DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
TKENL
Uniprot ID:
Q5VWN6
Source protein:
Protein TASOR 2
Source gene:
TASOR2
Class:
DEG_APCC_KENBOX_2
Location:
1763:1767
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5719
ASA_SCORE:
98.64
COIL:
0.638
CONS_SCORE:
0.3462
DSS_SCORE:
0.4254
HELIX:
0.3226
FCONS_SCORE:
0.7402
RIG_SCORE:
0.7788
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TASOR2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TKENL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P53671
LIM domain kinase 2
DEG_APCC_KENBOX_2
271:275
TKENL
APC,CDC20,FZR1
0.5984
More...
Q5VWN6
Protein TASOR 2
DEG_APCC_KENBOX_2
1763:1767
TKENL
APC,CDC20,FZR1
0.5719
More...
Q9UNY4
Transcription termination factor 2
DEG_APCC_KENBOX_2
380:384
TKENL
APC,CDC20,FZR1
0.9914
More...