DegronMD

Uniprot ID: P53671

Source protein: LIM domain kinase 2

Source gene: LIMK2

Class: DEG_SCF_FBW7_1

Location: 207:214

E3 ligase: FBXW7

DEGRON score: 0.9887

ASA_SCORE: 76.2375

COIL: 0.7614

CONS_SCORE: 0.5062

DSS_SCORE: 0.3629

HELIX: 0.035

FCONS_SCORE: 1.072

RIG_SCORE: 0.7473

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E200D	TCGA-A6-2686	COAD	TCGA	INGTPVRT	DEG_SCF_FBW7_1	0.1389
p.E200D	DO7828	COAD	ICGC	INGTPVRT	DEG_SCF_FBW7_1	0.1389
p.R222C	TCGA-B5-A3FC	UCEC	TCGA	INGTPVRT	DEG_SCF_FBW7_1	0.1111
p.R222C	DO41871	UCEC	ICGC	INGTPVRT	DEG_SCF_FBW7_1	0.1111
p.R222C	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	INGTPVRT	DEG_SCF_FBW7_1	0.1111
p.R222C	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	INGTPVRT	DEG_SCF_FBW7_1	0.1111
p.T206M	TCGA-D1-A17B	UCEC	TCGA	INGTPVRT	DEG_SCF_FBW7_1	0.3056
p.T206M	DO43017	UCEC	ICGC	INGTPVRT	DEG_SCF_FBW7_1	0.3056
p.E198D	TCGA-EI-6507	READ	TCGA	INGTPVRT	DEG_SCF_FBW7_1	0.0833
p.E198D	DO36675	READ	ICGC	INGTPVRT	DEG_SCF_FBW7_1	0.0833
p.R222H	TCGA-EO-A22U	UCEC	TCGA	INGTPVRT	DEG_SCF_FBW7_1	0.1111
p.R222H	DO43755	UCEC	ICGC	INGTPVRT	DEG_SCF_FBW7_1	0.1111
p.D216N	DO223703	COAD	ICGC	INGTPVRT	DEG_SCF_FBW7_1	0.2778
p.R222L	DO228971	LICA	ICGC	INGTPVRT	DEG_SCF_FBW7_1	0.1111
p.D217Y	DO229006	LICA	ICGC	INGTPVRT	DEG_SCF_FBW7_1	0.25
p.H209R	DO23525	LIRI	ICGC	INGTPVRT	DEG_SCF_FBW7_1	0.8244
p.T209R	DO222632	MELA	ICGC	INGTPVRT	DEG_SCF_FBW7_1	0.7876
p.L212V	DO49136	PACA	ICGC	INGTPVRT	DEG_SCF_FBW7_1	0.6765
p.H209N	DO36228	PRAD	ICGC	INGTPVRT	DEG_SCF_FBW7_1	0.7423
p.R203H	ACH-000360	Colon/Colorectal Cancer	CCLE	INGTPVRT	DEG_SCF_FBW7_1	0.2222
p.R203H	NCI-H508	large_intestine	COSMIC	INGTPVRT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53671	LIM domain kinase 2	DEG_SCF_FBW7_1	207:214	INGTPVRT	FBXW7	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons