_TRCP1_1	0.1111
p.G292S	ACH-000304	Skin Cancer	CCLE	DSGFSTS	DEG_SCF_TRCP1_1	0.1111
p.G292S	WM-115	skin	COSMIC	DSGFSTS	DEG_SCF_TRCP1_1	0.1111
p.S311P	ACH-000526	Non-Cancerous	CCLE	DSGFSTS	DEG_SCF_TRCP1_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQR1	Zinc finger protein 148	DEG_SCF_TRCP1_1	300:306	DSGFSTS	BTRC	0.8663	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons