DegronMD

Uniprot ID: Q9UQR1

Source protein: Zinc finger protein 148

Source gene: ZNF148

Class: LIG_APCC_ABBA_1

Location: 80:85

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9752

ASA_SCORE: 98.9

COIL: 0.7617

CONS_SCORE: 0.6618

DSS_SCORE: 0.6286

HELIX: 0.0767

FCONS_SCORE: 1.2635

RIG_SCORE: 0.7262

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M74I	TCGA-52-7810	LUSC	TCGA	LMVHEE	LIG_APCC_ABBA_1	0.1667
p.M74I	DO27381	LUSC	ICGC	LMVHEE	LIG_APCC_ABBA_1	0.1667
p.H83N	TCGA-EE-A2GN	SKCM	TCGA	LMVHEE	LIG_APCC_ABBA_1	0.7423
p.H83N	DO37896	SKCM	ICGC	LMVHEE	LIG_APCC_ABBA_1	0.7423
p.D78N	TCGA-Y8-A894	KIRP	TCGA	LMVHEE	LIG_APCC_ABBA_1	0.2778
p.D78N	DO49798	KIRP	ICGC	LMVHEE	LIG_APCC_ABBA_1	0.2778
p.Q93H	DO225328	BRCA	ICGC	LMVHEE	LIG_APCC_ABBA_1	0.1111
p.D73N	DO222762	COCA	ICGC	LMVHEE	LIG_APCC_ABBA_1	0.1389
p.Q71H	DO234333	ESAD	ICGC	LMVHEE	LIG_APCC_ABBA_1	0.0833
p.L80I	DO229045	LICA	ICGC	LMVHEE	LIG_APCC_ABBA_1	0.6063
p.Q72K	DO229045	LICA	ICGC	LMVHEE	LIG_APCC_ABBA_1	0.1111
p.R70G	SIDM00845	Burkitt's Lymphoma	GDSC	LMVHEE	LIG_APCC_ABBA_1	0.0556
p.H77Q	SIDM00113	Kidney Carcinoma	GDSC	LMVHEE	LIG_APCC_ABBA_1	0.25
p.H77Q	ACH-001208	Kidney Cancer	CCLE	LMVHEE	LIG_APCC_ABBA_1	0.25
p.H77Q	TK10	kidney	COSMIC	LMVHEE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQR1	Zinc finger protein 148	LIG_APCC_ABBA_1	80:85	LMVHEE	APC,CDC20,FZR1	0.9752	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons