DegronMD - O14594(NCAN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q849K	TCGA-05-4396	LUAD	TCGA	AESTT	DEG_SPOP_SBC_1	854:858	Mutation rewiring degron network	0.1944
p.V863L	TCGA-17-Z031	LUAD	TCGA	IVTPLTT	DEG_SCF_FBW7_1	869:875	Mutation rewiring degron network	0.1667
p.V863L	TCGA-17-Z031	LUAD	TCGA	AESTT	DEG_SPOP_SBC_1	854:858	Mutation rewiring degron network	0.1944
p.V863L	TCGA-60-2715	LUSC	TCGA	IVTPLTT	DEG_SCF_FBW7_1	869:875	Mutation rewiring degron network	0.1667
p.V863L	TCGA-60-2715	LUSC	TCGA	AESTT	DEG_SPOP_SBC_1	854:858	Mutation rewiring degron network	0.1944
p.T871M	TCGA-25-1320	OV	TCGA	IVTPLTT	DEG_SCF_FBW7_1	869:875	Mutation altering degron motif	0.7423
p.P802S	TCGA-25-2398	OV	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	808:815	Mutation rewiring degron network	0.1667
p.G939V	TCGA-49-AAR9	LUAD	TCGA	SVSSGE	DEG_Kelch_Keap1_1	943:948	Mutation rewiring degron network	0.2222
p.G947A	TCGA-51-4079	LUSC	TCGA	SVSSGE	DEG_Kelch_Keap1_1	943:948	Mutation altering degron motif	0.754
p.Q862L	TCGA-56-8082	LUSC	TCGA	IVTPLTT	DEG_SCF_FBW7_1	869:875	Mutation rewiring degron network	0.1389
p.Q862L	TCGA-56-8082	LUSC	TCGA	AESTT	DEG_SPOP_SBC_1	854:858	Mutation rewiring degron network	0.2222
p.P816T	TCGA-A5-A0G1	UCEC	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	808:815	Mutation rewiring degron network	0.3056
p.P835S	TCGA-AB-2833	LAML	TCGA	VTPAPS	DEG_SCF_FBW7_1	833:838	Mutation altering degron motif	0.6752
p.D821Y	TCGA-AX-A2HC	UCEC	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	808:815	Mutation rewiring degron network	0.1667
p.V884L	TCGA-B6-A0RS	BRCA	TCGA	IVTPLTT	DEG_SCF_FBW7_1	869:875	Mutation rewiring degron network	0.0833
p.T825A	TCGA-BR-4363	STAD	TCGA	VTPAPS	DEG_SCF_FBW7_1	833:838	Mutation rewiring degron network	0.1111
p.T825A	TCGA-BR-4363	STAD	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	808:815	Mutation rewiring degron network	0.0556
p.T834M	TCGA-BR-6566	STAD	TCGA	VTPAPS	DEG_SCF_FBW7_1	833:838	Mutation altering degron motif	0.7423
p.T874M	TCGA-BR-6566	STAD	TCGA	IVTPLTT	DEG_SCF_FBW7_1	869:875	Mutation altering degron motif	0.6312
p.D821N	TCGA-CK-4951	COAD	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	808:815	Mutation rewiring degron network	0.1667
p.V804F	TCGA-D1-A103	UCEC	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	808:815	Mutation rewiring degron network	0.2222
p.P885S	TCGA-D3-A2JL	SKCM	TCGA	IVTPLTT	DEG_SCF_FBW7_1	869:875	Mutation rewiring degron network	0.0556
p.S831Y	TCGA-DK-A6AW	BLCA	TCGA	VTPAPS	DEG_SCF_FBW7_1	833:838	Mutation rewiring degron network	0.2778
p.N813H	TCGA-E6-A1LX	UCEC	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	808:815	Mutation altering degron motif	0.6312
p.P828L	TCGA-EE-A2MR	SKCM	TCGA	VTPAPS	DEG_SCF_FBW7_1	833:838	Mutation rewiring degron network	0.1944
p.L814V	TCGA-EO-A3B0	UCEC	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	808:815	Mutation altering degron motif	0.5654
p.E815K	TCGA-ER-A19Q	SKCM	TCGA	PKVTPNLE	DEG_SCF_FBW7_2	808:815	Mutation altering degron motif	0.7022
p.D866N	TCGA-FD-A3NA	BLCA	TCGA	IVTPLTT	DEG_SCF_FBW7_1	869:875	Mutation rewiring degron network	0.25
p.D866N	TCGA-FD-A3NA	BLCA	TCGA	AESTT	DEG_SPOP_SBC_1	854:858	Mutation rewiring degron network	0.1111
p.P828S	TCGA-GF-A6C8	SKCM	TCGA	VTPAPS	DEG_SCF_FBW7_1	833:838	Mutation rewiring degron network	0.1944
p.A936G	SIDM00955	Melanoma	GDSC	SVSSGE	DEG_Kelch_Keap1_1	943:948	Mutation rewiring degron network	0.1389
p.P828H	SIDM00789	Colorectal Carcinoma	GDSC	VTPAPS	DEG_SCF_FBW7_1	833:838	Mutation rewiring degron network	0.1944
p.P828H	ACH-000997	Colon/Colorectal Cancer	CCLE	VTPAPS	DEG_SCF_FBW7_1	833:838	Mutation rewiring degron network	0.1944
p.P828H	ACH-001061	Colon/Colorectal Cancer	CCLE	VTPAPS	DEG_SCF_FBW7_1	833:838	Mutation rewiring degron network	0.1944
p.P828H	HCT-15	large intestine	COSMIC	VTPAPS	DEG_SCF_FBW7_1	833:838	Mutation rewiring degron network	0.1944
p.D821G	SIDM00581	Glioblastoma	GDSC	PKVTPNLE	DEG_SCF_FBW7_2	808:815	Mutation rewiring degron network	0.1667
p.D821G	ACH-000738	Brain Cancer	CCLE	PKVTPNLE	DEG_SCF_FBW7_2	808:815	Mutation rewiring degron network	0.1667
p.D821G	GB-1	central nervous system	COSMIC	PKVTPNLE	DEG_SCF_FBW7_2	808:815	Mutation rewiring degron network	0.1667
p.T875S	SIDM01121	Small Cell Lung Carcinoma	GDSC	IVTPLTT	DEG_SCF_FBW7_1	869:875	Mutation altering degron motif	0.6005
p.T875S	SIDM00793	Burkitt's Lymphoma	GDSC	IVTPLTT	DEG_SCF_FBW7_1	869:875	Mutation altering degron motif	0.6005
p.Q849H	SIDM01770	Gastric Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	854:858	Mutation rewiring degron network	0.1944
p.Q849H	ACH-000908	Gastric Cancer	CCLE	AESTT	DEG_SPOP_SBC_1	854:858	Mutation rewiring degron network	0.1944
p.E855K	SIDM01368	Gastric Carcinoma	GDSC	AESTT	DEG_SPOP_SBC_1	854:858	Mutation altering degron motif	0.591

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCAN

UniProt ID: O14594

Entrez ID: 1463

Protein name: Neurocan core protein (Chondroitin sulfate proteoglycan 3)

External links: UniprotKB HGNC RefSeq COSMIC

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