DegronMD

Uniprot ID: O14594

Source protein: Neurocan core protein

Source gene: NCAN

Class: DEG_Kelch_Keap1_1

Location: 943:948

E3 ligase: KEAP1

DEGRON score: 0.9946

ASA_SCORE: 74.1833

COIL: 0.8332

CONS_SCORE: 0.5944

DSS_SCORE: 0.5959

HELIX: 0.0605

FCONS_SCORE: 1.2724

RIG_SCORE: 0.5824

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G939V	TCGA-49-AAR9	LUAD	TCGA	SVSSGE	DEG_Kelch_Keap1_1	0.2222
p.G947A	TCGA-51-4079	LUSC	TCGA	SVSSGE	DEG_Kelch_Keap1_1	0.754
p.A936G	SIDM00955	Melanoma	GDSC	SVSSGE	DEG_Kelch_Keap1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons