DegronMD

Uniprot ID: Q9UQR1

Source protein: Zinc finger protein 148

Source gene: ZNF148

Class: DEG_COP1_1

Location: 572:581

E3 ligase: COP1

DEGRON score: 0.9529

ASA_SCORE: 76.31

COIL: 0.7786

CONS_SCORE: 0.5489

DSS_SCORE: 0.5548

HELIX: 0.0405

FCONS_SCORE: 0.9722

RIG_SCORE: 0.675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V562D	TCGA-EO-A22R	UCEC	TCGA	SINSSEVPEV	DEG_COP1_1	0.0556
p.V562D	DO42713	UCEC	ICGC	SINSSEVPEV	DEG_COP1_1	0.0556
p.N574H	TCGA-EO-A3AY	UCEC	TCGA	SINSSEVPEV	DEG_COP1_1	0.6312
p.N574H	DO43202	UCEC	ICGC	SINSSEVPEV	DEG_COP1_1	0.6312
p.S575Y	TCGA-EO-A3B0	UCEC	TCGA	SINSSEVPEV	DEG_COP1_1	0.712
p.S575Y	DO219773	UCEC	ICGC	SINSSEVPEV	DEG_COP1_1	0.712
p.P583Q	TCGA-ER-A195	SKCM	TCGA	SINSSEVPEV	DEG_COP1_1	0.2778
p.P583Q	DO47712	SKCM	ICGC	SINSSEVPEV	DEG_COP1_1	0.2778
p.P583Q	SIDM00845	Burkitt's Lymphoma	GDSC	SINSSEVPEV	DEG_COP1_1	0.2778
p.P583Q	SIDM00035	Thyroid Gland Carcinoma	GDSC	SINSSEVPEV	DEG_COP1_1	0.2778
p.P583Q	SIDM01519	Head and Neck Carcinoma	GDSC	SINSSEVPEV	DEG_COP1_1	0.2778
p.P583Q	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SINSSEVPEV	DEG_COP1_1	0.2778
p.N574D	TCGA-EY-A1G8	UCEC	TCGA	SINSSEVPEV	DEG_COP1_1	0.5821
p.N574D	DO43578	UCEC	ICGC	SINSSEVPEV	DEG_COP1_1	0.5821
p.E580Q	DO48372	BLCA	ICGC	SINSSEVPEV	DEG_COP1_1	0.6744
p.T565S	DO224593	BRCA	ICGC	SINSSEVPEV	DEG_COP1_1	0.1389
p.T565S	DO1020	BRCA	ICGC	SINSSEVPEV	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQR1	Zinc finger protein 148	DEG_COP1_1	572:581	SINSSEVPEV	COP1	0.9529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons