DegronMD

Uniprot ID: Q9UQR1

Source protein: Zinc finger protein 148

Source gene: ZNF148

Class: DEG_SCF_FBW7_1

Location: 667:674

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 76.4

COIL: 0.8524

CONS_SCORE: 0.5714

DSS_SCORE: 0.5092

HELIX: 0.0251

FCONS_SCORE: 1.119

RIG_SCORE: 0.6869

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S665Y	TCGA-06-5416	GBM	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	0.7222
p.S665Y	TCGA-AJ-A5DW	UCEC	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	0.7222
p.S665Y	DO10880	GBM	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	0.7222
p.S665Y	DO50075	UCEC	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	0.7222
p.S683L	TCGA-85-A50M	LUSC	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	0.0833
p.S683L	DO45546	LUSC	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	0.0833
p.R668I	TCGA-AG-A002	READ	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	0.6991
p.H675Y	TCGA-DD-AAE0	LIHC	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	0.3056
p.H675Y	DO52253	LIHC	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	0.3056
p.P671L	TCGA-GN-A8LK	SKCM	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	0.7582
p.P671L	DO51259	SKCM	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	0.7582
p.G677V	TCGA-J9-A8CL	PRAD	TCGA	LRTTPDKS	DEG_SCF_FBW7_1	0.25
p.G677V	DO219265	PRAD	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	0.25
p.S674T	DO228253	MALY	ICGC	LRTTPDKS	DEG_SCF_FBW7_1	0.6005
p.R660Q	SIDM00118	Colorectal Carcinoma	GDSC	LRTTPDKS	DEG_SCF_FBW7_1	0.1389
p.R660Q	ACH-001081	Colon/Colorectal Cancer	CCLE	LRTTPDKS	DEG_SCF_FBW7_1	0.1389
p.R660Q	HCC2998	large_intestine	COSMIC	LRTTPDKS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQR1	Zinc finger protein 148	DEG_SCF_FBW7_1	667:674	LRTTPDKS	FBXW7	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons