DegronMD - Q8NCM2(KCNH5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G879A	TCGA-17-Z027	LUAD	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.1111
p.R874C	TCGA-AP-A056	UCEC	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.25
p.R874C	TCGA-EB-A4IS	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.25
p.R874C	TCGA-EE-A183	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.25
p.R874C	TCGA-ER-A194	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.25
p.R874C	TCGA-IH-A3EA	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.25
p.R874C	DO37667	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.25
p.R874C	DO47281	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.25
p.R874C	DO37715	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.25
p.R874C	DO47646	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.25
p.R874C	DO43971	UCEC	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.25
p.P857T	TCGA-AP-A059	UCEC	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.1111
p.P857T	DO41361	UCEC	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.1111
p.A878T	TCGA-BF-A1PX	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.1389
p.A878T	DO51236	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.1389
p.S871R	TCGA-CG-4444	STAD	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation altering degron motif	0.7427
p.S871R	DO38300	STAD	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation altering degron motif	0.7427
p.T869K	TCGA-CN-5369	HNSC	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation altering degron motif	0.6195
p.T869K	DO16069	HNSC	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation altering degron motif	0.6195
p.L875F	TCGA-D3-A1Q3	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.2222
p.L875F	DO47509	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.2222
p.D862N	TCGA-ER-A42L	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.25
p.D862N	DO223910	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.25
p.S871N	TCGA-KB-A6F7	STAD	TCGA	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation altering degron motif	0.7069
p.S871N	DO50129	STAD	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation altering degron motif	0.7069
p.T861K	DO229045	LICA	ICGC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.2222
p.N856H	SIDM00150	Colorectal Carcinoma	GDSC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.0833
p.N856H	ACH-000969	Colon/Colorectal Cancer	CCLE	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.0833
p.N856H	KM12	large intestine	COSMIC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.0833
p.S863Y	SIDM01588	Endometrial Carcinoma	GDSC	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.2778
p.S863Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGITKS	DEG_SCF_TRCP1_1	865:871	Mutation rewiring degron network	0.2778

Kaplan plot for KCNH5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNH5

UniProt ID: Q8NCM2

Entrez ID: 27133

Protein name: Potassium voltage-gated channel subfamily H member 5 (Ether-a-go-go potassium channel 2) (hEAG2) (Voltage-gated potassium channel subunit Kv10.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNH5 in