DegronMD

Uniprot ID: Q9UQR1

Source protein: Zinc finger protein 148

Source gene: ZNF148

Class: DEG_SPOP_SBC_1

Location: 458:462

E3 ligase: SPOP

DEGRON score: 0.8177

ASA_SCORE: 87.74

COIL: 0.8766

CONS_SCORE: 0.5454

DSS_SCORE: 0.5934

HELIX: 0.0562

FCONS_SCORE: 0.8774

RIG_SCORE: 0.6571

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D465A	TCGA-B5-A1MR	UCEC	TCGA	VHSST	DEG_SPOP_SBC_1	0.25
p.D465A	DO41758	UCEC	ICGC	VHSST	DEG_SPOP_SBC_1	0.25
p.P457H	TCGA-B5-A3FC	UCEC	TCGA	VHSST	DEG_SPOP_SBC_1	0.3056
p.P457H	DO41871	UCEC	ICGC	VHSST	DEG_SPOP_SBC_1	0.3056
p.K472E	TCGA-B7-5818	STAD	TCGA	VHSST	DEG_SPOP_SBC_1	0.5
p.K472E	DO38883	STAD	ICGC	VHSST	DEG_SPOP_SBC_1	0.5
p.D465N	DO48414	BLCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.25
p.K456R	DO52139	PAEN	ICGC	VHSST	DEG_SPOP_SBC_1	0.7222
p.A467S	SIDM00523	Small Cell Lung Carcinoma	GDSC	VHSST	DEG_SPOP_SBC_1	0.1944
p.A467S	ACH-000698	Lung Cancer	CCLE	VHSST	DEG_SPOP_SBC_1	0.1944
p.A467S	DMS-53	lung	COSMIC	VHSST	DEG_SPOP_SBC_1	0.1944
p.M468V	SIDM00312	Plasma Cell Myeloma	GDSC	VHSST	DEG_SPOP_SBC_1	0.1667
p.M468V	ACH-000183	Myeloma	CCLE	VHSST	DEG_SPOP_SBC_1	0.1667
p.M468V	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	VHSST	DEG_SPOP_SBC_1	0.1667
p.Q469H	SIDM00528	Breast Carcinoma	GDSC	VHSST	DEG_SPOP_SBC_1	0.1389
p.Q469H	ACH-000934	Breast Cancer	CCLE	VHSST	DEG_SPOP_SBC_1	0.1389
p.Q469H	MDA-MB-361	breast	COSMIC	VHSST	DEG_SPOP_SBC_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons