DegronMD

Uniprot ID: O14594

Source protein: Neurocan core protein

Source gene: NCAN

Class: DEG_SCF_FBW7_1

Location: 833:838

E3 ligase: FBXW7

DEGRON score: 0.9882

ASA_SCORE: 68.6333

COIL: 0.8245

CONS_SCORE: 0.4782

DSS_SCORE: 0.6363

HELIX: 0.028

FCONS_SCORE: 0.9418

RIG_SCORE: 0.6772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P835S	TCGA-AB-2833	LAML	TCGA	VTPAPS	DEG_SCF_FBW7_1	0.6752
p.T825A	TCGA-BR-4363	STAD	TCGA	VTPAPS	DEG_SCF_FBW7_1	0.1111
p.T834M	TCGA-BR-6566	STAD	TCGA	VTPAPS	DEG_SCF_FBW7_1	0.7423
p.S831Y	TCGA-DK-A6AW	BLCA	TCGA	VTPAPS	DEG_SCF_FBW7_1	0.2778
p.P828L	TCGA-EE-A2MR	SKCM	TCGA	VTPAPS	DEG_SCF_FBW7_1	0.1944
p.P828S	TCGA-GF-A6C8	SKCM	TCGA	VTPAPS	DEG_SCF_FBW7_1	0.1944
p.P828H	SIDM00789	Colorectal Carcinoma	GDSC	VTPAPS	DEG_SCF_FBW7_1	0.1944
p.P828H	ACH-000997	Colon/Colorectal Cancer	CCLE	VTPAPS	DEG_SCF_FBW7_1	0.1944
p.P828H	ACH-001061	Colon/Colorectal Cancer	CCLE	VTPAPS	DEG_SCF_FBW7_1	0.1944
p.P828H	HCT-15	large_intestine	COSMIC	VTPAPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14594	Neurocan core protein	DEG_SCF_FBW7_1	833:838	VTPAPS	FBXW7	0.9882	More...
Q9P2R6	Arginine-glutamic acid dipeptide repeats protein	DEG_SCF_FBW7_1	747:752	VTPAPS	FBXW7	0.9571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons