DegronMD

Uniprot ID: Q9P2R6

Source protein: Arginine-glutamic acid dipeptide repeats protein

Source gene: RERE

Class: DEG_SCF_FBW7_1

Location: 747:752

E3 ligase: FBXW7

DEGRON score: 0.9571

ASA_SCORE: 88

COIL: 0.9615

CONS_SCORE: 0.4828

DSS_SCORE: 0.8342

HELIX: 0.0145

FCONS_SCORE: 1.2345

RIG_SCORE: 0.5339

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G746V	TCGA-D3-A2JG	SKCM	TCGA	VTPAPS	DEG_SCF_FBW7_1	0.3056
p.G746V	DO47613	SKCM	ICGC	VTPAPS	DEG_SCF_FBW7_1	0.3056
p.A740S	TCGA-GN-A262	SKCM	TCGA	VTPAPS	DEG_SCF_FBW7_1	0.1389
p.A740S	DO37515	SKCM	ICGC	VTPAPS	DEG_SCF_FBW7_1	0.1389
p.G757E	TCGA-GN-A4U3	SKCM	TCGA	VTPAPS	DEG_SCF_FBW7_1	0.1944
p.G757E	DO219484	SKCM	ICGC	VTPAPS	DEG_SCF_FBW7_1	0.1944
p.P751S	DO222875	MELA	ICGC	VTPAPS	DEG_SCF_FBW7_1	0.5641
p.P744L	ACH-000985	Colon/Colorectal Cancer	CCLE	VTPAPS	DEG_SCF_FBW7_1	0.25
p.Q737H	ACH-000997	Colon/Colorectal Cancer	CCLE	VTPAPS	DEG_SCF_FBW7_1	0.0556
p.Q737H	ACH-001061	Colon/Colorectal Cancer	CCLE	VTPAPS	DEG_SCF_FBW7_1	0.0556
p.G757A	ACH-001795	Liposarcoma	CCLE	VTPAPS	DEG_SCF_FBW7_1	0.1944
p.R748Q	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	VTPAPS	DEG_SCF_FBW7_1	0.7329
p.P743S	SNU-1040	large_intestine	COSMIC	VTPAPS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14594	Neurocan core protein	DEG_SCF_FBW7_1	833:838	VTPAPS	FBXW7	0.9882	More...
Q9P2R6	Arginine-glutamic acid dipeptide repeats protein	DEG_SCF_FBW7_1	747:752	VTPAPS	FBXW7	0.9571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons