DegronMD - O95259(KCNH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S887R	TCGA-15-1446	GBM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation altering degron motif	0.7427
p.S887R	DO12490	GBM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation altering degron motif	0.7427
p.V798I	TCGA-50-7109	LUAD	TCGA	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.2222
p.V798I	TCGA-CK-4951	COAD	TCGA	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.2222
p.V798I	TCGA-DM-A0XD	COAD	TCGA	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.2222
p.V798I	DO10582	COAD	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.2222
p.V798I	DO10228	COAD	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.2222
p.V798I	DO24487	LUAD	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.2222
p.V798I	SIDM01511	Gastric Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.2222
p.V798I	ACH-000746	Gastric Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.2222
p.P797H	TCGA-60-2714	LUSC	TCGA	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1944
p.P797H	DO26530	LUSC	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1944
p.F800L	TCGA-A7-A56D	BRCA	TCGA	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.2778
p.F800L	DO44165	BRCA	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.2778
p.A897T	TCGA-AX-A1C5	UCEC	TCGA	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.0556
p.A897T	DO41422	UCEC	ICGC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.0556
p.S879L	TCGA-AZ-4315	COAD	TCGA	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.2778
p.S879L	DO8842	COAD	ICGC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.2778
p.T796M	TCGA-B5-A0K9	UCEC	TCGA	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1667
p.T796M	DO42097	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1667
p.K876N	TCGA-DU-7013	LGG	TCGA	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation substituting flanking lysine	0.3056
p.K876N	DO22217	LGG	ICGC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation substituting flanking lysine	0.3056
p.S804F	TCGA-EB-A5UN	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.7982
p.S804F	TCGA-GN-A266	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.7982
p.S804F	DO47267	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.7982
p.S804F	DO37432	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.7982
p.H811N	TCGA-EE-A20F	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1944
p.H811N	DO37961	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1944
p.S799P	TCGA-FP-A9TM	STAD	TCGA	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.25
p.S799P	DO222332	STAD	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.25
p.V894M	TCGA-G4-6626	COAD	TCGA	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.1389
p.V894M	DO9594	COAD	ICGC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.1389
p.S804P	TCGA-O2-A52Q	LUSC	TCGA	AASTS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.6752
p.S804P	DO219219	LUSC	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.6752
p.D888N	TCGA-QQ-A8VG	SARC	TCGA	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.3056
p.D888N	DO220260	SARC	ICGC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.3056
p.R890H	DO227709	COCA	ICGC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.25
p.D810Y	DO223142	ESCA	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.2222
p.A816V	DO233898	GACA	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.0556
p.G883D	DO233935	GACA	ICGC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation altering degron motif	0.7198
p.A812T	DO228258	MALY	ICGC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1667
p.A812T	SIDM01045	Endometrial Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1667
p.A812T	SIDM00217	Colorectal Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1667
p.A812T	SNU-1040	large intestine	COSMIC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1667
p.A812T	EN	endometrium	COSMIC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1667
p.D892N	DO46332	OV	ICGC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.1944
p.A816S	SIDM00217	Colorectal Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.0556
p.A816S	ACH-000999	Colon/Colorectal Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.0556
p.A816S	SNU-1040	large intestine	COSMIC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.0556
p.E871K	SIDM00901	Endometrial Carcinoma	GDSC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.0556
p.E871K	ACH-000940	Endometrial/Uterine Cancer	CCLE	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.0556
p.E871K	AN3-CA	endometrium	COSMIC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.0556
p.Q815H	SIDM01608	Endometrial Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.0833
p.Q815H	ACH-000990	Endometrial/Uterine Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.0833
p.G895D	SIDM01752	Pancreatic Carcinoma	GDSC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.1111
p.G801E	KYSE-220	oesophagus	COSMIC	AASTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.3056
p.P878R	SK-N-AS	autonomic ganglia	COSMIC	DSGITKS	DEG_SCF_TRCP1_1	881:887	Mutation rewiring degron network	0.25

Kaplan plot for KCNH1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNH1

UniProt ID: O95259

Entrez ID: 3756

Protein name: Potassium voltage-gated channel subfamily H member 1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Voltage-gated potassium channel subunit Kv10.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNH1 in