DegronMD

Uniprot ID: Q9UNY4

Source protein: Transcription termination factor 2

Source gene: TTF2

Class: DEG_APCC_KENBOX_2

Location: 380:384

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9914

ASA_SCORE: 87.74

COIL: 0.5614

CONS_SCORE: 0.261

DSS_SCORE: 0.4663

HELIX: 0.4106

FCONS_SCORE: 1.0142

RIG_SCORE: 0.7758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T380M	TCGA-A5-A0G2	UCEC	TCGA	TKENL	DEG_APCC_KENBOX_2	0.7423
p.T380M	DO229051	LICA	ICGC	TKENL	DEG_APCC_KENBOX_2	0.7423
p.T380M	DO41235	UCEC	ICGC	TKENL	DEG_APCC_KENBOX_2	0.7423
p.T380R	TCGA-D3-A2JL	SKCM	TCGA	TKENL	DEG_APCC_KENBOX_2	0.7876
p.T380R	DO47278	SKCM	ICGC	TKENL	DEG_APCC_KENBOX_2	0.7876
p.L376M	TCGA-FI-A2D5	UCEC	TCGA	TKENL	DEG_APCC_KENBOX_2	0.2222
p.L376M	DO48440	BLCA	ICGC	TKENL	DEG_APCC_KENBOX_2	0.2222
p.L376M	DO41331	UCEC	ICGC	TKENL	DEG_APCC_KENBOX_2	0.2222
p.K381N	TCGA-FS-A1ZG	SKCM	TCGA	TKENL	DEG_APCC_KENBOX_2	0.6918
p.K381N	DO37523	SKCM	ICGC	TKENL	DEG_APCC_KENBOX_2	0.6918
p.L384P	DO228949	LICA	ICGC	TKENL	DEG_APCC_KENBOX_2	0.6471
p.R389Q	DO232761	PBCA	ICGC	TKENL	DEG_APCC_KENBOX_2	0.1944
p.N383T	ACH-000955	Colon/Colorectal Cancer	CCLE	TKENL	DEG_APCC_KENBOX_2	0.7055
p.N383T	SNU-407	large_intestine	COSMIC	TKENL	DEG_APCC_KENBOX_2	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53671	LIM domain kinase 2	DEG_APCC_KENBOX_2	271:275	TKENL	APC,CDC20,FZR1	0.5984	More...
Q5VWN6	Protein TASOR 2	DEG_APCC_KENBOX_2	1763:1767	TKENL	APC,CDC20,FZR1	0.5719	More...
Q9UNY4	Transcription termination factor 2	DEG_APCC_KENBOX_2	380:384	TKENL	APC,CDC20,FZR1	0.9914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons