DegronMD

Uniprot ID: P53671

Source protein: LIM domain kinase 2

Source gene: LIMK2

Class: DEG_APCC_KENBOX_2

Location: 271:275

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5984

ASA_SCORE: 94.66

COIL: 0.5874

CONS_SCORE: 0.4217

DSS_SCORE: 0.6021

HELIX: 0.3962

FCONS_SCORE: 0.9442

RIG_SCORE: 0.7165

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E280Q	TCGA-60-2720	LUSC	TCGA	TKENL	DEG_APCC_KENBOX_2	0.1944
p.G274D	TCGA-AP-A0LP	UCEC	TCGA	TKENL	DEG_APCC_KENBOX_2	0.7198
p.R265C	TCGA-AP-A0LT	UCEC	TCGA	TKENL	DEG_APCC_KENBOX_2	0.1667
p.R265C	TCGA-VQ-A8PT	STAD	TCGA	TKENL	DEG_APCC_KENBOX_2	0.1667
p.R265H	TCGA-B5-A11Y	UCEC	TCGA	TKENL	DEG_APCC_KENBOX_2	0.1667
p.R261C	TCGA-D1-A17D	UCEC	TCGA	TKENL	DEG_APCC_KENBOX_2	0.0556
p.R261C	DO41746	UCEC	ICGC	TKENL	DEG_APCC_KENBOX_2	0.0556
p.S270F	TCGA-D3-A8GR	SKCM	TCGA	TKENL	DEG_APCC_KENBOX_2	0.3056
p.S262F	TCGA-YD-A89C	SKCM	TCGA	TKENL	DEG_APCC_KENBOX_2	0.0833
p.S262F	DO219501	SKCM	ICGC	TKENL	DEG_APCC_KENBOX_2	0.0833
p.D278H	DO52291	LIHC	ICGC	TKENL	DEG_APCC_KENBOX_2	0.6944
p.S285F	DO222494	MELA	ICGC	TKENL	DEG_APCC_KENBOX_2	0.0556
p.S285F	DO51301	SKCM	ICGC	TKENL	DEG_APCC_KENBOX_2	0.0556
p.A268V	DO46342	OV	ICGC	TKENL	DEG_APCC_KENBOX_2	0.25
p.Y277H	DO46657	PAAD	ICGC	TKENL	DEG_APCC_KENBOX_2	0.2778
p.P269H	DO37447	SKCM	ICGC	TKENL	DEG_APCC_KENBOX_2	0.2778
p.P264H	DO37951	SKCM	ICGC	TKENL	DEG_APCC_KENBOX_2	0.1389
p.I268V	FU97	stomach	COSMIC	TKENL	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53671	LIM domain kinase 2	DEG_APCC_KENBOX_2	271:275	TKENL	APC,CDC20,FZR1	0.5984	More...
Q5VWN6	Protein TASOR 2	DEG_APCC_KENBOX_2	1763:1767	TKENL	APC,CDC20,FZR1	0.5719	More...
Q9UNY4	Transcription termination factor 2	DEG_APCC_KENBOX_2	380:384	TKENL	APC,CDC20,FZR1	0.9914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons