DegronMD

Uniprot ID: Q8NCM2

Source protein: Potassium voltage-gated channel subfamily H member 5

Source gene: KCNH5

Class: DEG_SCF_TRCP1_1

Location: 865:871

E3 ligase: BTRC

DEGRON score: 0.9553

ASA_SCORE: 75.5

COIL: 0.8111

CONS_SCORE: 0.4105

DSS_SCORE: 0.5358

HELIX: 0.1109

FCONS_SCORE: 1.1586

RIG_SCORE: 0.6948

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G879A	TCGA-17-Z027	LUAD	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.1111
p.R874C	TCGA-AP-A056	UCEC	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.R874C	TCGA-EB-A4IS	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.R874C	TCGA-EE-A183	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.R874C	TCGA-ER-A194	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.R874C	TCGA-IH-A3EA	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.R874C	DO37667	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.R874C	DO47281	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.R874C	DO37715	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.R874C	DO47646	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.R874C	DO43971	UCEC	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.P857T	TCGA-AP-A059	UCEC	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.1111
p.P857T	DO41361	UCEC	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.1111
p.A878T	TCGA-BF-A1PX	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.1389
p.A878T	DO51236	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.1389
p.S871R	TCGA-CG-4444	STAD	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.7427
p.S871R	DO38300	STAD	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.7427
p.T869K	TCGA-CN-5369	HNSC	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.6195
p.T869K	DO16069	HNSC	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.6195
p.L875F	TCGA-D3-A1Q3	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.2222
p.L875F	DO47509	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.2222
p.D862N	TCGA-ER-A42L	SKCM	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.D862N	DO223910	SKCM	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.25
p.S871N	TCGA-KB-A6F7	STAD	TCGA	DSGITKS	DEG_SCF_TRCP1_1	0.7069
p.S871N	DO50129	STAD	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.7069
p.T861K	DO229045	LICA	ICGC	DSGITKS	DEG_SCF_TRCP1_1	0.2222
p.N856H	SIDM00150	Colorectal Carcinoma	GDSC	DSGITKS	DEG_SCF_TRCP1_1	0.0833
p.N856H	ACH-000969	Colon/Colorectal Cancer	CCLE	DSGITKS	DEG_SCF_TRCP1_1	0.0833
p.N856H	KM12	large_intestine	COSMIC	DSGITKS	DEG_SCF_TRCP1_1	0.0833
p.S863Y	SIDM01588	Endometrial Carcinoma	GDSC	DSGITKS	DEG_SCF_TRCP1_1	0.2778
p.S863Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGITKS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95259	Potassium voltage-gated channel subfamily H member 1	DEG_SCF_TRCP1_1	881:887	DSGITKS	BTRC	0.9929	More...
Q8NCM2	Potassium voltage-gated channel subfamily H member 5	DEG_SCF_TRCP1_1	865:871	DSGITKS	BTRC	0.9553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGITKS

Degron related mutations and impact score

Drug responses associated with KCNH5 mutations

All proteins holding degron of DSGITKS