DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VHSST
Uniprot ID:
Q9UKN1
Source protein:
Mucin-12
Source gene:
MUC12
Class:
DEG_SPOP_SBC_1
Location:
751:755
E3 ligase:
SPOP
DEGRON score:
0.6465
ASA_SCORE:
90.2
COIL:
0.823
CONS_SCORE:
0
DSS_SCORE:
0.6514
HELIX:
0.0166
FCONS_SCORE:
0
RIG_SCORE:
0.6122
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V751I
DO232519
PBCA
ICGC
VHSST
DEG_SPOP_SBC_1
0.7076
p.V751I
DO229542
UTCA
ICGC
VHSST
DEG_SPOP_SBC_1
0.7076
p.S753N
ACH-000581
Gastric Cancer
CCLE
VHSST
DEG_SPOP_SBC_1
0.7069
p.S753N
ACH-000607
Rhabdoid
CCLE
VHSST
DEG_SPOP_SBC_1
0.7069
p.S753N
KYM-1
soft_tissue
COSMIC
VHSST
DEG_SPOP_SBC_1
0.7069
p.S753N
NCI-SNU-16
stomach
COSMIC
VHSST
DEG_SPOP_SBC_1
0.7069
p.S753N
SAT
upper_aerodigestive_tract
COSMIC
VHSST
DEG_SPOP_SBC_1
0.7069
p.T755S
DO228483
BRCA
ICGC
VHSST
DEG_SPOP_SBC_1
0.6005
p.T755S
DO229010
COCA
ICGC
VHSST
DEG_SPOP_SBC_1
0.6005
p.T755S
DO229003
COCA
ICGC
VHSST
DEG_SPOP_SBC_1
0.6005
p.T755S
DO229005
COCA
ICGC
VHSST
DEG_SPOP_SBC_1
0.6005
p.T755S
DO234285
ESAD
ICGC
VHSST
DEG_SPOP_SBC_1
0.6005
p.T755S
DO52365
LUSC
ICGC
VHSST
DEG_SPOP_SBC_1
0.6005
p.M749T
DO229010
COCA
ICGC
VHSST
DEG_SPOP_SBC_1
0.2778
p.M749T
DO229013
COCA
ICGC
VHSST
DEG_SPOP_SBC_1
0.2778
p.M749T
DO229016
COCA
ICGC
VHSST
DEG_SPOP_SBC_1
0.2778
p.M749T
DO229003
COCA
ICGC
VHSST
DEG_SPOP_SBC_1
0.2778
p.M749T
DO229005
COCA
ICGC
VHSST
DEG_SPOP_SBC_1
0.2778
p.S757L
DO220877
MELA
ICGC
VHSST
DEG_SPOP_SBC_1
0.2778
p.S757L
DO47268
SKCM
ICGC
VHSST
DEG_SPOP_SBC_1
0.2778
p.S757L
NCI-H835
lung
COSMIC
VHSST
DEG_SPOP_SBC_1
0.2778
p.M749I
SBC-1
lung
COSMIC
VHSST
DEG_SPOP_SBC_1
0.2778
p.A747S
DO41199
UCEC
ICGC
VHSST
DEG_SPOP_SBC_1
0.2222
p.T759R
SIDM01120
Other Solid Cancers
GDSC
VHSST
DEG_SPOP_SBC_1
0.2222
p.T759R
SK-MEL-2
skin
COSMIC
VHSST
DEG_SPOP_SBC_1
0.2222
Showing 1 to 25 of 29 entries
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Drug responses associated with MUC12 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of VHSST
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
751:755
VHSST
SPOP
0.6465
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
4446:4450
VHSST
SPOP
0.7686
More...
Q9HCD6
Protein TANC2
DEG_SPOP_SBC_1
1622:1626
VHSST
SPOP
0.9669
More...
Q9UQR1
Zinc finger protein 148
DEG_SPOP_SBC_1
458:462
VHSST
SPOP
0.8177
More...
Showing 1 to 4 of 4 entries
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