DegronMD - P53671(LIMK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E280Q	TCGA-60-2720	LUSC	TCGA	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.1944
p.E200D	TCGA-A6-2686	COAD	TCGA	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.1389
p.E200D	DO7828	COAD	ICGC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.1389
p.G274D	TCGA-AP-A0LP	UCEC	TCGA	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation altering degron motif	0.7198
p.R265C	TCGA-AP-A0LT	UCEC	TCGA	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.1667
p.R265C	TCGA-VQ-A8PT	STAD	TCGA	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.1667
p.R265H	TCGA-B5-A11Y	UCEC	TCGA	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.1667
p.R222C	TCGA-B5-A3FC	UCEC	TCGA	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.1111
p.R222C	DO41871	UCEC	ICGC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.1111
p.R222C	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.1111
p.R222C	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.1111
p.T206M	TCGA-D1-A17B	UCEC	TCGA	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.3056
p.T206M	DO43017	UCEC	ICGC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.3056
p.R261C	TCGA-D1-A17D	UCEC	TCGA	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.0556
p.R261C	DO41746	UCEC	ICGC	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.0556
p.S270F	TCGA-D3-A8GR	SKCM	TCGA	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.3056
p.E198D	TCGA-EI-6507	READ	TCGA	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.0833
p.E198D	DO36675	READ	ICGC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.0833
p.R222H	TCGA-EO-A22U	UCEC	TCGA	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.1111
p.R222H	DO43755	UCEC	ICGC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.1111
p.S262F	TCGA-YD-A89C	SKCM	TCGA	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.0833
p.S262F	DO219501	SKCM	ICGC	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.0833
p.D216N	DO223703	COAD	ICGC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.2778
p.R222L	DO228971	LICA	ICGC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.1111
p.D217Y	DO229006	LICA	ICGC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.25
p.D278H	DO52291	LIHC	ICGC	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation blocking phosphorylation signal	0.6944
p.H209R	DO23525	LIRI	ICGC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation altering degron motif	0.8244
p.S285F	DO222494	MELA	ICGC	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.0556
p.S285F	DO51301	SKCM	ICGC	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.0556
p.T209R	DO222632	MELA	ICGC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation altering degron motif	0.7876
p.A268V	DO46342	OV	ICGC	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.25
p.Y277H	DO46657	PAAD	ICGC	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.2778
p.L212V	DO49136	PACA	ICGC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation altering degron motif	0.6765
p.H209N	DO36228	PRAD	ICGC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation altering degron motif	0.7423
p.P269H	DO37447	SKCM	ICGC	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.2778
p.P264H	DO37951	SKCM	ICGC	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.1389
p.R203H	ACH-000360	Colon/Colorectal Cancer	CCLE	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.2222
p.R203H	NCI-H508	large intestine	COSMIC	INGTPVRT	DEG_SCF_FBW7_1	207:214	Mutation rewiring degron network	0.2222
p.I268V	FU97	stomach	COSMIC	TKENL	DEG_APCC_KENBOX_2	271:275	Mutation rewiring degron network	0.25

Kaplan plot for LIMK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LIMK2

UniProt ID: P53671

Entrez ID: 3985

Protein name: LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LIMK2 in