DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 751:755

E3 ligase: SPOP

DEGRON score: 0.6465

ASA_SCORE: 90.2

COIL: 0.823

CONS_SCORE: 0

DSS_SCORE: 0.6514

HELIX: 0.0166

FCONS_SCORE: 0

RIG_SCORE: 0.6122

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T760K	DO225390	BRCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.1944
p.T755S	DO228483	BRCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.6005
p.T755S	DO229010	COCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.6005
p.T755S	DO229003	COCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.6005
p.T755S	DO229005	COCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.6005
p.T755S	DO234285	ESAD	ICGC	VHSST	DEG_SPOP_SBC_1	0.6005
p.T755S	DO52365	LUSC	ICGC	VHSST	DEG_SPOP_SBC_1	0.6005
p.M749T	DO229010	COCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.2778
p.M749T	DO229013	COCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.2778
p.M749T	DO229016	COCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.2778
p.M749T	DO229003	COCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.2778
p.M749T	DO229005	COCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.2778
p.S757L	DO220877	MELA	ICGC	VHSST	DEG_SPOP_SBC_1	0.2778
p.S757L	DO47268	SKCM	ICGC	VHSST	DEG_SPOP_SBC_1	0.2778
p.S757L	NCI-H835	lung	COSMIC	VHSST	DEG_SPOP_SBC_1	0.2778
p.V751I	DO232519	PBCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.7076
p.V751I	DO229542	UTCA	ICGC	VHSST	DEG_SPOP_SBC_1	0.7076
p.A747S	DO41199	UCEC	ICGC	VHSST	DEG_SPOP_SBC_1	0.2222
p.P746L	SIDM01313	Colorectal Carcinoma	GDSC	VHSST	DEG_SPOP_SBC_1	0.1944
p.T759R	SIDM01120	Other Solid Cancers	GDSC	VHSST	DEG_SPOP_SBC_1	0.2222
p.T759R	SK-MEL-2	skin	COSMIC	VHSST	DEG_SPOP_SBC_1	0.2222
p.S753N	ACH-000581	Gastric Cancer	CCLE	VHSST	DEG_SPOP_SBC_1	0.7069
p.S753N	ACH-000607	Rhabdoid	CCLE	VHSST	DEG_SPOP_SBC_1	0.7069
p.S753N	KYM-1	soft_tissue	COSMIC	VHSST	DEG_SPOP_SBC_1	0.7069
p.S753N	NCI-SNU-16	stomach	COSMIC	VHSST	DEG_SPOP_SBC_1	0.7069
p.S753N	SAT	upper_aerodigestive_tract	COSMIC	VHSST	DEG_SPOP_SBC_1	0.7069
p.H759Y	ACH-001970	Metastasis	CCLE	VHSST	DEG_SPOP_SBC_1	0.2222
p.A741T	SNU-175	large_intestine	COSMIC	VHSST	DEG_SPOP_SBC_1	0.0556
p.M749I	SBC-1	lung	COSMIC	VHSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCD6	Protein TANC2	DEG_SPOP_SBC_1	1622:1626	VHSST	SPOP	0.9669	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	751:755	VHSST	SPOP	0.6465	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4446:4450	VHSST	SPOP	0.7686	More...
Q9UQR1	Zinc finger protein 148	DEG_SPOP_SBC_1	458:462	VHSST	SPOP	0.8177	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VHSST

Degron related mutations and impact score

Drug responses associated with MUC12 mutations

All proteins holding degron of VHSST