DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
AASTS
Uniprot ID:
O95259
Source protein:
Potassium voltage-gated channel subfamily H member 1
Source gene:
KCNH1
Class:
DEG_SPOP_SBC_1
Location:
802:806
E3 ligase:
SPOP
DEGRON score:
0.8742
ASA_SCORE:
71.34
COIL:
0.8232
CONS_SCORE:
0.2944
DSS_SCORE:
0.5057
HELIX:
0.1618
FCONS_SCORE:
0.9788
RIG_SCORE:
0.6618
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V798I
TCGA-50-7109
LUAD
TCGA
AASTS
DEG_SPOP_SBC_1
0.2222
p.V798I
TCGA-CK-4951
COAD
TCGA
AASTS
DEG_SPOP_SBC_1
0.2222
p.V798I
TCGA-DM-A0XD
COAD
TCGA
AASTS
DEG_SPOP_SBC_1
0.2222
p.V798I
DO10582
COAD
ICGC
AASTS
DEG_SPOP_SBC_1
0.2222
p.V798I
DO10228
COAD
ICGC
AASTS
DEG_SPOP_SBC_1
0.2222
p.V798I
DO24487
LUAD
ICGC
AASTS
DEG_SPOP_SBC_1
0.2222
p.V798I
SIDM01511
Gastric Carcinoma
GDSC
AASTS
DEG_SPOP_SBC_1
0.2222
p.V798I
ACH-000746
Gastric Cancer
CCLE
AASTS
DEG_SPOP_SBC_1
0.2222
p.P797H
TCGA-60-2714
LUSC
TCGA
AASTS
DEG_SPOP_SBC_1
0.1944
p.P797H
DO26530
LUSC
ICGC
AASTS
DEG_SPOP_SBC_1
0.1944
p.F800L
TCGA-A7-A56D
BRCA
TCGA
AASTS
DEG_SPOP_SBC_1
0.2778
p.F800L
DO44165
BRCA
ICGC
AASTS
DEG_SPOP_SBC_1
0.2778
p.T796M
TCGA-B5-A0K9
UCEC
TCGA
AASTS
DEG_SPOP_SBC_1
0.1667
p.T796M
DO42097
UCEC
ICGC
AASTS
DEG_SPOP_SBC_1
0.1667
p.S804F
TCGA-EB-A5UN
SKCM
TCGA
AASTS
DEG_SPOP_SBC_1
0.7982
p.S804F
TCGA-GN-A266
SKCM
TCGA
AASTS
DEG_SPOP_SBC_1
0.7982
p.S804F
DO47267
SKCM
ICGC
AASTS
DEG_SPOP_SBC_1
0.7982
p.S804F
DO37432
SKCM
ICGC
AASTS
DEG_SPOP_SBC_1
0.7982
p.H811N
TCGA-EE-A20F
SKCM
TCGA
AASTS
DEG_SPOP_SBC_1
0.1944
p.H811N
DO37961
SKCM
ICGC
AASTS
DEG_SPOP_SBC_1
0.1944
p.S799P
TCGA-FP-A9TM
STAD
TCGA
AASTS
DEG_SPOP_SBC_1
0.25
p.S799P
DO222332
STAD
ICGC
AASTS
DEG_SPOP_SBC_1
0.25
p.S804P
TCGA-O2-A52Q
LUSC
TCGA
AASTS
DEG_SPOP_SBC_1
0.6752
p.S804P
DO219219
LUSC
ICGC
AASTS
DEG_SPOP_SBC_1
0.6752
p.D810Y
DO223142
ESCA
ICGC
AASTS
DEG_SPOP_SBC_1
0.2222
p.A816V
DO233898
GACA
ICGC
AASTS
DEG_SPOP_SBC_1
0.0556
p.A812T
DO228258
MALY
ICGC
AASTS
DEG_SPOP_SBC_1
0.1667
p.A812T
SIDM01045
Endometrial Carcinoma
GDSC
AASTS
DEG_SPOP_SBC_1
0.1667
p.A812T
SIDM00217
Colorectal Carcinoma
GDSC
AASTS
DEG_SPOP_SBC_1
0.1667
p.A812T
SNU-1040
large_intestine
COSMIC
AASTS
DEG_SPOP_SBC_1
0.1667
p.A812T
EN
endometrium
COSMIC
AASTS
DEG_SPOP_SBC_1
0.1667
p.A816S
SIDM00217
Colorectal Carcinoma
GDSC
AASTS
DEG_SPOP_SBC_1
0.0556
p.A816S
ACH-000999
Colon/Colorectal Cancer
CCLE
AASTS
DEG_SPOP_SBC_1
0.0556
p.A816S
SNU-1040
large_intestine
COSMIC
AASTS
DEG_SPOP_SBC_1
0.0556
p.Q815H
SIDM01608
Endometrial Carcinoma
GDSC
AASTS
DEG_SPOP_SBC_1
0.0833
p.Q815H
ACH-000990
Endometrial/Uterine Cancer
CCLE
AASTS
DEG_SPOP_SBC_1
0.0833
p.G801E
KYSE-220
oesophagus
COSMIC
AASTS
DEG_SPOP_SBC_1
0.3056
Drug responses associated with KCNH1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AASTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15391
Transcription factor YY2
DEG_SPOP_SBC_1
127:131
AASTS
SPOP
0.8632
More...
O15504
Nucleoporin NUP42
DEG_SPOP_SBC_1
274:278
AASTS
SPOP
0.5936
More...
O43670
BUB3-interacting and GLEBS motif-containing protein ZNF207
DEG_SPOP_SBC_1
122:126
AASTS
SPOP
0.9939
More...
O75113
NEDD4-binding protein 1
DEG_SPOP_SBC_1
804:808
AASTS
SPOP
0.9913
More...
O95259
Potassium voltage-gated channel subfamily H member 1
DEG_SPOP_SBC_1
802:806
AASTS
SPOP
0.8742
More...
O95721
Synaptosomal-associated protein 29
DEG_SPOP_SBC_1
57:61
AASTS
SPOP
0.8495
More...
P11473
Vitamin D3 receptor
DEG_SPOP_SBC_1
5:9
AASTS
SPOP
0.7318
More...
P18827
Syndecan-1
DEG_SPOP_SBC_1
87:91
AASTS
SPOP
0.9596
More...
P46821
Microtubule-associated protein 1B
DEG_SPOP_SBC_1
21:25
AASTS
SPOP
0.9238
More...
Q13049
E3 ubiquitin-protein ligase TRIM32
DEG_SPOP_SBC_1
315:319
AASTS
SPOP
0.925
More...
Q14669
E3 ubiquitin-protein ligase TRIP12
DEG_SPOP_SBC_1
199:203
AASTS
SPOP
0.9879
More...
Q2KHT3
Protein CLEC16A
DEG_SPOP_SBC_1
450:454
AASTS
SPOP
0.6135
More...
Q6VMQ6
Activating transcription factor 7-interacting protein 1
DEG_SPOP_SBC_1
1155:1159
AASTS
SPOP
0.7759
More...
Q8IYG6
Leucine-rich repeat-containing protein 56
DEG_SPOP_SBC_1
363:367
AASTS
SPOP
0.8439
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
2095:2099
AASTS
SPOP
0.5839
More...
Q9BWF3
RNA-binding protein 4
DEG_SPOP_SBC_1
298:302
AASTS
SPOP
0.9032
More...
Q9HC35
Echinoderm microtubule-associated protein-like 4
DEG_SPOP_SBC_1
14:18
AASTS
SPOP
0.9981
More...
Q9P2R6
Arginine-glutamic acid dipeptide repeats protein
DEG_SPOP_SBC_1
616:620
AASTS
SPOP
0.997
More...
Q9UJX2
Cell division cycle protein 23 homolog
DEG_SPOP_SBC_1
2:6
AASTS
SPOP
0.5243
More...
O95081
Arf-GAP domain and FG repeat-containing protein 2
DEG_SPOP_SBC_1
189:193
AASTS
SPOP
0.9166
More...
Q8TC56
Golgi associated RAB2 interactor protein 3
DEG_SPOP_SBC_1
348:352
AASTS
SPOP
0.9521
More...
A6NL46
Putative UPF0607 protein ENSP00000332738
DEG_SPOP_SBC_1
108:112
AASTS
SPOP
0.9403
More...
A8MUA0
Putative UPF0607 protein ENSP00000381514
DEG_SPOP_SBC_1
109:113
AASTS
SPOP
0.7629
More...
A8MV72
Putative UPF0607 protein ENSP00000382826
DEG_SPOP_SBC_1
79:83
AASTS
SPOP
0.8388
More...
A8MX80
Putative UPF0607 protein ENSP00000383144
DEG_SPOP_SBC_1
109:113
AASTS
SPOP
0.6735
More...
Q5PR19
Putative UPF0607 protein LOC392364
DEG_SPOP_SBC_1
146:150
AASTS
SPOP
0.6539
More...
Q86XN7
Proline and serine-rich protein 1
DEG_SPOP_SBC_1
414:418
AASTS
SPOP
0.97
More...
Q8N9G6
Putative UPF0607 protein FLJ37424
DEG_SPOP_SBC_1
109:113
AASTS
SPOP
0.878
More...