DegronMD - Q9P2R6(RERE)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S609T	TCGA-12-0829	GBM	TCGA	AASTS	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.5833
p.S609T	DO11166	GBM	ICGC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.5833
p.A616T	TCGA-AM-5821	COAD	TCGA	AASTS	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7139
p.A616T	DO8240	COAD	ICGC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7139
p.A770V	TCGA-CN-5369	HNSC	TCGA	LPTPGPT	DEG_SCF_FBW7_1	761:767	Mutation rewiring degron network	0.25
p.A770V	DO16069	HNSC	ICGC	LPTPGPT	DEG_SCF_FBW7_1	761:767	Mutation rewiring degron network	0.25
p.S609G	TCGA-D1-A167	UCEC	TCGA	AASTS	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.5833
p.S609G	DO40978	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.5833
p.G746V	TCGA-D3-A2JG	SKCM	TCGA	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation rewiring degron network	0.3056
p.G746V	DO47613	SKCM	ICGC	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation rewiring degron network	0.3056
p.A740S	TCGA-GN-A262	SKCM	TCGA	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation rewiring degron network	0.1389
p.A740S	DO37515	SKCM	ICGC	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation rewiring degron network	0.1389
p.G757E	TCGA-GN-A4U3	SKCM	TCGA	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation rewiring degron network	0.1944
p.G757E	TCGA-GN-A4U3	SKCM	TCGA	LPTPGPT	DEG_SCF_FBW7_1	761:767	Mutation rewiring degron network	0.2222
p.G757E	DO219484	SKCM	ICGC	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation rewiring degron network	0.1944
p.G757E	DO219484	SKCM	ICGC	LPTPGPT	DEG_SCF_FBW7_1	761:767	Mutation rewiring degron network	0.2222
p.S621G	TCGA-HE-A5NI	KIRP	TCGA	AASTS	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.75
p.S621G	DO49767	KIRP	ICGC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.75
p.P766L	TCGA-IB-AAUU	PAAD	TCGA	LPTPGPT	DEG_SCF_FBW7_1	761:767	Mutation altering degron motif	0.6471
p.P766L	DO51712	PAAD	ICGC	LPTPGPT	DEG_SCF_FBW7_1	761:767	Mutation altering degron motif	0.6471
p.R611W	DO230311	COCA	ICGC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1944
p.N622D	DO231934	LICA	ICGC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2778
p.T628K	DO229029	LICA	ICGC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1111
p.A1066D	DO229046	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	1053:1057	Mutation rewiring degron network	0.0833
p.P751S	DO222875	MELA	ICGC	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation altering degron motif	0.5641
p.A772T	DO229253	THCA	ICGC	LPTPGPT	DEG_SCF_FBW7_1	761:767	Mutation rewiring degron network	0.1944
p.S615N	SIDM00447	B-Lymphoblastic Leukemia	GDSC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.75
p.S615N	ACH-000960	Leukemia	CCLE	AASTS	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.75
p.S615N	REH	haematopoietic and lymphoid tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.75
p.Q1067E	SIDM00040	Gastric Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	1053:1057	Mutation rewiring degron network	0.0556
p.R607H	SIDM00618	Hepatocellular Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.0833
p.R607H	ACH-000620	Liver Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.0833
p.R607H	JHH-1	liver	COSMIC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.0833
p.T1048S	ACH-000328	Brain Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	1053:1057	Mutation rewiring degron network	0.1944
p.G610C	ACH-000385	Kidney Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1667
p.P774S	ACH-000894	Lung Cancer	CCLE	LPTPGPT	DEG_SCF_FBW7_1	761:767	Mutation rewiring degron network	0.1389
p.T1057I	ACH-000947	Ovarian Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	1053:1057	Mutation altering degron motif	0.7078
p.P744L	ACH-000985	Colon/Colorectal Cancer	CCLE	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation rewiring degron network	0.25
p.Q737H	ACH-000997	Colon/Colorectal Cancer	CCLE	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation rewiring degron network	0.0556
p.Q737H	ACH-001061	Colon/Colorectal Cancer	CCLE	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation rewiring degron network	0.0556
p.G757A	ACH-001795	Liposarcoma	CCLE	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation rewiring degron network	0.1944
p.G757A	ACH-001795	Liposarcoma	CCLE	LPTPGPT	DEG_SCF_FBW7_1	761:767	Mutation rewiring degron network	0.2222
p.E626V	HCC1569	breast	COSMIC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1667
p.R625L	CHP-212	autonomic ganglia	COSMIC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation substituting flanking lysine	0.3056
p.R630Q	LXF-289	lung	COSMIC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation substituting flanking lysine	0.1667
p.R763Q	NCI-H1155	lung	COSMIC	LPTPGPT	DEG_SCF_FBW7_1	761:767	Mutation altering degron motif	0.7329
p.R748Q	JM1	haematopoietic and lymphoid tissue	COSMIC	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation altering degron motif	0.7329
p.P743S	SNU-1040	large intestine	COSMIC	VTPAPS	DEG_SCF_FBW7_1	747:752	Mutation rewiring degron network	0.2222
p.R1049Q	NCI-H1155	lung	COSMIC	PSTST	DEG_SPOP_SBC_1	1053:1057	Mutation rewiring degron network	0.2222
p.R625Q	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation substituting flanking lysine	0.3056
p.R618C	HCT-116	large intestine	COSMIC	AASTS	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.8301

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RERE

UniProt ID: Q9P2R6

Entrez ID: 473

Protein name: Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RERE in