DegronMD

Uniprot ID: Q14669

Source protein: E3 ubiquitin-protein ligase TRIP12

Source gene: TRIP12

Class: DEG_SPOP_SBC_1

Location: 199:203

E3 ligase: SPOP

DEGRON score: 0.9879

ASA_SCORE: 91.52

COIL: 0.945

CONS_SCORE: 0.2958

DSS_SCORE: 0.4263

HELIX: 0.0406

FCONS_SCORE: 0.9249

RIG_SCORE: 0.5782

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H203Y	DO223907	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	0.7229
p.M201L	D-336MG	central_nervous_system	COSMIC	AASTS	DEG_SPOP_SBC_1	0.711
p.S204F	TCGA-77-8146	LUSC	TCGA	AASTS	DEG_SPOP_SBC_1	0.3056
p.G204R	DO233245	GACA	ICGC	AASTS	DEG_SPOP_SBC_1	0.3056
p.S198A	HuO-3N1	bone	COSMIC	AASTS	DEG_SPOP_SBC_1	0.3056
p.S205P	TCGA-CG-4442	STAD	TCGA	AASTS	DEG_SPOP_SBC_1	0.2778
p.S197Y	DO43907	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	0.2778
p.S197T	ACH-000593	Bladder Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.2778
p.S196N	DO41903	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	0.25
p.A207T	ACH-000330	Breast Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.2222
p.A207T	EFM-19	breast	COSMIC	AASTS	DEG_SPOP_SBC_1	0.2222
p.R193K	DO230326	COCA	ICGC	AASTS	DEG_SPOP_SBC_1	0.1667
p.R193K	DO219879	SKCA	ICGC	AASTS	DEG_SPOP_SBC_1	0.1667
p.R193K	DO218858	SKCA	ICGC	AASTS	DEG_SPOP_SBC_1	0.1667
p.L191F	ACH-000779	Lung Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.1111
p.K190R	DO8938	COAD	ICGC	AASTS	DEG_SPOP_SBC_1	0.0833
p.T190M	DO42384	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	0.0833
p.Q189H	DO447	BLCA	ICGC	AASTS	DEG_SPOP_SBC_1	0.0556
p.Q189L	DO22966	LIHC	ICGC	AASTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 19 of 19 entries

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Drug responses associated with TRIP12 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AASTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	1155:1159	AASTS	SPOP	0.7759	More...
O95081	Arf-GAP domain and FG repeat-containing protein 2	DEG_SPOP_SBC_1	189:193	AASTS	SPOP	0.9166	More...
Q9P2R6	Arginine-glutamic acid dipeptide repeats protein	DEG_SPOP_SBC_1	616:620	AASTS	SPOP	0.997	More...
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	122:126	AASTS	SPOP	0.9939	More...
Q9UJX2	Cell division cycle protein 23 homolog	DEG_SPOP_SBC_1	2:6	AASTS	SPOP	0.5243	More...
Q13049	E3 ubiquitin-protein ligase TRIM32	DEG_SPOP_SBC_1	315:319	AASTS	SPOP	0.925	More...
Q14669	E3 ubiquitin-protein ligase TRIP12	DEG_SPOP_SBC_1	199:203	AASTS	SPOP	0.9879	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SPOP_SBC_1	14:18	AASTS	SPOP	0.9981	More...
Q8TC56	Golgi associated RAB2 interactor protein 3	DEG_SPOP_SBC_1	348:352	AASTS	SPOP	0.9521	More...
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_SPOP_SBC_1	363:367	AASTS	SPOP	0.8439	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	21:25	AASTS	SPOP	0.9238	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2095:2099	AASTS	SPOP	0.5839	More...
O75113	NEDD4-binding protein 1	DEG_SPOP_SBC_1	804:808	AASTS	SPOP	0.9913	More...
O15504	Nucleoporin NUP42	DEG_SPOP_SBC_1	274:278	AASTS	SPOP	0.5936	More...
O95259	Potassium voltage-gated channel subfamily H member 1	DEG_SPOP_SBC_1	802:806	AASTS	SPOP	0.8742	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	414:418	AASTS	SPOP	0.97	More...
Q2KHT3	Protein CLEC16A	DEG_SPOP_SBC_1	450:454	AASTS	SPOP	0.6135	More...
A6NL46	Putative UPF0607 protein ENSP00000332738	DEG_SPOP_SBC_1	108:112	AASTS	SPOP	0.9403	More...
A8MUA0	Putative UPF0607 protein ENSP00000381514	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.7629	More...
A8MV72	Putative UPF0607 protein ENSP00000382826	DEG_SPOP_SBC_1	79:83	AASTS	SPOP	0.8388	More...
A8MX80	Putative UPF0607 protein ENSP00000383144	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.6735	More...
Q8N9G6	Putative UPF0607 protein FLJ37424	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.878	More...
Q5PR19	Putative UPF0607 protein LOC392364	DEG_SPOP_SBC_1	146:150	AASTS	SPOP	0.6539	More...
Q9BWF3	RNA-binding protein 4	DEG_SPOP_SBC_1	298:302	AASTS	SPOP	0.9032	More...
O95721	Synaptosomal-associated protein 29	DEG_SPOP_SBC_1	57:61	AASTS	SPOP	0.8495	More...

Showing 1 to 25 of 28 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASTS

Degron related mutations and impact score

Drug responses associated with TRIP12 mutations

All proteins holding degron of AASTS