DegronMD

Uniprot ID: Q5JV73

Source protein: FERM and PDZ domain-containing protein 3

Source gene: FRMPD3

Class: DEG_SPOP_SBC_1

Location: 949:953

E3 ligase: SPOP

DEGRON score: 0.9369

ASA_SCORE: 77.22

COIL: 0.903

CONS_SCORE: 0.429

DSS_SCORE: 0.4965

HELIX: 0.0644

FCONS_SCORE: 1.2443

RIG_SCORE: 0.6743

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A949V	TCGA-G4-6628	COAD	TCGA	AATSS	DEG_SPOP_SBC_1	0.5825
p.A949V	DO10132	COAD	ICGC	AATSS	DEG_SPOP_SBC_1	0.5825
p.R948G	ACH-000950	Colon/Colorectal Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	0.3056
p.S955G	DO230449	UTCA	ICGC	AATSS	DEG_SPOP_SBC_1	0.2778
p.E944K	TCGA-CN-A6V6	HNSC	TCGA	AATSS	DEG_SPOP_SBC_1	0.1944
p.E944K	DO218995	HNSC	ICGC	AATSS	DEG_SPOP_SBC_1	0.1944
p.A941S	DO50889	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	0.1111
p.R940K	DO50970	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 8 of 8 entries

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Drug responses associated with FRMPD3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AATSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L2J0	7SK snRNA methylphosphate capping enzyme	DEG_SPOP_SBC_1	73:77	AATSS	SPOP	0.9873	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_SPOP_SBC_1	1272:1276	AATSS	SPOP	0.8855	More...
Q5JV73	FERM and PDZ domain-containing protein 3	DEG_SPOP_SBC_1	949:953	AATSS	SPOP	0.9369	More...
Q5HY92	Fidgetin	DEG_SPOP_SBC_1	449:453	AATSS	SPOP	0.623	More...
Q8TC56	Golgi associated RAB2 interactor protein 3	DEG_SPOP_SBC_1	225:229	AATSS	SPOP	0.8742	More...
Q75QN2	Integrator complex subunit 8	DEG_SPOP_SBC_1	10:14	AATSS	SPOP	0.8854	More...
Q15345	Leucine-rich repeat-containing protein 41	DEG_SPOP_SBC_1	362:366	AATSS	SPOP	0.9096	More...
Q9UNZ5	Leydig cell tumor 10 kDa protein homolog	DEG_SPOP_SBC_1	91:95	AATSS	SPOP	0.9522	More...
Q99683	Mitogen-activated protein kinase kinase kinase 5	DEG_SPOP_SBC_1	69:73	AATSS	SPOP	0.9979	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3473:3477	AATSS	SPOP	0.9561	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3906:3910	AATSS	SPOP	0.9778	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4212:4216	AATSS	SPOP	0.9754	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2727:2731	AATSS	SPOP	0.9343	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3427:3431	AATSS	SPOP	0.9499	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3984:3988	AATSS	SPOP	0.9705	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4717:4721	AATSS	SPOP	0.9583	More...
P30414	NK-tumor recognition protein	DEG_SPOP_SBC_1	1240:1244	AATSS	SPOP	0.574	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1067:1071	AATSS	SPOP	0.625	More...
P51575	P2X purinoceptor 1	DEG_SPOP_SBC_1	384:388	AATSS	SPOP	0.9498	More...
Q9Y6C5	Protein patched homolog 2	DEG_SPOP_SBC_1	1186:1190	AATSS	SPOP	0.9776	More...
Q96M27	Protein PRRC1	DEG_SPOP_SBC_1	35:39	AATSS	SPOP	0.8538	More...
Q9C0D5	Protein TANC1	DEG_SPOP_SBC_1	315:319	AATSS	SPOP	0.9995	More...
Q9HCD6	Protein TANC2	DEG_SPOP_SBC_1	270:274	AATSS	SPOP	0.7398	More...
Q08188	Protein-glutamine gamma-glutamyltransferase E	DEG_SPOP_SBC_1	467:471	AATSS	SPOP	0.503	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	652:656	AATSS	SPOP	0.8671	More...

Showing 1 to 25 of 32 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AATSS

Degron related mutations and impact score

Drug responses associated with FRMPD3 mutations

All proteins holding degron of AATSS