DegronMD

Uniprot ID: O95259

Source protein: Potassium voltage-gated channel subfamily H member 1

Source gene: KCNH1

Class: DEG_SCF_TRCP1_1

Location: 881:887

E3 ligase: BTRC

DEGRON score: 0.9929

ASA_SCORE: 78.1857

COIL: 0.8067

CONS_SCORE: 0.3207

DSS_SCORE: 0.4663

HELIX: 0.1459

FCONS_SCORE: 1.0044

RIG_SCORE: 0.7125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S887R	TCGA-15-1446	GBM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.7427
p.S887R	DO12490	GBM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.7427
p.A897T	TCGA-AX-A1C5	UCEC	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.0556
p.A897T	DO41422	UCEC	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.0556
p.S879L	TCGA-AZ-4315	COAD	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.2778
p.S879L	DO8842	COAD	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.2778
p.K876N	TCGA-DU-7013	LGG	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.3056
p.K876N	DO22217	LGG	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.3056
p.V894M	TCGA-G4-6626	COAD	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.1389
p.V894M	DO9594	COAD	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.1389
p.D888N	TCGA-QQ-A8VG	SARC	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.3056
p.D888N	DO220260	SARC	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.3056
p.R890H	DO227709	COCA	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.G883D	DO233935	GACA	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.7198
p.D892N	DO46332	OV	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.1944
p.E871K	SIDM00901	Endometrial Carcinoma	GDSC	DSGITKS	DEG_SCF_TRCP1_1	0.0556
p.E871K	ACH-000940	Endometrial/Uterine Cancer	CCLE	DSGITKS	DEG_SCF_TRCP1_1	0.0556
p.E871K	AN3-CA	endometrium	COSMIC	DSGITKS	DEG_SCF_TRCP1_1	0.0556
p.G895D	SIDM01752	Pancreatic Carcinoma	GDSC	DSGITKS	DEG_SCF_TRCP1_1	0.1111
p.P878R	SK-N-AS	autonomic_ganglia	COSMIC	DSGITKS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95259	Potassium voltage-gated channel subfamily H member 1	DEG_SCF_TRCP1_1	881:887	DSGITKS	BTRC	0.9929	More...
Q8NCM2	Potassium voltage-gated channel subfamily H member 5	DEG_SCF_TRCP1_1	865:871	DSGITKS	BTRC	0.9553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons